| Name | Developer | Publisher | Genre(s) | Operating system(s) | Date released |
|---|
| Sacred | Ascaron | Encore, Koch Media, Red Ant Enterprises | Action RPG | Microsoft Windows, Linux | March 19, 2004 |
| The Sacred Hero | SiMPLiSTiC | SiMPLiSTiC | RPG | Microsoft Windows, Linux | TBA |
| Saints Row 2 | Volition, CD Projekt (Windows) | THQ | Action-adventure, open world | Microsoft Windows | January 5, 2009 |
| Saints Row: The Third | Volition | THQ | Action-adventure, open world | Microsoft Windows | November 15, 2011 |
| Saints Row IV | Volition | Deep Silver, Spike Chunsoft | Action-adventure, open world | Microsoft Windows | August 20, 2013 |
| Sands of Salzaar | Han-Squirrel Studio | XD | Action RPG, strategy, open world | Microsoft Windows | December 16, 2021 |
| Satisfactory | Coffee Stain Studios | Coffee Stain Publishing | Construction and management simulation | Microsoft Windows | March 19, 2019 |
| Scrapland | Mercury Steam Entertainment | Deep Silver, Enlight Software | Action-adventure | Microsoft Windows | November 4, 2004 |
| Scrolls | Mojang | Mojang | Tactical CCG | Microsoft Windows, macOS | November 11, 2014 |
| Secret of the Silver Blades | Strategic Simulations, Inc. | Strategic Simulations, Inc., Pony Canyon, Inc. | Fantasy, RPG | DOS, macOS, Commodore 64, Amiga, NEC PC-9801 | October 20, 1990 |
| The Secret World | Funcom | Electronic Arts | MMORPG | Microsoft Windows | July 3, 2012 |
| Sengoku | Paradox Development Studios | Paradox Interactive | Grand strategy | Microsoft Windows, macOS | September 13, 2011 |
| The Settlers | Blue Byte Software | Blue Byte Software | City-building game, Real-Time Strategy | Amiga, MS-DOS | June 30, 1993 |
| The Settlers II | Blue Byte Software | Blue Byte Software | City-building game, Real-Time Strategy | MS-DOS, Macintosh | April 17, 1996 |
| The Settlers III | Blue Byte Software | Blue Byte Software | City-building game, Real-Time Strategy | Microsoft Windows | November 20, 1998 |
| The Settlers IV | Blue Byte Software | Ubi Soft | City-building game, Real-Time Strategy | Microsoft Windows, | February 15, 2001 |
| The Settlers: Heritage of Kings | Blue Byte Software | Ubi Soft | City-building game, Real-Time Strategy | Microsoft Windows | November 25, 2004 |
| The Settlers II (10th Anniversary) | Blue Byte Software | Ubi Soft | City-building game, Real-Time Strategy | Microsoft Windows | November 7, 2006 |
| The Settlers: Rise of an Empire | Blue Byte Software | Ubi Soft | City-building game, Real-Time Strategy | Microsoft Windows | November 28, 2007 |
| The Settlers: Awakening of Cultures | Blue Byte Software | Ubi Soft | City-building game, Real-Time Strategy | Microsoft Windows | August 28, 2008 |
| The Settlers 7: Paths to a Kingdom | Blue Byte Software | Ubi Soft | City-building game, Real-Time Strategy | Microsoft Windows, macOS | March 25, 2010 |
| Shadow of the Tomb Raider | Eidos Montréal | Square Enix | action-adventure | Microsoft Windows | September 14, 2018 |
| The Ship | Outlight | Outlight | First-person shooter | Microsoft Windows | April 9, 2007 |
| Shogun: Total War | The Creative Assembly | Electronic Arts, Sega, Sold-Out Software | Turn-based strategy, real-time tactics | Microsoft Windows | June 13, 2000 |
| ShootMania Storm | Nadeo | Ubisoft | First-person shooter | Microsoft Windows | April 10, 2013 |
| Sid Meier's Railroads! | Firaxis Games, Feral Interactive | 2K Games, Feral Interactive | Business simulation | Microsoft Windows, macOS | October 17, 2006 |
| Silent Hunter | Aeon Electronic Entertainment | Strategic Simulations | Submarine simulator | DOS | 1996 |
| Silent Hunter II | Aeon Electronic Entertainment | Ubisoft | Submarine simulator | Microsoft Windows | November 6, 2001 |
