Mitochondrial ferritin

FTMT
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1R03
Identifiers
Aliases	FTMT , MTF, Mitochondrial ferritin, ferritin mitochondrial
External IDs	OMIM: 608847; MGI: 1914884; HomoloGene: 110661; GeneCards: FTMT; OMA:FTMT - orthologs
Gene location (Human) Chr. Chromosome 5 (human) [1] Band 5q23.1 Start 121,851,882 bp [1] End 121,852,833 bp [1]
Gene location (Mouse) Chr. Chromosome 18 (mouse) [2] Band 18|18 D1 Start 52,464,621 bp [2] End 52,466,068 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad left testis right testis olfactory zone of nasal mucosa human musculoskeletal system skeletal muscle lower limb muscles muscle of leg gastrocnemius muscle subcutaneous adipose tissue Top expressed in seminiferous tubule spermatid spermatocyte pancreas islet of Langerhans More reference expression data BioGPS n/a
Gene ontology Molecular function ferric iron binding metal ion binding oxidoreductase activity iron ion binding ferroxidase activity ferrous iron binding identical protein binding Cellular component nucleus mitochondrion mitochondrial matrix cytoplasm Biological process iron ion transport positive regulation of succinate dehydrogenase activity positive regulation of aconitate hydratase activity positive regulation of cell population proliferation positive regulation of lyase activity intracellular sequestering of iron ion cellular iron ion homeostasis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 94033 67634 Ensembl ENSG00000181867 ENSMUSG00000024510 UniProt Q8N4E7 Q9D5H4 RefSeq (mRNA) NM_177478 NM_026286 RefSeq (protein) NP_803431 NP_080562 Location (UCSC) Chr 5: 121.85 – 121.85 Mb Chr 18: 52.46 – 52.47 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Mitochondrial ferritin is a ferroxidase enzyme that in humans is encoded by the FTMT gene. ^[5]

It is classified as a metal-binding protein which is located within the mitochondria. After the protein is taken up by the mitochondria it can be processed into a mature protein and assemble functional ferritin shells.

Structure

Its structure was determined at 1.70 Å through the use of X-ray diffraction and contains 182 residues. It is 67% helical. The Ramachandran plot shows that the structure of mitochondrial ferritin is mainly alpha helical with a low prevalence of beta sheets.

References

1. GRCh38: Ensembl release 89: ENSG00000181867 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024510 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Levi S, Corsi B, Bosisio M, Invernizzi R, Volz A, Sanford D, Arosio P, Drysdale J (July 2001). "A human mitochondrial ferritin encoded by an intronless gene". J. Biol. Chem. 276 (27): 24437–40. doi: 10.1074/jbc.C100141200 . PMID   11323407.

