Manuel Casanova | |
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Born | Manuel Casanova |
Nationality | American |
Alma mater | Johns Hopkins |
Known for | SmartState Chair in Childhood neurotherapeutics |
Awards | The Outstanding Scholar Award Frontiers Media Spotlight Award |
Scientific career | |
Fields | Childhood Neurotherapeutics |
Institutions | University of South Carolina Greenville |
Website | corticalchauvinism |
Notes | |
Son-in-law, Matt Might [1] |
Manuel F. Casanova is the SmartState Endowed Chair in Childhood Neurotherapeutics and a professor of Biomedical Sciences at the University of South Carolina School of Medicine Greenville. He is a former Gottfried and Gisela Kolb Endowed Chair in Outpatient Psychiatry and a Professor of Anatomical Sciences and Neurobiology at the University of Louisville. [2]
Casanova has four daughters: Cristina, Sabrina, Belinda, and Melina. Cristina Casanova Might is the Founder and President of the NGLY1 Foundation [3] and the Executive Director at the Undiagnosed Diseases Network Foundation (UDNF). [4] He is married to Emily Casanova, a research assistant professor at the University of South Carolina School of Medicine Greenville [5] who studies autism genetics, the evolution of susceptibility genes in rare disorders, and is a patient advocate for the Ehlers-Danlos community. [6] His son-in-law is Matt Might, director of the Hugh Kaul Personalized Medicine Institute at the University of Alabama Birmingham. [1] Casanova has a personal blog titled "Cortical Chauvinism". [7]
Casanova earned his medical degree from the University of Puerto Rico. He then completed clinical and research fellowships at Johns Hopkins University School of Medicine, including three years in neuropathology, where he was in-charge of pediatric neuropathology, which was when his interest in developmental disorders of the brain arose. He subsequently helped establish two brain banks, the Johns Hopkins Brain Resource Center and the Brain Bank Unit of the Clinical Brains Disorders Branch at the National Institute of Mental Health (NIMH).
Casanova spent several years as a deputy medical examiner for Washington, D.C., where he gained experience with the postmortem examination of sudden infant death syndrome and child abuse, which was when he began publishing extensively on postmortem techniques, including neuronal morphometry immunocytochemistry, neurochemistry, and autoradiography. He also worked as a consultant and was staff neuropathologist at Sinai Hospital in Maryland, the North Charles Hospital, and the D.C. General Hospital. He is also a former lieutenant commander in the US Public Health Service. After serving as a professor of psychiatry and neurology at the Medical College of Georgia, he subsequently joined the University of Louisville faculty. In June 2014, he moved to the University of South Carolina and the Greenville Health System. [2]
Casanova's recent research projects have examined brain abnormalities in patients with neurodevelopmental disorders, including autism spectrum disorders and dyslexia. His interest has gradually come to focus on abnormalities of cortical neurocircuitry, in particular on the cell minicolumn, a vertical conglomerate of eighty to one hundred neurons that have in common a latency of response to stimulation. [8] [9] Using computerized imaging analysis, he has established the anatomical validity of the cell minicolumn. Casanova has reported interhemispheric differences in the morphometry of minicolumns that could provide explanations for the speciation of hominids. Localized in Brodmann area 22—part of Wernicke’s language region—the morphometric difference may play a role both in the development of language and in related disorders. [7]
His neuromorphology research, conducted in collaboration with other researchers from around the globe, has found there are drastic differences in the brains of autistic individuals. The studies that he conducted show that minicolumns (or 'brain strands') of autism spectrum individuals have more cells, but they are narrower and more densely packed, which he says can limit the brain's ability to send messages. [10] Casanova claimed this helps explain symptoms since "there's not enough juice to actually power very long connections in the brain". [11]
Casanova has also been studying the autonomic nervous system in autistic individuals. He found that the sympathetic branch of the ANS is overactive in autistic children, which leads to higher levels of anxiety. Additionally, he believes that TMS and neurofeedback can reduce autonomic dysfunction that is linked to certain foods. [12]
Casanova notes that one of the problems with brain banks is that preserved brain tissue can deteriorate over time, but claims that brain banks promote far more research insight than MRI scans. [13]
His expertise in the field of postmortem techniques was recognized by honorary appointments as a Scientific Expert for the Armed Forces Institute of Pathology and as a Professorial Lecturer for the Department of Forensic Science at George Washington University. [14]
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Neurodiversity paradigm |
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Casanova has stated that most of the neurodiversity movement is based on the good intention to destigmatize autism, but some of their scientific arguments are questionable. [18] He sees many other positives in the movement, such as the desire for acceptance and accommodations. [19] Casanova states that the concepts behind neurodiversity originated in ancient Greek times, when Socrates attempted to determine which behaviors were a disorder and which ones were simply differences. According to him, those ideas were also seen in the Renaissance, the Romantic era, and the antipsychiatry movement. He further claims that Leo Kanner originated the modern version of the neurodiversity movement through studying autistic individuals. [20] [21]
However, he says that the loudest voices in the neurodiversity camp are disruptive. Casanova claimed about their views that “They see the world in black and white, and either you are with them or against them” and “it might end up hurting research, and hurting the delivery of services to those people who most need them.” Additionally, he said “It’s not a blessing to have head-banging, eye-gouging or self-biting; those have serious side effects, including retinal detachment, cauliflower ears, they can get brain trauma, contusions. ”. [19]
In response to neurodiversity's statement that autism does not need medical treatment, Casanova points out that parents that support therapy or treatment for autistic children say that it will reduce their suffering and give them the best chance to succeed in adulthood,. [21] Casanova additionally claimed that until recently, the neurodiversity movement wilfully neglected the roles of Leo Kanner and Bernard Rimland in advocating for accommodations, claiming that they were ignored because those individuals also wanted medical treatments for autism. [20]
Casanova has also claimed that Neurotribes by Steve Silberman was unfairly weighted against Leo Kanner. [22] Casanova has also written against Silberman's apparent perspective that Hans Asperger, one of the first autism researchers, should be forgiven for his involvement in the Nazi regime. "Contrary to Mr. Silberman," Casanova wrote in response, "I do not defend or condone [Asperger’s] murderous actions." [23] He has also chosen to ignore the existence of Silberman's 2018 revision of Neurotribes , in which the author acknowledged Asperger's crimes.
