Interstate 80 (I-80) is an east–west transcontinental freeway that crosses the United States from San Francisco, California, to Teaneck, New Jersey, in the New York metropolitan area. The highway was designated in 1956 as one of the original routes of the Interstate Highway System; its final segment was opened in 1986. The second-longest Interstate Highway in the United States after I-90, it runs through many major cities, including Oakland, Sacramento, Reno, Salt Lake City, Omaha, Des Moines, and Toledo and passes within 10 miles (16 km) of Chicago, Cleveland, and New York City.
U.S. Route 20 or U.S. Highway 20 (US 20) is an east–west United States Numbered Highway that stretches from the Pacific Northwest east to New England. The "0" in its route number indicates that US 20 is a major coast-to-coast route. Spanning 3,365 miles (5,415 km), it is the longest road in the United States, and, in the east, the route is roughly parallel to Interstate 90 (I-90), which is the longest Interstate Highway in the U.S. There is a discontinuity in the official designation of US 20 through Yellowstone National Park, with unnumbered roads used to traverse the park.
U.S. Route 281 (US 281) is a north–south United States Numbered Highway. At 1,875 miles (3,018 km) it is the longest continuous three-digit U.S. Route.
U.S. Route 6 (US 6) or U.S. Highway 6 (US 6), also called the Grand Army of the Republic Highway, honoring the American Civil War veterans association, is a main route of the United States Numbered Highway System. While it currently runs east-northeast from Bishop, California, to Provincetown, Massachusetts, the route has been modified several times. The highway's longest-lasting routing, from 1936 to 1964, had its western terminus at Long Beach, California. During this time, US 6 was the longest highway in the country.
U.S. Route 275 (US 275) is a north–south United States highway that is a branch of US 75. It originally terminated at US 75 in Council Bluffs, Iowa. The highway's northern terminus is in O'Neill, Nebraska, at an intersection with U.S. Highway 20 and U.S. Highway 281. Its southern terminus is near Rock Port, Missouri, at an intersection with U.S. Highway 136.
U.S. Route 34 (US 34) is an east–west United States highway that runs for 1,122 miles (1,806 km) from north-central Colorado to the western suburbs of Chicago. Through Rocky Mountain National Park it is known as the Trail Ridge Road where it reaches an elevation of 12,183 feet (3,713 m), making it one of the highest paved through highways in the United States. The highway's western terminus is Granby, Colorado at US 40. Its eastern terminus is in Berwyn, Illinois at Illinois Route 43 and Historic US 66.
Interstate 76 (I-76) is an east–west Interstate Highway in the Western United States that runs from I-70 in Arvada, Colorado – near Denver – to an interchange with I-80 near Big Springs, Nebraska. The highway measures 187.29 miles (301.41 km) long, mostly situated in Colorado but approximately three miles (4.8 km) of which is in Nebraska. Along the route, the highway runs concurrent with US Route 6 (US 6), US 85 in the Denver metropolitan area, and US 34 from Wiggins to Fort Morgan. It has no auxiliary Interstates, but it has two business routes that are located in northeastern Colorado. This route is not connected with the other I-76 that spans from Ohio to New Jersey.
Iowa Highway 2 is a 251-mile-long (404 km) state highway which runs across the southernmost tier of counties in the U.S. state of Iowa. At no point along its route is Iowa 2 more than 15 miles (24 km) from the Missouri state line, except for a small section near its eastern terminus. Iowa 2 stretches across the entire state; from the Missouri River near Nebraska City, Nebraska, to U.S. Highway 61 (US 61) at Fort Madison. Prior to becoming a primary highway, the route was known as the Waubonsie Trail.
Interstate 680 (I-680) in Nebraska and Iowa is the northern bypass of the Omaha–Council Bluffs metropolitan area. I-680 spans 16.49 miles (26.54 km) from its southern end in western Omaha, Nebraska, to its eastern end near Crescent, Iowa. The freeway passes through a diverse range of scenes and terrains—the urban setting of Omaha, the Missouri River and its valley, the rugged Loess Hills, and the farmland of Pottawattamie County, Iowa.
U.S. Highway 20 (US 20) in Iowa is a major east–west artery which runs across the state, separating the northern third of Iowa from the southern two-thirds. It enters Iowa from Nebraska, concurrent with Interstate 129 (I-129) and US 75, crossing the Missouri River at Sioux City. US 20 runs in a more-or-less straight line across Iowa, paralleling 42° 27' N. It leaves Iowa in Dubuque by crossing the Mississippi River into Illinois. Since October 2018, US 20 is a four-lane divided highway for its entire length in Iowa.
U.S. Highway 30 (US 30) is a major east–west U.S. Highway which spans 330 miles (530 km) across the state of Iowa. It is the longest primary highway in the state and is maintained by the Iowa Department of Transportation. The route in Iowa begins at the Missouri River crossing at Blair, Nebraska, and ends at the Mississippi River crossing at Clinton, Iowa. Along the way, it serves Denison and Carroll in western Iowa, Boone, Ames, and Marshalltown in central Iowa, and Tama, Cedar Rapids, and DeWitt in eastern Iowa. Cutting across the central portion of the state, US 30 runs within close proximity of the Union Pacific Railroad's Overland Route for its entire length.