| Silent Hunter III | Ubisoft Bucharest | Ubisoft | Submarine simulator | Microsoft Windows | March 15, 2005 |
| Silent Hunter 4: Wolves of the Pacific | Ubisoft Bucharest | Ubisoft | Submarine simulator | Microsoft Windows | March 20, 2007 |
| Silent Hunter 5: Battle of the Atlantic | Ubisoft Bucharest | Ubisoft | Submarine simulator | Microsoft Windows | March 2, 2010 |
| Silkroad Online | Joymax | Joymax, Yahoo! | MMORPG | Microsoft Windows | 2004 |
| Silver | Spiral House | Infogrames | Action RPG | Microsoft Windows | 1999 |
| SimCity | Maxis | Electronic Arts | City-building | Microsoft Windows, macOS | March 5, 2013 |
| SimCity 2000 | Maxis | Electronic Arts | City-building | Microsoft Windows, Various | 1994 |
| SimCity 3000 | Maxis | Electronic Arts | City-building | Microsoft Windows, Linux, macOS | January 31, 1999 |
| SimCity 4 | Maxis | Electronic Arts, Aspyr Media | City-building | Microsoft Windows, macOS | January 14, 2003 |
| SimCity Societies | Tilted Mill Entertainment | Electronic Arts | City-building | Microsoft Windows | November 13, 2007 |
| The Sims | Edge of Reality, Maxis | Electronic Arts | Life simulation | Microsoft Windows, Mac OS, OS X, Linux | February 11, 2000 |
| The Sims 2 | Maxis | Electronic Arts | Life simulation | Microsoft Windows, macOS | September 14, 2004 |
| The Sims 2: Apartment Life | Maxis | Electronic Arts | Life simulation | Microsoft Windows, macOS | August 25, 2008 |
| The Sims 2: Bon Voyage | Maxis | Electronic Arts | Life simulation | Microsoft Windows, macOS | September 4, 2007 |
| The Sims 2: FreeTime | Maxis | Electronic Arts | Life simulation | Microsoft Windows, macOS | February 22, 2008 |
| The Sims 2: Nightlife | Maxis | Electronic Arts | Life simulation | Microsoft Windows, macOS | September 13, 2005 |
| The Sims 2: Open for Business | Maxis | Electronic Arts | Life simulation | Microsoft Windows, macOS | March 6, 2006 |
| The Sims 2: Seasons | Maxis | Electronic Arts | Life simulation | Microsoft Windows, macOS | February 23, 2007 |
| The Sims 2: University | Maxis | Electronic Arts | Life simulation | Microsoft Windows, macOS | March 11, 2005 |
| The Sims 3 | Maxis | Electronic Arts | Life simulation | Microsoft Windows, macOS | June 2, 2009 |
| The Sims 3: Generations | Maxis | Electronic Arts | Life simulation | Microsoft Windows, macOS | May 31, 2011 |
| The Sims 3: Into the Future | Maxis | Electronic Arts | Life simulation | Microsoft Windows, macOS | October 22, 2013 |
| The Sims 3: Island Paradise | Maxis | Electronic Arts | Life simulation | Microsoft Windows, macOS | June 25, 2013 |
| The Sims 3: Late Night | Maxis | Electronic Arts | Life simulation | Microsoft Windows, macOS | October 26, 2010 |
| The Sims 3: Seasons | Maxis | Electronic Arts | Life simulation | Microsoft Windows, macOS | November 13, 2012 |
| The Sims 3: Showtime | Maxis | Electronic Arts | Life simulation | Microsoft Windows, macOS | March 6, 2012 |
| The Sims 3: Supernatural | Maxis | Electronic Arts | Life simulation | Microsoft Windows, macOS | September 4, 2012 |
| The Sims 3: University Life | Maxis | Electronic Arts | Life simulation | Microsoft Windows, macOS | March 5, 2013 |
| The Sims: Hot Date | Maxis | Electronic Arts | Life simulation | Microsoft Windows, macOS | November 14, 2001 |
| The Sims: House Party | Maxis | Electronic Arts | Life simulation | Microsoft Windows, macOS | April 2, 2001 |
| The Sims: Livin' Large | Maxis | Electronic Arts, Aspyr | Life simulation | Microsoft Windows, macOS | August 27, 2000 |
| The Sims: Makin' Magic | Maxis | Electronic Arts | Life simulation | Microsoft Windows, macOS | October 29, 2003 |
| The Sims: Superstar | Maxis | Electronic Arts | Life simulation | Microsoft Windows, macOS | May 13, 2003 |
