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United States Senate elections in Wyoming occur when voters in Wyoming select an individual to represent the state in the United States Senate in either of the state's two seats allotted by the U.S. Constitution. Regularly scheduled general elections occur on Election Day, coinciding with various other federal, statewide, and local races.
| Year | Democratic | Votes | Pct | Republican | Votes | Pct | |
|---|---|---|---|---|---|---|---|
| 1988 | John Vinich | 89,821 | 49.6% | Malcolm Wallop (inc.) | 91,143 | 50.4% | |
| 1990 | Kathy Helling | 56,848 | 36% | Al Simpson (inc.) | 100,784 | 64% | |
| 1994 | Mike Sullivan | 79,287 | 39% | Craig L. Thomas | 118,754 | 59% | |
| 1996 | Kathy Karpan | 89,103 | 42% | Mike Enzi | 114,116 | 54% | |
| 2000 | Mel Logan | 47,087 | 22% | Craig L. Thomas (inc.) | 157,622 | 74% | |
| 2002 | Joyce Corcoran | 49,570 | 27% | Mike Enzi (inc.) | 133,710 | 73% | |
| 2006 | Dale Groutage | 57,671 | 30% | Craig L. Thomas (inc.) | 135,174 | 70% | |
| 2008 (Special) | Nick Carter | 66,202 | 27% | John Barrasso (inc.) | 183,063 | 73% | |
| 2008 | Chris Rothfuss | 60,631 | 24% | Mike Enzi (inc.) | 189,046 | 76% | |
| 2012 | Tim Chesnut | 52,596 | 22% | John Barrasso (inc.) | 184,531 | 76% | |
| 2014 | Charlie Hardy | 29,377 | 17% | Mike Enzi (inc.) | 121,554 | 72% | |
| 2018 | Gary Trauner | 61,227 | 30% | John Barrasso (inc.) | 136,210 | 67% | |
| 2020 | Merav Ben-David | 72,766 | 26% | Cynthia Lummis | 198,100 | 72% | |