Laminin, alpha 1

LAMA1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2JD4
Identifiers
Aliases	LAMA1 , LAMA, S-LAM-alpha, PTBHS, Laminin, alpha 1, laminin subunit alpha 1
External IDs	OMIM: 150320 MGI: 99892 HomoloGene: 21146 GeneCards: LAMA1
Gene location (Human) Chr. Chromosome 18 (human) [1] Band 18p11.31 Start 6,941,742 bp [1] End 7,117,797 bp [1]
Gene location (Mouse) Chr. Chromosome 17 (mouse) [2] Band 17 E1.1|17 38.8 cM Start 68,004,254 bp [2] End 68,129,642 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Stromal cell of endometrium ganglionic eminence rectum left lobe of thyroid gland right lobe of thyroid gland body of pancreas kidney caudate nucleus jejunal mucosa putamen Top expressed in Bowman's capsule ovary cumulus cells inner renal medulla yolk sac cortical collecting duct primitive streak somite molar medullary collecting duct More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signaling receptor binding extracellular matrix structural constituent GO:0001948, GO:0016582 protein binding protein C-terminus binding glycosphingolipid binding Cellular component GO:0005578 extracellular matrix extracellular region basement membrane laminin-1 complex laminin-3 complex extracellular space membrane cell-cell junction laminin complex collagen-containing extracellular matrix Biological process cell surface receptor signaling pathway regulation of cell adhesion cell adhesion extracellular matrix organization regulation of cell migration regulation of embryonic development morphogenesis of an epithelial sheet protein phosphorylation tissue development neuron projection development establishment of epithelial cell apical/basal polarity retina development in camera-type eye epithelial tube branching involved in lung morphogenesis branching involved in salivary gland morphogenesis retinal blood vessel morphogenesis axon guidance animal organ morphogenesis camera-type eye development blood vessel morphogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 284217 16772 Ensembl ENSG00000101680 ENSMUSG00000032796 UniProt P25391 P19137 RefSeq (mRNA) NM_005559 NM_008480 RefSeq (protein) NP_005550 NP_032506 Location (UCSC) Chr 18: 6.94 – 7.12 Mb Chr 17: 68 – 68.13 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Laminin subunit alpha-1 is a protein that in humans is encoded by the LAMA1 gene. ^{[5] [6]}

Interactions

Laminin, alpha 1 has been shown to interact with FBLN2. ^{[7] [8]}

Role in pathology

Mutations of the LAMA1 gene cause the Poretti–Boltshauser syndrome.

References

1. GRCh38: Ensembl release 89: ENSG00000101680 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032796 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagayoshi T, Mattei MG, Passage E, Knowlton R, Chu ML, Uitto J (January 1990). "Human laminin A chain (LAMA) gene: chromosomal mapping to locus 18p11.3". Genomics. 5 (4): 932–5. doi:10.1016/0888-7543(89)90136-5. PMID   2591971.
6. "Entrez Gene: LAMA1 laminin, alpha 1".
7. Utani, A; Nomizu M; Yamada Y (January 1997). "Fibulin-2 binds to the short arms of laminin-5 and laminin-1 via conserved amino acid sequences". J. Biol. Chem. 272 (5): 2814–20. doi: 10.1074/jbc.272.5.2814 . ISSN   0021-9258. PMID   9006922. S2CID   24800195.
8. Talts, J F; Sasaki T; Miosge N; Göhring W; Mann K; Mayne R; Timpl R (November 2000). "Structural and functional analysis of the recombinant G domain of the laminin alpha4 chain and its proteolytic processing in tissues". J. Biol. Chem. 275 (45): 35192–9. doi: 10.1074/jbc.M003261200 . ISSN   0021-9258. PMID   10934193. S2CID   36521395.