Casanova claims that some media sources have misrepresented his views on autism and neurodiversity. One article from WAVE 3 claimed that Casanova wanted to wipe out autism entirely [11] when he said that was not true. Additionally, a Newsweek article claimed that Casanova received death threats from writing about autism, but this actually happened because some autistic individuals falsely thought he wanted to wipe out autism based on the WAVE 3 article. [24] [25]
Asperger syndrome (AS), also known as Asperger's syndrome or Asperger's, is a term formerly used to describe a neurodevelopmental disorder characterized by significant difficulties in social interaction and nonverbal communication, along with restricted, repetitive patterns of behavior and interests. Asperger syndrome has been merged with other disorders into autism spectrum disorder (ASD) and is no longer considered a stand-alone diagnosis. It was considered milder than other diagnoses which were merged into ASD due to relatively unimpaired spoken language and intelligence.
Lorna Gladys Wing was an English psychiatrist. She was a pioneer in the field of childhood developmental disorders, who advanced understanding of autism worldwide, introduced the term Asperger syndrome in 1976 and was involved in founding the National Autistic Society (NAS) in the UK.
Diagnoses of autism have become more frequent since the 1980s, which has led to various controversies about both the cause of autism and the nature of the diagnoses themselves. Whether autism has mainly a genetic or developmental cause, and the degree of coincidence between autism and intellectual disability, are all matters of current scientific controversy as well as inquiry. There is also more sociopolitical debate as to whether autism should be considered a disability on its own.
Sir Simon Philip Baron-Cohen is a British clinical psychologist and professor of developmental psychopathology at the University of Cambridge. He is the director of the university's Autism Research Centre and a Fellow of Trinity College.
Neurodiversity is a framework for understanding human brain function that recognizes the diversity of human cognition as a biological fact. The neurodiversity paradigm argues that diversity in human cognition is normal and that some conditions classified as mental disorders are differences and disabilities that are not necessarily pathological.
The autism rights movement, also known as the autistic acceptance movement, is a social movement allied with disability rights that emphasizes a neurodiversity paradigm, viewing autism as a disability with variations in the human brain rather than as a disease to be cured. The movement advocates for several goals, including greater acceptance of autistic traits and behaviors; reforms of services - i.e. services that focus on improving quality of life and well-being instead of suppression and masking of autistic traits that are adaptive or not harmful or imitations of social behaviors of allistic (non-autistic) peers ; the creation of social networks and events that allow autistic people to socialize on their own terms; and the recognition of the autistic community as a minority group.
The refrigerator mother theory, also known as Bettelheim's theory of autism, is a largely abandoned psychological fringe theory that the cause of autism is a lack of parental, and in particular, maternal emotional warmth. Evidence against the refrigerator mother theory began in the late 1970s, with twin studies suggesting a genetic etiology, as well as various environmental factors. Modern research generally agrees that there is a largely epigenetic etiology of autism spectrum disorders.
The following outline is provided as an overview of and topical guide to autism:
Societal and cultural aspects of autism or sociology of autism come into play with recognition of autism, approaches to its support services and therapies, and how autism affects the definition of personhood. The autistic community is divided primarily into two camps; the autism rights movement and the pathology paradigm. The pathology paradigm advocates for supporting research into therapies, treatments, and/or a cure to help minimize or remove autistic traits, seeing treatment as vital to help individuals with autism, while the neurodiversity movement believes autism should be seen as a different way of being and advocates against a cure and interventions that focus on normalization, seeing it as trying to exterminate autistic people and their individuality. Both are controversial in autism communities and advocacy which has led to significant infighting between these two camps. While the dominant paradigm is the pathology paradigm and is followed largely by autism research and scientific communities, the neurodiversity movement is highly popular among most autistic people, within autism advocacy, autism rights organizations, and related neurodiversity approaches have been rapidly growing and applied in the autism research field in the last few years.
