Collagen, type XIV, alpha 1

COL14A1
Identifiers
Aliases	COL14A1 , UND, Collagen, type XIV, alpha 1, collagen type XIV alpha 1, collagen type XIV alpha 1 chain
External IDs	OMIM: 120324 MGI: 1341272 HomoloGene: 18741 GeneCards: COL14A1
Gene location (Human)
Chr.	Chromosome 8 (human)
End	120,373,573 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	55,384,199 bp
RNA expression pattern
	Top expressed in
	right coronary artery; ; popliteal artery; ; ascending aorta; ; gallbladder; ; left coronary artery; ; saphenous vein; ; Achilles tendon; ; vena cava; ; superficial temporal artery; ; vulva;
	Top expressed in
	vas deferens; ; conjunctival fornix; ; dermis; ; semi-lunar valve; ; aortic valve; ; ascending aorta; ; left lung lobe; ; atrioventricular valve; ; skin of abdomen; ; sciatic nerve;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein-macromolecule adaptor activity ; extracellular matrix structural constituent ; collagen binding ; RNA binding ; extracellular matrix structural constituent conferring tensile strength ;
Cellular component	extracellular matrix ; collagen ; endoplasmic reticulum lumen ; extracellular exosome ; collagen type XIV trimer ; extracellular space ; extracellular region ; collagen-containing extracellular matrix ;
Biological process	cell adhesion ; collagen fibril organization ; extracellular matrix organization ; cell-cell adhesion ; growth plate cartilage chondrocyte morphogenesis ;
	Sources:Amigo / QuickGO
Orthologs
	7373
	12818
	ENSG00000187955
	ENSMUSG00000022371
	Q05707
	Q80X19
	NM_021110 ; NM_001384947
	NM_181277 ; NM_001368422
	NP_066933
	NP_851794 ; NP_001355351
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated November 22, 2023

Collagen alpha-1(XIV) chain is a protein that in humans is encoded by the COL14A1 gene.^[5]^[6]^[7] It likely plays a role in collagen binding and cell-cell adhesion.^[8]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000187955 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022371 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Just M, Herbst H, Hummel M, Durkop H, Tripier D, Stein H, Schuppan D (Oct 1991). "Undulin is a novel member of the fibronectin-tenascin family of extracellular matrix glycoproteins". J Biol Chem. 266 (26): 17326–32. doi: 10.1016/S0021-9258(19)47377-8 . PMID 1716629.
↑ Bauer M, Dieterich W, Ehnis T, Schuppan D (Jan 1998). "Complete primary structure of human collagen type XIV (undulin)". Biochim Biophys Acta. 1354 (3): 183–8. doi:10.1016/S0167-4781(97)00131-0. PMID 9427527.
↑ "Entrez Gene: COL14A1 collagen, type XIV, alpha 1 (undulin)".
↑ "COL14A1 - Collagen alpha-1(XIV) chain precursor - Homo sapiens (Human) - COL14A1 gene & protein".

