 | This article may have been created or edited in return for undisclosed payments, a violation of Wikipedia's terms of use. It may require cleanup to comply with Wikipedia's content policies, particularly neutral point of view. (September 2017) |
Lunasin is a peptide found in soy and some cereal grains that, since 1996, has been the subject of research focusing on cancer, cholesterol and cardiovascular disease and inflammation. [1]
Lunasin is a peptide that can be found in soy, barley, wheat, [2] and rye. It is also found in grains originating in the American continents, such as Amaranthus hypochondriacus . [3] This polypeptide was originally isolated, purified, and sequenced from soybean seed in 1987. Although uncertain about the peptide’s biological activity, the Japanese team of researchers described it as a 43-amino acid peptide, noting specifically the unusual poly (L-aspartic acid) sequence at the carboxyl terminus. [4] [5] Subsequent research by Alfredo Galvez in the laboratory of Ben de Lumen at the University of California–Berkeley identified the peptide as a subunit of the cotyledon-specific 2S albumin. [6] The name of the protein was chosen from the Filipino word lunas, which means "cure". [7] [8] Lunasin was patented as a biologic molecule in 1999 by de Lumen and Galvez. [9]
The biological activity of lunasin was discovered by Galvez while working in the laboratory of de Lumen at UC Berkeley. [10]
There has been much research interest in the biomedical aspects of lunasin but the high cost of synthesizing lunasin made experimentation difficult. [11] This limitation has been overcome by the development of methods to isolate highly purified lunasin from soybean white flake, a byproduct of soybean processing. [12] In laboratory and animal experiments lunasin has shown anti-carcinogenic activity that suggests it may have chemopreventive potential. [13]
In 2014, a local news program reported that a person with ALS named Mike McDuff had experienced dramatic improvements in speech, swallowing and limb strength while taking a supplement regimen containing lunasin. [14] ALSUntangled [15] investigated and was able to confirm that Mike McDuff had progressive muscular atrophy, a "lower motor neuron" form of ALS, and really did experience dramatic and objective improvements. [16] Since one possible explanation for these improvements was the use of lunasin, Dr. Richard Bedlack of the Duke ALS Clinic decided to perform a clinical trial. Fifty people with ALS were put on the exact Lunasin containing regimen that Mike McDuff had taken and were followed for a year. The trial finished in September 2017. Unfortunately, there was no evidence that lunasin slowed, stopped or reversed ALS in any of the trial participants. Gastrointestinal side effects were more common than expected in trial participants, including cases of constipation severe enough to warrant hospitalization. [17] Bedlack concluded that lunasin was not a useful treatment for ALS and that Mike McDuff likely had some other explanation for his ALS reversal such as an ALS mimic syndrome or a genetic resistance to the disease. [18]
Lunasin was the first dietary compound with an identified epigenetic mechanism of action. This mechanism (histone acetylation) was identified by Alfredo Galvez in 1996 and patented in 1999.
A protease is an enzyme that catalyzes proteolysis, breaking down proteins into smaller polypeptides or single amino acids, and spurring the formation of new protein products. They do this by cleaving the peptide bonds within proteins by hydrolysis, a reaction where water breaks bonds. Proteases are involved in many biological functions, including digestion of ingested proteins, protein catabolism, and cell signaling.
The soybean, soy bean, or soya bean is a species of legume native to East Asia, widely grown for its edible bean, which has numerous uses.
Aspartic acid (symbol Asp or D; the ionic form is known as aspartate), is an α-amino acid that is used in the biosynthesis of proteins. Like all other amino acids, it contains an amino group and a carboxylic acid. Its α-amino group is in the protonated –NH+
3 form under physiological conditions, while its α-carboxylic acid group is deprotonated −COO− under physiological conditions. Aspartic acid has an acidic side chain (CH2COOH) which reacts with other amino acids, enzymes and proteins in the body. Under physiological conditions (pH 7.4) in proteins the side chain usually occurs as the negatively charged aspartate form, −COO−. It is a non-essential amino acid in humans, meaning the body can synthesize it as needed. It is encoded by the codons GAU and GAC.
Histone deacetylases (EC 3.5.1.98, HDAC) are a class of enzymes that remove acetyl groups (O=C-CH3) from an ε-N-acetyl lysine amino acid on both histone and non-histone proteins. HDACs allow histones to wrap the DNA more tightly. This is important because DNA is wrapped around histones, and DNA expression is regulated by acetylation and de-acetylation. HDAC's action is opposite to that of histone acetyltransferase. HDAC proteins are now also called lysine deacetylases (KDAC), to describe their function rather than their target, which also includes non-histone proteins.