Nebraska Highway 92 is a highway that enters the state from Nebraska's western border at the Wyoming state line west of Lyman, Nebraska, to the state's eastern border on the South Omaha Veterans Memorial Bridge over the Missouri River in Omaha, where it enters Iowa. Nebraska Highway 92 passes, follows, or runs through a number of the state's principal attractions, including Scotts Bluff National Monument, the Oregon Trail, Chimney Rock National Historic Site, Ash Hollow State Historical Park, Lake McConaughy, the Nebraska Sand Hills, and the City of Omaha. Nebraska Highway 92 is the longest state route in the state at a total of 489.1 miles (787.1 km), and is part of a continuous 886-mile (1,426 km) four-state "Highway 92" which begins in Torrington, Wyoming, goes through Nebraska and Iowa and ends in La Moille, Illinois. It is the only Nebraska Highway to run from the west border to the east border of Nebraska; along the way it crosses the Platte River or its tributary North Platte River a total of five times.
U.S. Highway 6 (US 6) is an east–west United States Numbered Highway which runs 322 miles (518 km) across the U.S. state of Iowa. The route is signed in places as the Grand Army of the Republic Highway. Like all state highways in Iowa, it is maintained by the Iowa Department of Transportation. The route begins at the Missouri River crossing at Council Bluffs. From there, it travels east through Oakland and Atlantic. North of Atlantic, the highway overlaps Interstate 80 (I-80) until De Soto. Between De Soto and Adel, the highway overlaps US 169 before splitting off to the east toward Des Moines. Through the Des Moines area, the highway runs about one mile (1.6 km) north or south of the I-35/I-80 corridor.
U.S. Highway 6 (US-6) in the U.S. state of Nebraska is a United States Numbered Highway which goes from the Colorado border west of Imperial in the west to the Iowa border in the east at Omaha. Significant portions of the highway are concurrent with other highways, most significantly, US-34 between Culbertson and Hastings. Also, from Milford east to the Iowa border, the highway is closely paralleled by Interstate 80 (I-80). Large portions of the route parallel the Chicago, Burlington and Quincy Railroad.
Nebraska Highway 64 is a highway in Nebraska. There are two segments to the highway. The western segment lies in Butler County between U.S. Highway 81 and Nebraska Highway 15. The eastern segment goes through Saunders and Douglas counties between U.S. Highway 77 and U.S. Highway 75.
U.S. Highway 30 (US 30) is part of the United States Numbered Highway System that runs for 3,073 miles (4,946 km) from Astoria, Oregon to Atlantic City, New Jersey. Within the state of Nebraska it is a state highway that travels 451.74 miles (727.01 km) west to east across the state from the Wyoming state line west of Bushnell to the Missouri River in Blair on the Iowa state line. Despite not intersecting I-80 even once, much of its length until Grand Island is closely parallel with the interstate, not being more than a mile or two away. For most of its route, US 30 travels within the Platte River valley, adjacent to or near the river between Brule and Fremont, a distance of just over 300 miles (480 km). This corridor was also highly traveled during Westward Expansion along the California and Oregon Trails, it was also used by the Pony Express and the Transcontinental Railroad. The landscape is dominated by vast agricultural fields within the fertile Platte River valley across the center of the state, while the western portion passes through higher plains and the eastern portion through the rolling hills adjacent to the Missouri River valley.
Nebraska Highway 71 is a highway in western Nebraska. Its southern terminus is at the Colorado border south of Kimball, as a continuation of Colorado State Highway 71. Its northern terminus is at the South Dakota border northwest of Crawford, where it continues as South Dakota Highway 71.
In the U.S. state of Nebraska, U.S. Highway 34 is a highway which goes between the Colorado border west of Haigler to the Iowa border east of Plattsmouth. Between Culbertson and Hastings, U.S. 34 overlaps U.S. Highway 6. From Grand Island to Lincoln, U.S. 34 has been replaced by Interstate 80 as a high-speed corridor and mostly serves local traffic. On this portion of the highway, U.S. 34 is continuously north of Interstate 80. Within Lincoln, U.S. 34 runs concurrent with all of Interstate 180, and much of it follows O Street.
U.S. Route 75 was a part of the United States Numbered Highway System that runs for 1,239 miles (1,994 km) from Dallas, Texas to Kittson County, Minnesota where it ends just short of the Canada–United States border. Within the State of Nebraska it is a state highway that enters Nebraska on the Kansas state line about 9 miles (14 km) south of Dawson and travels north across the extreme eastern portion of the state, to the Nebraska–Iowa border in South Sioux City where it crosses the Missouri River along a concurrency with Interstate 129. The northern 210 miles (340 km) of the route generally travels parallel to the Missouri River. The 87.32-mile (140.53 km) section between the I-680 interchange in Omaha and the Interstate 129 interchange is designated the Lewis & Clark Scenic Byway, one of nine scenic byways in the state.
Several special routes of U.S. Route 30 exist. In order from west to east they are as follows.
N-71 / SD 71 north of Crawford 
I-80 southeast of Grand Island
US 77 south of Lincoln 
Iowa 2 at Missouri River in Nebraska City 