Schuppan D, Cantaluppi MC, Becker J, et al. (1990). "Undulin, an extracellular matrix glycoprotein associated with collagen fibrils". J. Biol. Chem. 265 (15): 8823–32. doi: 10.1016/S0021-9258(19)38962-8 . PMID 2187872.
Schnittger S, Herbst H, Schuppan D, et al. (1995). "Localization of the undulin gene (UND) to human chromosome band 8q23". Cytogenet. Cell Genet. 68 (3–4): 233–4. doi:10.1159/000133920. PMID 7842743.
Casini A, Ceni E, Salzano R, et al. (1994). "Regulation of undulin synthesis and gene expression in human fat-storing cells by acetaldehyde and transforming growth factor-beta 1: comparison with fibronectin". Biochem. Biophys. Res. Commun. 199 (2): 1019–26. doi:10.1006/bbrc.1994.1331. PMID 8135774.
Tono-Oka S, Tanase S, Miike T, Tanaka H (1996). "Transient expression of collagen type XIV during muscle development and its reappearance after denervation and degeneration". J. Histochem. Cytochem. 44 (8): 907–18. doi: 10.1177/44.8.8756762 . PMID 8756762.
Ehnis T, Dieterich W, Bauer M, et al. (1997). "A chondroitin/dermatan sulfate form of CD44 is a receptor for collagen XIV (undulin)". Exp. Cell Res. 229 (2): 388–97. doi:10.1006/excr.1996.0384. PMID 8986622.
Göpel C, Schultka R, Schuppan D (1997). "[Age-dependent distribution of collagen and glycoproteins in the blood vessels of the human uterine tube]". Ann. Anat. 179 (1): 83–8. doi:10.1016/S0940-9602(97)80144-6. PMID 9092299.
Ehnis T, Dieterich W, Bauer M, et al. (1997). "Localization of a binding site for the proteoglycan decorin on collagen XIV (undulin)". J. Biol. Chem. 272 (33): 20414–9. doi: 10.1074/jbc.272.33.20414 . PMID 9252349.
Imhof M, Trueb B (1999). "Comparative cytogenetic mapping of COL14A1, the gene for human and mouse collagen XIV". Cytogenet. Cell Genet. 84 (3–4): 217–9. doi:10.1159/000015262. PMID 10393435. S2CID 24286993.
Fukushima M, Hirano S, Tanaka H (2000). "Dorsoventral differential distribution of collagen type XIV around the spinal cord is regulated by the ectoderm". Dev. Growth Differ. 41 (6): 751–8. doi: 10.1046/j.1440-169x.1999.00472.x . PMID 10646805. S2CID 32320869.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Gerecke DR, Meng X, Liu B, Birk DE (2004). "Complete primary structure and genomic organization of the mouse Col14a1 gene". Matrix Biol. 22 (7): 595–601. doi:10.1016/j.matbio.2003.11.005. PMID 15065570.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Thierry L, Geiser AS, Hansen A, et al. (2005). "Collagen types XII and XIV are present in basement membrane zones during human embryonic development". J. Mol. Histol. 35 (8–9): 803–10. doi:10.1007/s10735-004-1132-y. PMID 15609093. S2CID 30409158.
Ruehl M, Erben U, Schuppan D, et al. (2006). "The elongated first fibronectin type III domain of collagen XIV is an inducer of quiescence and differentiation in fibroblasts and preadipocytes". J. Biol. Chem. 280 (46): 38537–43. doi: 10.1074/jbc.M502210200 . PMID 16129687.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Nusbaum C, Mikkelsen TS, Zody MC, et al. (2006). "DNA sequence and analysis of human chromosome 8". Nature. 439 (7074): 331–5. Bibcode:2006Natur.439..331N. doi: 10.1038/nature04406 . PMID 16421571.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000187955 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022371 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1716629-5] Just M, Herbst H, Hummel M, Durkop H, Tripier D, Stein H, Schuppan D (Oct 1991). "Undulin is a novel member of the fibronectin-tenascin family of extracellular matrix glycoproteins". J Biol Chem. 266 (26): 17326–32. doi: 10.1016/S0021-9258(19)47377-8 . PMID 1716629.

[pmid9427527-6] Bauer M, Dieterich W, Ehnis T, Schuppan D (Jan 1998). "Complete primary structure of human collagen type XIV (undulin)". Biochim Biophys Acta. 1354 (3): 183–8. doi:10.1016/S0167-4781(97)00131-0. PMID 9427527.

[entrez-7] "Entrez Gene: COL14A1 collagen, type XIV, alpha 1 (undulin)".

[8] "COL14A1 - Collagen alpha-1(XIV) chain precursor - Homo sapiens (Human) - COL14A1 gene & protein".

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Collagen, type XIV, alpha 1

Related Research Articles

References

Further reading