Further reading

• Haaparanta T, Uitto J, Ruoslahti E, Engvall E (1991). "Molecular cloning of the cDNA encoding human laminin A chain". Matrix. 11 (3): 151–60. doi:10.1016/s0934-8832(11)80153-8. PMID   1714537.
• Nissinen M, Vuolteenaho R, Boot-Handford R, et al. (1991). "Primary structure of the human laminin A chain. Limited expression in human tissues". Biochem. J. 276 ( Pt 2) (Pt 2): 369–79. doi:10.1042/bj2760369. PMC   1151101 . PMID   2049067.
• Taraboletti G, Rao CN, Krutzsch HC, et al. (1990). "Sulfatide-binding domain of the laminin A chain". J. Biol. Chem. 265 (21): 12253–8. doi: 10.1016/S0021-9258(19)38338-3 . PMID   2373692.
• Olsen D, Nagayoshi T, Fazio M, et al. (1989). "Human laminin: cloning and sequence analysis of cDNAs encoding A, B1 and B2 chains, and expression of the corresponding genes in human skin and cultured cells". Lab. Invest. 60 (6): 772–82. PMID   2733383.
• Leivo I, Engvall E (1986). "C3d fragment of complement interacts with laminin and binds to basement membranes of glomerulus and trophoblast". J. Cell Biol. 103 (3): 1091–100. doi:10.1083/jcb.103.3.1091. PMC   2114300 . PMID   3488995.
• Wewer UM, Gerecke DR, Durkin ME, et al. (1995). "Human beta 2 chain of laminin (formerly S chain): cDNA cloning, chromosomal localization, and expression in carcinomas". Genomics. 24 (2): 243–52. doi:10.1006/geno.1994.1612. PMID   7698745.
• Yamada H, Shimizu T, Tanaka T, et al. (1994). "Dystroglycan is a binding protein of laminin and merosin in peripheral nerve". FEBS Lett. 352 (1): 49–53. doi:10.1016/0014-5793(94)00917-1. PMID   7925941. S2CID   17529055.
• Moser TL, Enghild JJ, Pizzo SV, Stack MS (1993). "The extracellular matrix proteins laminin and fibronectin contain binding domains for human plasminogen and tissue plasminogen activator". J. Biol. Chem. 268 (25): 18917–23. doi: 10.1016/S0021-9258(17)46714-7 . PMID   8360181.
• Yurchenco PD, Sung U, Ward MD, et al. (1993). "Recombinant laminin G domain mediates myoblast adhesion and heparin binding". J. Biol. Chem. 268 (11): 8356–65. doi: 10.1016/S0021-9258(18)53103-3 . PMID   8463343.
• Ancsin JB, Kisilevsky R (1997). "Characterization of high affinity binding between laminin and the acute-phase protein, serum amyloid A". J. Biol. Chem. 272 (1): 406–13. doi: 10.1074/jbc.272.1.406 . PMID   8995276. S2CID   37912337.
• Zahedi K (1997). "Characterization of the binding of serum amyloid P to laminin". J. Biol. Chem. 272 (4): 2143–8. doi:10.1074/S0021-9258(19)78482-8. PMID   8999915.
• Utani A, Nomizu M, Yamada Y (1997). "Fibulin-2 binds to the short arms of laminin-5 and laminin-1 via conserved amino acid sequences". J. Biol. Chem. 272 (5): 2814–20. doi: 10.1074/jbc.272.5.2814 . PMID   9006922. S2CID   24800195.
• Cáceres J, Brandan E (1997). "Interaction between Alzheimer's disease beta A4 precursor protein (APP) and the extracellular matrix: evidence for the participation of heparan sulfate proteoglycans". J. Cell. Biochem. 65 (2): 145–58. doi:10.1002/(SICI)1097-4644(199705)65:2<145::AID-JCB2>3.0.CO;2-U. PMID   9136074. S2CID   43911847.
• Chen M, Marinkovich MP, Veis A, et al. (1997). "Interactions of the amino-terminal noncollagenous (NC1) domain of type VII collagen with extracellular matrix components. A potential role in epidermal-dermal adherence in human skin". J. Biol. Chem. 272 (23): 14516–22. doi: 10.1074/jbc.272.23.14516 . PMID   9169408. S2CID   7310763.
• Schuger L, Skubitz AP, Zhang J, et al. (1997). "Laminin α1 Chain Synthesis in the Mouse Developing Lung: Requirement for Epithelial–Mesenchymal Contact and Possible Role in Bronchial Smooth muscle Development". J. Cell Biol. 139 (2): 553–62. doi:10.1083/jcb.139.2.553. PMC   2139794 . PMID   9334356.
• Mrowiec T, Melchar C, Górski A (1998). "HIV-protein-mediated alterations in T cell interactions with the extracellular matrix proteins and endothelium". Arch. Immunol. Ther. Exp. (Warsz.). 45 (2–3): 255–9. PMID   9597096.
• O'Grady P, Thai TC, Saito H (1998). "The Laminin–Nidogen Complex is a Ligand for a Specific Splice Isoform of the Transmembrane Protein Tyrosine Phosphatase LAR". J. Cell Biol. 141 (7): 1675–84. doi:10.1083/jcb.141.7.1675. PMC   2133008 . PMID   9647658.
• Ettner N, Göhring W, Sasaki T, et al. (1998). "The N-terminal globular domain of the laminin alpha1 chain binds to alpha1beta1 and alpha2beta1 integrins and to the heparan sulfate-containing domains of perlecan". FEBS Lett. 430 (3): 217–21. doi: 10.1016/S0014-5793(98)00601-2 . PMID   9688542. S2CID   84569969.
• Ludwig HC, Rausch S, Schallock K, Markakis E (1999). "Expression of CD 73 (ecto-5'-nucleotidase) in 165 glioblastomas by immunohistochemistry and electronmicroscopic histochemistry". Anticancer Res. 19 (3A): 1747–52. PMID   10470109.