Notable earthquakes in the history of Panama include the following:
| Date | Region | Mag. | MMI | Deaths | Injuries | Comments | |
|---|---|---|---|---|---|---|---|
| 2009-07-04 | Panama / Costa Rica | 6 Mw | V | 32 | Limited damage | NGDC (1972) | |
| 2004-02-04 | Panama / Costa Rica | 6.1 Mw | Very many | Limited damage | NGDC (1972) | ||
| 2003-12-25 | Puerto Armuelles | 6.5 Mw | VII | 2 | 75 | Moderate damage | |
| 2002-07-30 | Burica Peninsula | 6.5 Mw | VII | 11–15 | Moderate damage | ||
| 2000-11-08 | Panama / Colombia | 6.5 Mw | Some | Moderate damage | NGDC (1972) | ||
| 1991-05-04 | Bocas del Toro Province | 6.2 Ms | 36 | Moderate damage | NGDC (1972) | ||
| 1991-04-22 | Costa Rica / Panama | 7.7 Mw | IX | 75–87 | 563–759 | Extreme damage | |
| 1983-04-03 | Costa Rica / Panama | 7.3 Ms | 6 | Some | Moderate damage | NGDC (1972) | |
| 1941-12-05 | Costa Rica / Panama | 7.6 Ms | IV | 6 | Many | Moderate damage / tsunami | NGDC (1972) |
| 1934-07-18 | Panama / Costa Rica | 7.7 Ms | VII | 4 | Limited damage / tsunami | NGDC (1972) | |
| 1882-09-07 | San Blas Islands | 8.3 Ms | XI | Severe damage / tsunami | NGDC (1972) | ||
| 1621-05-02 | 6.9 ML | VII | Moderate damage / tsunami | ||||
| Note: The inclusion criteria for adding events are based on WikiProject Earthquakes' notability guideline that was developed for stand alone articles. The principles described also apply to lists. In summary, only damaging, injurious, or deadly events should be recorded. | |||||||