| The Sims: Unleashed | Maxis | Electronic Arts | Life simulation | Microsoft Windows, macOS | January 7, 2002 |
| The Sims: Vacation | Maxis | Electronic Arts | Life simulation | Microsoft Windows, macOS | March 28, 2002 |
| Sins of a Solar Empire | Ironclad Games | Stardock | RTS | Microsoft Windows | 2008 |
| Sleeping Dogs | United Front Games | Square Enix | Action-adventure | Microsoft Windows | September 14, 2012 |
| Smite | Hi-Rez Studios | Hi-Rez Studios | MOBA | Microsoft Windows | March 25, 2014 |
| Sonic Heroes | Sonic Team USA | Sega | platform | Microsoft Windows | December 5, 2003 |
| Sonic & Knuckles Collection | Sega PC | Sega | platform, compilation | Microsoft Windows | 1997 |
| Space Engineers | Keen Software House | Keen Software House | Sandbox, simulation | Microsoft Windows | October 23, 2013 |
| Space Station 13 | SS13 Development Team | SS13 Development Team | MMORPG | Microsoft Windows | February 16, 2003 |
| SpaceChem | Zachtronics Industries | Zachtronics Industries | Puzzle | Microsoft Windows, Linux, macOS | January 1, 2011 |
| Marvel's Spider-Man Remastered | Insomniac Games | Sony Interactive Entertainment | Action-adventure | Microsoft Windows | August 12, 2022 |
| Marvel's Spider-Man 2 | Insomniac Games | Sony Interactive Entertainment | Action-adventure | Microsoft Windows | January 30, 2025 |
| Marvel's Spider-Man: Miles Morales | Insomniac Games | Sony Interactive Entertainment | Action-adventure | Microsoft Windows | November 18, 2022 |
| Spore | Maxis | Electronic Arts | Life simulation | Microsoft Windows | September 7, 2008 |
| Spore Galactic Adventures | Maxis | Electronic Arts | Life simulation | Microsoft Windows | June 23, 2009 |
| S.T.A.L.K.E.R.: Call of Pripyat | GSC Game World | Viva Media | First-person shooter | Microsoft Windows | February 2, 2010 |
| S.T.A.L.K.E.R.: Clear Sky | GSC Game World | Deep Silver | First-person shooter | Microsoft Windows | September 15, 2008 |
| S.T.A.L.K.E.R.: Shadow of Chernobyl | GSC Game World | THQ | First-person shooter | Microsoft Windows | March 20, 2007 |
| The Stanley Parable | Galactic Cafe | Galactic Cafe | Interactive fiction | Microsoft Windows, Linux, macOS | October 17, 2013 |
| Starbound | Chucklefish | Chucklefish | Action-adventure, first-person shooter | Microsoft Windows, OS X, Linux | July 22, 2016 |
| Star Citizen | Cloud Imperium Games Corporation | Cloud Imperium Games Corporation | Space trading and combat simulator, first-person shooter | Microsoft Windows, Linux | TBA |
| Star Trek Online | Cryptic Studios | Perfect World Entertainment | MMORPG | Microsoft Windows, macOS | February 2, 2010 |
| Star Wars: Empire At War | Petroglyph Games | LucasArts | Real-time strategy | Microsoft Windows, macOS | February 16, 2006 |
| Star Wars Galaxies | Sony Online Entertainment | Electronic Arts, LucasArts | MMORPG | Microsoft Windows | February 17, 2006 |
| Star Wars: Knights of the Old Republic | BioWare | LucasArts | RPG | Microsoft Windows, macOS | November 19, 2003 |
| Star Wars: Knights of the Old Republic II – The Sith Lords | Obsidian Entertainment | LucasArts | RPG | Microsoft Windows, Linux, macOS | February 8, 2005 |
| Star Wars: Republic Commando | LucasArts, Magellan Interactive | THQ Wireless | Tactical shooter, first-person shooter | Xbox, Microsoft Windows | February 17, 2005 |
| Star Wars: The Old Republic | BioWare | Electronic Arts, LucasArts | MMORPG | Microsoft Windows | December 20, 2011 |
| Star Wars: TIE Fighter | Lucasarts | Lucasarts | Flight simulation | DOS, Windows 9x, Linux, macOS | July 1, 1994 |
| Star Wars: X-Wing | Lucasarts | Lucasarts | Flight simulation | DOS, macOS | February 1, 1993 |
| StarCraft | Blizzard Entertainment | Blizzard Entertainment | RTS | Microsoft Windows, macOS | March 31, 1998 |
