Type II collagen

Last updated
collagen, type II, alpha 1 (primary osteoarthritis, spondyloepiphyseal dysplasia, congenital)
Identifiers
Symbol COL2A1
Alt. symbolsSEDC
NCBI gene 1280
HGNC 2200
OMIM 120140
RefSeq NM_001844
UniProt P02458
Other data
Locus Chr. 12 q13.11-q13.2
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Structures Swiss-model
Domains InterPro

Type II collagen is the basis for hyaline cartilage, including the articular cartilages at joint surfaces. It is formed by homotrimers of collagen, type II, alpha 1 chains.

Contents

It makes up 50% of all protein in cartilage and 85–90% of collagen of articular cartilage.

Type II collagen is organised into fibrils. This fibrillar network of collagen allows the cartilage to entrap the proteoglycan aggregate, as well as providing tensile strength to the tissue. Oral administration of native type II collagen induces oral tolerance to pathological immune responses [1] and the administration of type II collagen tablets together with paracetamol might be more effective at reducing symptoms of osteoarthritis than paracetamol by itself. [2] [3]

See also

References

  1. ↑ Park KS, Park MJ, Cho ML, Kwok SK, Ju JH, Ko HJ, Park SH, Kim HY (2009). "Type II collagen oral tolerance; mechanism and role in collagen-induced arthritis and rheumatoid arthritis". Modern Rheumatology. 19 (6): 581–9. doi:10.1007/s10165-009-0210-0. PMID   19697097. S2CID   207061498.
  2. ↑ Park KS, Park MJ, Cho ML, Kwok SK, Ju JH, Ko HJ, Park SH, Kim HY (2009). "Type II collagen oral tolerance; mechanism and role in collagen-induced arthritis and rheumatoid arthritis". Modern Rheumatology. 19 (6): 581–9. doi:10.1007/s10165-009-0210-0. PMID   19697097. S2CID   207061498.
  3. ↑ Bakilan F, Armagan O, Ozgen M, Tascioglu F, Bolluk O, Alatas O (June 2016). "Effects of Native Type II Collagen Treatment on Knee Osteoarthritis: A Randomized Controlled Trial". The Eurasian Journal of Medicine. 48 (2): 95–101. doi:10.5152/eurasianjmed.2015.15030. PMC   4970562 . PMID   27551171.
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