Phytic acid is a six-fold dihydrogenphosphate ester of inositol, also called inositol hexakisphosphate (IP6) or inositol polyphosphate. At physiological pH, the phosphates are partially ionized, resulting in the phytate anion.
Crocin is a carotenoid chemical compound that is found in the flowers of crocus and gardenia. Its oxygen content also chemically makes it a xanthene. Crocin is the chemical primarily responsible for the color of saffron.
Soy protein is a protein that is isolated from soybean. It is made from soybean meal that has been dehulled and defatted. Dehulled and defatted soybeans are processed into three kinds of high protein commercial products: soy flour, concentrates, and isolates. Soy protein isolate has been used since 1959 in foods for its functional properties.
Aspartic proteases are a catalytic type of protease enzymes that use an activated water molecule bound to one or more aspartate residues for catalysis of their peptide substrates. In general, they have two highly conserved aspartates in the active site and are optimally active at acidic pH. Nearly all known aspartyl proteases are inhibited by pepstatin.
N-Acetylaspartylglutamic acid is a peptide neurotransmitter and the third-most-prevalent neurotransmitter in the mammalian nervous system. NAAG consists of N-acetylaspartic acid (NAA) and glutamic acid coupled via a peptide bond.
Caspase-3 is a caspase protein that interacts with caspase-8 and caspase-9. It is encoded by the CASP3 gene. CASP3 orthologs have been identified in numerous mammals for which complete genome data are available. Unique orthologs are also present in birds, lizards, lissamphibians, and teleosts.
Histone deacetylase inhibitors are chemical compounds that inhibit histone deacetylases.
The discovery of an orally inactive peptide from snake venom established the important role of angiotensin converting enzyme (ACE) inhibitors in regulating blood pressure. This led to the development of captopril, the first ACE inhibitor. When the adverse effects of captopril became apparent new derivates were designed. Then after the discovery of two active sites of ACE: N-domain and C-domain, the development of domain-specific ACE inhibitors began.
In enzymology, an alpha-tubulin N-acetyltransferase is an enzyme which is encoded by the ATAT1 gene.
Cathepsin D is a protein that in humans is encoded by the CTSD gene. This gene encodes a lysosomal aspartyl protease composed of a protein dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. Cathepsin D is an aspartic endo-protease that is ubiquitously distributed in lysosomes. The main function of cathepsin D is to degrade proteins and activate precursors of bioactive proteins in pre-lysosomal compartments. This proteinase, which is a member of the peptidase A1 family, has a specificity similar to but narrower than that of pepsin A. Transcription of the CTSD gene is initiated from several sites, including one that is a start site for an estrogen-regulated transcript. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease. Homozygous deletion of the CTSD gene leads to early lethality in the postnatal phase. Deficiency of CTSD gene has been reported an underlying cause of neuronal ceroid lipofuscinosis (NCL).
Renin inhibitors are pharmaceutical drugs inhibiting the activity of renin that is responsible for hydrolyzing angiotensinogen to angiotensin I, which in turn reduces the formation of angiotensin II that facilitates blood pressure.
Plant defensins are a family of small, cysteine-rich defensins found in plants that serve to defend them against pathogens and parasites.
Kunitz soybean trypsin inhibitor is a type of protein contained in legume seeds which functions as a protease inhibitor. Kunitz-type Soybean Trypsin Inhibitors are usually specific for either trypsin or chymotrypsin. They are thought to protect seeds against consumption by animal predators.
In molecular biology, the Bowman–Birk protease inhibitor family of proteins consists of eukaryotic proteinase inhibitors, belonging to MEROPS inhibitor family I12, clan IF. They mainly inhibit serine peptidases of the S1 family, but also inhibit S3 peptidases.
Scytalidocarboxyl peptidase B, also known as Scytalidoglutamic peptidase and Scytalidopepsin B is a proteolytic enzyme. It was previously thought to be an aspartic protease, but determination of its molecular structure showed it to belong a novel group of proteases, glutamic protease.
Elvira de Mejia is a biochemist and food scientist, currently working as a professor of Food Sciences and Human Nutrition at the University of Illinois at Urbana–Champaign. She is an expert in the areas of food science, food toxicology, and chemoprevention.
Soy (Glycine max) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| General |  | ||||||||||||
| Soy-based dishes | |||||||||||||
| Plant milk | |||||||||||||
| Meat analogues | |||||||||||||
| Sauces and condiments |
| ||||||||||||
| Other foods | |||||||||||||
| Biochemicals |
| ||||||||||||
| Companies | |||||||||||||
| Other |
| ||||||||||||
