Melanoma inhibitory activity

MIA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1HJD, 1I1J, 1K0X
Identifiers
Aliases	MIA , CD-RAP, Melanoma inhibitory activity, MIA SH3 domain containing
External IDs	OMIM: 601340; MGI: 109615; HomoloGene: 4763; GeneCards: MIA; OMA:MIA - orthologs
Gene location (Mouse) Chr. Chromosome 7 (mouse) [1] Band 7 A3|7 15.84 cM Start 26,879,167 bp [1] End 26,880,582 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibial nerve pituitary gland anterior pituitary sural nerve salivary gland minor salivary glands skin of abdomen left coronary artery appendix canal of the cervix Top expressed in cartilage of bone long bone rib neurocranium chondrocranium femur humerus lower leg sphenoid bone occiput More reference expression data BioGPS n/a
Gene ontology Molecular function growth factor activity Cellular component extracellular region extracellular space Biological process cell population proliferation regulation of signaling receptor activity signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8190 12587 Ensembl n/a ENSMUSG00000089661 UniProt Q16674 Q61865 RefSeq (mRNA) NM_006533 NM_001202553 NM_019394 RefSeq (protein) NP_001189482 NP_006524 NP_062267 Location (UCSC) n/a Chr 7: 26.88 – 26.88 Mb PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Melanoma-derived growth regulatory protein is a protein that in humans is encoded by the MIA gene. ^{[4] [5] [6]}

It is a marker for malignant melanoma. ^[7]

References

1. GRCm38: Ensembl release 89: ENSMUSG00000089661 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Blesch A, Bosserhoff AK, Apfel R, Behl C, Hessdoerfer B, Schmitt A, Jachimczak P, Lottspeich F, Buettner R, Bogdahn U (Nov 1994). "Cloning of a novel malignant melanoma-derived growth-regulatory protein, MIA". Cancer Res. 54 (21): 5695–701. PMID   7923218.
5. Koehler MR, Bosserhoff A, von Beust G, Bauer A, Blesch A, Buettner R, Schlegel J, Bogdahn U, Schmid M (Sep 1996). "Assignment of the human melanoma inhibitory activity gene (MIA) to 19q13.32-q13.33 by fluorescence in situ hybridization (FISH)". Genomics. 35 (1): 265–7. doi:10.1006/geno.1996.0352. PMID   8661134.
6. "Entrez Gene: MIA melanoma inhibitory activity".
7. Bosserhoff AK, Kaufmann M, Kaluza B, et al. (August 1997). "Melanoma-inhibiting activity, a novel serum marker for progression of malignant melanoma". Cancer Res. 57 (15): 3149–53. PMID   9242442.

Further reading

• Bosserhoff AK, Hein R, Bogdahn U, Buettner R (1996). "Structure and promoter analysis of the gene encoding the human melanoma-inhibiting protein MIA". J. Biol. Chem. 271 (1): 490–5. doi: 10.1074/jbc.271.1.490 . PMID   8550608.
• Stoll R, Renner C, Zweckstetter M, et al. (2001). "The extracellular human melanoma inhibitory activity (MIA) protein adopts an SH3 domain-like fold". EMBO J. 20 (3): 340–9. doi:10.1093/emboj/20.3.340. PMC   133488 . PMID   11157741.
• Lougheed JC, Holton JM, Alber T, et al. (2001). "Structure of melanoma inhibitory activity protein, a member of a recently identified family of secreted proteins". Proc. Natl. Acad. Sci. U.S.A. 98 (10): 5515–20. Bibcode:2001PNAS...98.5515L. doi: 10.1073/pnas.091601698 . PMC   33244 . PMID   11331761.
• Lougheed JC, Domaille PJ, Handel TM (2002). "Solution structure and dynamics of melanoma inhibitory activity protein". J. Biomol. NMR. 22 (3): 211–23. doi:10.1023/A:1014961408029. PMID   11991352. S2CID   8265482.
• Hau P, Apfel R, Wiese P, et al. (2002). "Melanoma-inhibiting activity (MIA/CD-RAP) is expressed in a variety of malignant tumors of mainly neuroectodermal origin". Anticancer Res. 22 (2A): 577–83. PMID   12014625.
• Hau P, Wise P, Bosserhoff AK, et al. (2002). "Cloning and characterization of the expression pattern of a novel splice product MIA (splice) of malignant melanoma-derived growth-inhibiting activity (MIA/CD-RAP) [corrected]". J. Invest. Dermatol. 119 (3): 562–9. doi: 10.1046/j.1523-1747.2002.00501.x . PMID   12230496.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Poser I, Golob M, Buettner R, Bosserhoff AK (2003). "Upregulation of HMG1 leads to melanoma inhibitory activity expression in malignant melanoma cells and contributes to their malignancy phenotype". Mol. Cell. Biol. 23 (8): 2991–8. doi:10.1128/MCB.23.8.2991-2998.2003. PMC   152547 . PMID   12665595.
• Callejo SA, Marshall JC, Cools-Lartigue J, et al. (2005). "Macrophage-derived soluble factor enhances melanoma inhibitory activity expression by uveal melanoma cells in vitro". Melanoma Res. 14 (2): 91–5. doi:10.1097/00008390-200404000-00003. PMID   15057037. S2CID   1429873.
• Marr DG, Poser I, Shellman YG, et al. (2005). "Ultraviolet radiation induces release of MIA: a new mechanism for UVR-induced progression of melanoma". Int. J. Oncol. 25 (1): 105–11. doi:10.3892/ijo.25.1.105. PMID   15201995.
• Poser I, Tatzel J, Kuphal S, Bosserhoff AK (2005). "Functional role of MIA in melanocytes and early development of melanoma". Oncogene. 23 (36): 6115–24. doi:10.1038/sj.onc.1207797. PMID   15208686.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC   2286551 . PMID   15340161.
• Jachimczak P, Apfel R, Bosserhoff AK, et al. (2004). "Inhibition of immunosuppressive effects of melanoma-inhibiting activity (MIA) by antisense techniques". Int. J. Cancer. 113 (1): 88–92. doi:10.1002/ijc.20549. PMID   15386421. S2CID   43308803.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Hau P, Ruemmele P, Kunz-Schughart LA, et al. (2005). "Expression levels of melanoma inhibitory activity correlate with time to progression in patients with high-grade glioma". Oncol. Rep. 12 (6): 1355–64. doi:10.3892/or.12.6.1355. PMID   15547763.
• Tatzel J, Poser I, Schroeder J, Bosserhoff AK (2005). "Inhibition of melanoma inhibitory activity (MIA) expression in melanoma cells leads to molecular and phenotypic changes". Pigment Cell Res. 18 (2): 92–101. doi:10.1111/j.1600-0749.2005.00212.x. PMID   15760338.
• Aung PP, Oue N, Mitani Y, et al. (2006). "Systematic search for gastric cancer-specific genes based on SAGE data: melanoma inhibitory activity and matrix metalloproteinase-10 are novel prognostic factors in patients with gastric cancer". Oncogene. 25 (17): 2546–57. doi:10.1038/sj.onc.1209279. PMID   16331256.
• Cao MG, Auge JM, Molina R, et al. (2007). "Melanoma inhibiting activity protein (MIA), beta-2 microglobulin and lactate dehydrogenase (LDH) in metastatic melanoma". Anticancer Res. 27 (1B): 595–9. PMID   17348447.