Mugineic-acid 3-dioxygenase

Mugineic-acid 3-dioxygenase
Identifiers
EC no.	1.14.11.25
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Mugineic-acid 3-dioxygenase (EC 1.14.11.25, IDS2) is an enzyme with systematic name mugineic acid,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating). ^{[1] [2]} This enzyme catalyses the following chemical reaction

(1) mugineic acid + 2-oxoglutarate + O₂${\displaystyle \rightleftharpoons }$ 3-epihydroxymugineic acid + succinate + CO₂

(2) 2'-deoxymugineic acid + 2-oxoglutarate + O2 ${\displaystyle \rightleftharpoons }$ 3-epihydroxy-2'-deoxymugineic acid + succinate + CO₂

Mugineic-acid 3-dioxygenase contains iron(II). Mugineic acid is an amino acid excreted by some graminaceous (grassy) plants under conditions of iron deficiency as part of a strategy of solubilizing Fe from the root environment for uptake by the plant. Mugineic acid is closely related to its biochemical precursor, nicotianamine, and to a number of other compounds that also have been identified as phytosiderophores in graminaceous plants: 3-hydroxymugineic acid, 2'-deoxymugineic acid, avenic acid, and distichonic acid. The effectiveness of mugineic acid under iron-deficient conditions is dependent not only upon the iron chelating properties of the Fe-mugineic acid complex itself but also upon the presence of a plant membrane carrier that recognizes and absorbs the Fe-mugineic acid complex almost exclusively. ^[3]

References

1. Nakanishi H, Yamaguchi H, Sasakuma T, Nishizawa NK, Mori S (September 2000). "Two dioxygenase genes, Ids3 and Ids2, from Hordeum vulgare are involved in the biosynthesis of mugineic acid family phytosiderophores". Plant Molecular Biology. 44 (2): 199–207. doi:10.1023/A:1006491521586. PMID   11117263. S2CID   26139505.
2. Okumura N, Nishizawa NK, Umehara Y, Ohata T, Nakanishi H, Yamaguchi T, Chino M, Mori S (July 1994). "A dioxygenase gene (Ids2) expressed under iron deficiency conditions in the roots of Hordeum vulgare". Plant Molecular Biology. 25 (4): 705–19. doi:10.1007/BF00029608. PMID   8061321. S2CID   20143807.
3. "Mugineic acid, a phytosiderophore". Archived from the original on 2011-08-28. Retrieved 2013-11-04.

External links

• Mugineic-acid+3-dioxygenase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)