| StarCraft: Brood War | Blizzard Entertainment Saffire | Blizzard Entertainment | RTS | Microsoft Windows, macOS | November 30, 1998 |
| StarCraft II: Heart of the Swarm | Blizzard Entertainment | Blizzard Entertainment | RTS | Microsoft Windows, macOS | March 12, 2013 |
| StarCraft II: Legacy of the Void | Blizzard Entertainment | Blizzard Entertainment | RTS | Microsoft Windows, macOS | November 10, 2015 |
| StarCraft II: Wings of Liberty | Blizzard Entertainment | Blizzard Entertainment | RTS | Microsoft Windows, macOS | July 27, 2010 |
| Stardew Valley | Eric Barone | ChuckleFish, ConcernedApe | Farming simulation, RPG | Microsoft Windows, OS X, Linux | February 26, 2016 |
| StarDrive | Zero Sum Games | Iceberg Interactive | 4X, strategy | Microsoft Windows | April 26, 2013 |
| Starsector | Fractal Softworks [1] | Fractal Softworks | 4X, strategy, action RPG | Microsoft Windows, Linux, macOS | April 26, 2013 |
| Starsiege: Tribes | Dynamix | Sierra On-Line | First-person shooter | Microsoft Windows | December 23, 1998 |
| State of Decay | Undead Labs | Microsoft Studios | Stealth, survival horror, RPG, third-person shooter, simulation | Microsoft Windows | November 5, 2013 |
| Stellar Monarch | Silver Lemur Games | Silver Lemur Games | 4X, strategy | Microsoft Windows | December 5, 2016 |
| The Sting! | Neo Software | JoWooD Entertainment | Strategy, adventure | Microsoft Windows | July 1, 2001 |
| Street Racing Syndicate | Eutechnyx | Namco | Racing | Windows | October 4, 2005 |
| Stronghold | Firefly Studios, MacSoft | Take 2 Interactive, God Games | RTS | Microsoft Windows, macOS | October 19, 2001 |
| Stronghold 2 | Firefly Studios | 2K Games | RTS | Microsoft Windows | April 18, 2005 |
| Stronghold 3 | Firefly Studios | 7Sixty Games | RTS | Microsoft Windows, Linux, macOS | October 25, 2011 |
| Stronghold: Crusader | Firefly Studios | Take 2 Interactive, God Games | RTS | Microsoft Windows | July 31, 2002 |
| Stronghold: Crusader Extreme | Firefly Studios | Gamecock Media Group | RTS | Microsoft Windows | May 27, 2008 |
| Stronghold Kingdoms | Firefly Studios | Firefly Studios | RTS | Microsoft Windows | October 17, 2012 |
| Stronghold Legends | Firefly Studios | 2K Games | RTS | Microsoft Windows | October 13, 2006 |
| Subnautica | Unknown Worlds Entertainment | Unknown Worlds Entertainment | Action-adventure, survival horror | Microsoft Windows,macOS | December 16, 2014 |
| Subnautica: Below Zero | Unknown Worlds Entertainment | Unknown Worlds Entertainment | Action-adventure, survival horror | Microsoft Windows,macOS | May 14, 2021 |
| Sunset Overdrive | Insomniac Games | Microsoft Studios | Action-adventure, third-person shooter | Microsoft Windows | November 16, 2018 |
| Super Meat Boy | Team Meat | Team Meat | Platformer | Microsoft Windows, Linux, macOS | April 5, 2011 |
| SUPERHOT | SUPERHOT team | SUPERHOT team | First-person shooter | Microsoft Windows, Linux, macOS | February 25, 2016 |
| Supreme Commander | Gas Powered Games | THQ | RTS | Microsoft Windows | February 16, 2007 |
| Surf's Up | Ubisoft Montreal, Ubisoft Quebec, Totally Games | Ubisoft, Sony Computer Entertainment America | Sports | Mac OS X, Microsoft Windows | May 30, 2007 |
| SWAT 3: Close Quarters Battle | Sierra Northwest | Sierra Entertainment | First-person shooter, tactical shooter | Microsoft Windows | November 23, 1999 |
| SWAT 4 | Irrational Games | Vivendi Universal Games, Sierra Entertainment | First-person shooter, tactical shooter | Microsoft Windows, macOS | April 5, 2005 |
| System Shock | Looking Glass Studios | Origin Systems | Action-adventure, RPG | DOS, macOS | October 22, 1994 |
| System Shock 2 | Irrational Games, Looking Glass Studios | Electronic Arts | Action RPG, survival horror | Microsoft Windows, Linux, macOS | August 11, 1999 |