Asperger syndrome (AS) was formerly a separate diagnosis under autism spectrum disorder. Under the DSM-5 and ICD-11, patients formerly diagnosable with Asperger syndrome are diagnosable with Autism Spectrum Disorder. The term is considered offensive by some autistic individuals. It was named after Hans Asperger (1906–80), who was an Austrian psychiatrist and pediatrician. An English psychiatrist, Lorna Wing, popularized the term "Asperger's syndrome" in a 1981 publication; the first book in English on Asperger syndrome was written by Uta Frith in 1991 and the condition was subsequently recognized in formal diagnostic manuals later in the 1990s.
Classic autism, also known as childhood autism, autistic disorder, (early) infantile autism, infantile psychosis, Kanner's autism, Kanner's syndrome, or (formerly) just autism, is a neurodevelopmental condition first described by Leo Kanner in 1943. It is characterized by atypical and impaired development in social interaction and communication as well as restricted, repetitive behaviors, activities, and interests. These symptoms first appear in early childhood and persist throughout life.
Autism, also called autism spectrum disorder (ASD) or autism spectrum condition (ASC), is a neurodevelopmental disorder marked by restricted and repetitive patterns of behavior and deficits in reciprocal social communication. Other common signs include perseverative interests, stereotypic body movements (stimming), rigid routines, hyper- or hyporeactivity to sensory input, and difficulty with social interaction and verbal and nonverbal communication. Autism is clinically regarded as a spectrum disorder, meaning that it can manifest very differently in each person. For example, some are nonspeaking, while others have proficient spoken language. Because of this, there is wide variation in the support needs of people across the autism spectrum.
Geraldine Dawson is an American child clinical psychologist, specializing in autism. She has conducted research on early detection, brain development, and treatment of autism spectrum disorders (ASD) and collaborated on studies of genetic risk factors in autism. Dawson is William Cleland Distinguished Professor of Psychiatry and Behavioral Sciences and professor of psychology and neuroscience, former director, Duke Institute for Brain Sciences and founding director of the Duke Center for Autism and Brain Development at Duke University Medical Center. Dawson was president of the International Society for Autism Research, a scientific and professional organization devoted to advancing knowledge about autism spectrum disorders. From 2008 to 2013, Dawson was research professor of psychiatry at the University of North Carolina at Chapel Hill and was chief science officer for Autism Speaks. Dawson also held the position of adjunct professor of psychiatry at Columbia University and is professor emerita of psychology at University of Washington. She is a fellow of the American Psychological Society, American Psychological Association, International Society for Autism Research, and the Society of Clinical Child and Adolescent Psychology.
Eric Courchesne is an autism researcher and Professor of Neurosciences in University of California, San Diego School of Medicine and Director of the UCSD Autism Center located in La Jolla, California.
Jonathan Mitchell is an American author and autistic blogger who writes about autism including the neuroscience of the disorder and neurodiversity movement. His novel The Mu Rhythm Bluff is about a 49-year-old autistic man who undergoes transcranial magnetic stimulation.
The history of autism spans over a century; autism has been subject to varying treatments, being pathologized or being viewed as a beneficial part of human neurodiversity. The understanding of autism has been shaped by cultural, scientific, and societal factors, and its perception and treatment change over time as scientific understanding of autism develops.
NeuroTribes: The Legacy of Autism and the Future of Neurodiversity is a book by Steve Silberman that discusses autism and neurodiversity from historic, scientific, and advocacy-based perspectives. Neurotribes was awarded the Samuel Johnson Prize in 2015, and has received wide acclaim from both the scientific and the popular press. It was named to a number of "best books of 2015" lists, including The New York Times Book Review and The Guardian.
In a Different Key: The Story of Autism is a 2016 non-fiction book by John Donvan and Caren Zucker. It discusses the history of autism and autism advocacy, including issues such as the Refrigerator mother theory and the possibility of an autism epidemic. Donald Triplett, perhaps the first person diagnosed with autism, and psychiatrist Leo Kanner are also covered, as is the ongoing debate concerning the neurodiversity movement, especially with respect to autistic people with more apparent support needs.
Jonathan Green is a British professor of child and adolescent psychiatry at the University of Manchester. He is a specialist in autism spectrum disorders. He co-led the first study in the United Kingdom into ICD Asperger syndrome and has written research studies about social and language development in Autism Spectrum Disorder, co-morbidity and treatment intervention.
The Interagency Autism Coordinating Committee (IACC) is a United States federal advisory panel within the Department of Health and Human Services (HHS). It coordinates all efforts within HHS concerning autism spectrum disorder (ASD).