Further reading

• Langlois d'Estaintot B, Santambrogio P, Granier T, et al. (2004). "Crystal structure and biochemical properties of the human mitochondrial ferritin and its mutant Ser144Ala". J. Mol. Biol. 340 (2): 277–93. doi:10.1016/j.jmb.2004.04.036. PMID   15201052.
• Zanella I, Derosas M, Corrado M, et al. (2008). "The effects of frataxin silencing in HeLa cells are rescued by the expression of human mitochondrial ferritin" (PDF). Biochim. Biophys. Acta. 1782 (2): 90–8. doi:10.1016/j.bbadis.2007.11.006. PMID   18160053.
• Wilkinson J, Di X, Schönig K, et al. (2006). "Tissue-specific expression of ferritin H regulates cellular iron homoeostasis in vivo". Biochem. J. 395 (3): 501–7. doi:10.1042/BJ20060063. PMC   1462685 . PMID   16448386.
• Iwasaki K, Mackenzie EL, Hailemariam K, et al. (2006). "Hemin-mediated regulation of an antioxidant-responsive element of the human ferritin H gene and role of Ref-1 during erythroid differentiation of K562 cells". Mol. Cell. Biol. 26 (7): 2845–56. doi:10.1128/MCB.26.7.2845-2856.2006. PMC   1430308 . PMID   16537925.
• Hasan MR, Tosha T, Theil EC (2008). "Ferritin contains less iron (59Fe) in cells when the protein pores are unfolded by mutation". J. Biol. Chem. 283 (46): 31394–400. doi: 10.1074/jbc.M806025200 . PMC   2581568 . PMID   18805796.
• Cazzola M, Invernizzi R, Bergamaschi G, et al. (2003). "Mitochondrial ferritin expression in erythroid cells from patients with sideroblastic anemia". Blood. 101 (5): 1996–2000. doi: 10.1182/blood-2002-07-2006 . PMID   12406866. S2CID   5729203.
• Faniello MC, Fregola A, Nisticò A, et al. (2006). "Detection and functional analysis of an SNP in the promoter of the human ferritin H gene that modulates the gene expression". Gene. 377: 1–5. doi:10.1016/j.gene.2006.02.034. PMID   16797877.
• Iwasaki K, Hailemariam K, Tsuji Y (2007). "PIAS3 interacts with ATF1 and regulates the human ferritin H gene through an antioxidant-responsive element". J. Biol. Chem. 282 (31): 22335–43. Bibcode:2007JBiCh.28222335I. doi: 10.1074/jbc.M701477200 . PMC   2409283 . PMID   17565989.
• MacKenzie EL, Tsuji Y (2008). "Elevated intracellular calcium increases ferritin H expression through an NFAT-independent post-transcriptional mechanism involving mRNA stabilization". Biochem. J. 411 (1): 107–13. doi:10.1042/BJ20071544. PMC   2702759 . PMID   18076382.
• Drysdale J, Arosio P, Invernizzi R, et al. (2002). "Mitochondrial ferritin: a new player in iron metabolism". Blood Cells Mol. Dis. 29 (3): 376–83. doi:10.1006/bcmd.2002.0577. PMID   12547228.
• Fisher J, Devraj K, Ingram J, et al. (2007). "Ferritin: a novel mechanism for delivery of iron to the brain and other organs". Am. J. Physiol., Cell Physiol. 293 (2): C641–9. doi:10.1152/ajpcell.00599.2006. PMID   17459943. S2CID   2673703.
• Campanella A, Rovelli E, Santambrogio P, et al. (2009). "Mitochondrial ferritin limits oxidative damage regulating mitochondrial iron availability: hypothesis for a protective role in Friedreich ataxia". Hum. Mol. Genet. 18 (1): 1–11. doi:10.1093/hmg/ddn308. PMC   3298861 . PMID   18815198.
• Bou-Abdallah F, Biasiotto G, Arosio P, Chasteen ND (2004). "The putative "nucleation site" in human H-chain ferritin is not required for mineralization of the iron core". Biochemistry. 43 (14): 4332–7. doi:10.1021/bi0498813. PMID   15065877.
• Binning RC, Bacelo DE (2009). "Computational modeling of the dizinc-ferroxidase complex of human H ferritin: direct comparison of the density functional theory calculated and experimental structures". J. Biol. Inorg. Chem. 14 (8) 1199: 1199–208. doi:10.1007/s00775-009-0563-z. PMID   19585161. S2CID   23855417.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• MacKenzie EL, Ray PD, Tsuji Y (2008). "Role and regulation of ferritin H in rotenone-mediated mitochondrial oxidative stress". Free Radic. Biol. Med. 44 (9): 1762–71. doi:10.1016/j.freeradbiomed.2008.01.031. PMC   2682214 . PMID   18325346.
• Bou-Abdallah F, Santambrogio P, Levi S, et al. (2005). "Unique iron binding and oxidation properties of human mitochondrial ferritin: a comparative analysis with Human H-chain ferritin". J. Mol. Biol. 347 (3): 543–54. doi:10.1016/j.jmb.2005.01.007. PMID   15755449.
• Faniello MC, Di Sanzo M, Quaresima B, et al. (2008). "p53-mediated downregulation of H ferritin promoter transcriptional efficiency via NF-Y". Int. J. Biochem. Cell Biol. 40 (10): 2110–9. doi:10.1016/j.biocel.2008.02.010. hdl: 10447/35800 . PMID   18372207.
• Snyder AM, Wang X, Patton SM, et al. (2009). "Mitochondrial ferritin in the substantia nigra in restless legs syndrome". J. Neuropathol. Exp. Neurol. 68 (11): 1193–9. doi:10.1097/NEN.0b013e3181bdc44f. PMC   3024883 . PMID   19816198.