Organ procurement

Last updated
Organ harvesting
MeSH D020858

Organ procurement (also called surgical recovery) is a surgical procedure that removes organs or tissues for reuse, typically for organ transplantation. [1]

Contents

Procedures

If the organ donor is human, most countries require that the donor be legally dead for consideration of organ transplantation (e.g. cardiac death or brain death). For some organs, a living donor can be the source of the organ. For example, living donors can donate one kidney or part of their liver to a well-matched recipient. [2]

Organs cannot be procured after the heart has stopped beating for a long time. Thus, donation after brain death is generally preferred because the organs are still receiving blood from the donor's heart until minutes before being removed from the body and placed on ice. In order to better standardize the evaluation of brain death, The American Academy of Neurology (AAN) published a new set of guidelines in 2010. These guidelines require that three clinical criteria be met in order to establish brain death: coma with a known cause, absence of brain stem reflexes, and apnea. [3]

Donation after cardiac death (DCD) involves surgeons taking organs within minutes of the cessation of respirators and other forms of life support for patients who still have at least some brain activity. This occurs in situations where, based on the patient's advanced directive or the family's wishes, the patient is going to be withdrawn from life support. After this decision has been made, the family is contacted for consideration for organ donation. Once life support has been withdrawn, there is a 2-5 minute waiting period to ensure that the potential donor's heart does not start beating again spontaneously. [4] After this waiting period, the organ procurement surgery begins as quickly as possible to minimize time that the organs are not being perfused with blood. DCD had been the norm for organ donors until 'brain death' became a legal definition in the United States in 1981. [5] Since then, most donors have been brain-dead. [6]

If consent is obtained from the potential donor or the potential donor's survivors, the next step is to perform a match between the source (donor) and the target (recipient) to reduce rejection of the organ by the recipient's immune system. In the United States, the match between human donors and recipients is coordinated by groups like United Network for Organ Sharing. [7]

Co-ordination between teams working on different organs is often necessary in case of multiple-organ procurement. [8] Multiple-organ procurement models are also developed from slaughtered pigs to reduce the use of laboratory animals. [9]

The quality of the organ then is certified. If the heart stopped beating for too long then the organ becomes unusable [8] and cannot be used for transplant.

Preservation and transport

After organ procurement, the organs are often rushed to the site of the recipient for transplantation or preserved for later study. The faster the organ is transplanted into the recipient, the better the outcome. While the organ is being transported, it is either stored in an icy cold solution to help preserve it or it is connected to a miniature organ perfusion system which pumps an icy solution (sometimes enriched with potassium) through the organ. [5] [10] [11] [12] This time during transport is called the "cold ischemia time". Heart and lungs should have less than 6 hours between organ procurement and transplantation. [13] For liver transplants, the cold ischemia time can be up to 24 hours, [13] although typically surgeons aim for a much shorter period of time. For kidney transplants, as the cold ischemia time increases, the risk of delayed function of the kidney increases. [5] Sometimes, the kidney function is delayed enough that the recipient requires temporary dialysis until the transplanted kidney begins to function. [14]

In recent years novel methods of organ preservation have emerged that may be able to improve the quality of donated organs or assess their viability. In the case of DCD, the first technique established for organ procurement was super-rapid recovery. [15] The most widely used technique involves machine perfusion of the organ at either hypothermic (4-10 °C) or normothermic (37 °C) temperatures. Hypothermic perfusion of kidneys is a relatively widespread practice. For the heart normothermic preservation has been used in which the heart is provided with warm oxygenated blood and so continues to beat ex-vivo during its preservation. This technique has also been applied to lungs and led to the emergence of donor lung reconditioning centres in North America. For the liver, hypothermic and normothermic techniques are being used with evidence to suggest that both may be beneficial. [16]

There is ongoing research and development to improve machine perfusion and alternative approaches such as novel cryoprotectant solvents to improve organ viability and availability – such as by increasing preservation durations. [17] [18]

Ethical issues

According to the World Health Organization (WHO), illegal organ trade occurs when organs are removed from the body for the purpose of commercial transactions. [19] Despite ordinances against organ sales, this practice persists, with studies estimating that anywhere from 5% to 42% of transplanted organs are illicitly purchased. [20] [21] [22] Research indicates that illegal organ trade is on the rise, with a recent report by Global Financial Integrity estimating that the illegal organ trade generates profits between $600 million and $1.2 billion per year, with a span over many countries. These countries include, but are not limited to:

Although the procedure of organ transplantation has become widely accepted, there are still a number of ethical debates around related issues. The debates center around illegal, forced or compensated transplantation like organ theft or organ trade, fair organ distribution, and to a lesser degree, animal rights and religious prohibition on consuming some animals such as pork.

There is a shortage of organs available for donation with many patients waiting on the transplant list for a donation match. About 20 patients die each day waiting for an organ on the transplant list. [43] When an organ donor does arise, the transplant governing bodies must determine who receives the organ. The UNOS computer matching system finds a match for the organ based on a number of factors including blood type and other immune factors, size of the organ, medical urgency of the recipient, distance between donor and recipient, and time the recipient has been waiting on the waitlist. [13]

Because of the significant need for organs for transplantation, there is ethical debate around where the organs can be obtained from and whether some organs are obtained illegally or through coercion.

In 2009, the Swedish tabloid Aftonbladet triggered international controversy by claiming that Israeli troops killed Palestinians in order to harvest their organs – the Israeli government condemned the allegations as an antisemitic libel. [44] During the controversy, it emerged that there had been a practice in Israel of harvesting tissues from the deceased (both Israelis, Palestinians, and foreigners) without the knowledge and consent of their families, but that practice ended in the 1990s. [45]

China

In 2005, China admitted to using the organs of executed prisoners for transplant. [46] Due to religious tradition of many Chinese people who value leaving the body whole after death, the availability of organs for transplant is much more limited. Almost all the organs transplanted from deceased donors came from executed prisoners. [46] Since then, China has repeatedly been found to have a rampant black market for organs for transplant, including continued use of organs from executed prisoners without their consent and targeting young army conscripts for their organs. [47] In 2014, China promised that by January 1, 2015, only voluntary organ donors would be accepted. [48] China has worked to increase the number of voluntary organ donors as well as to convince the international community that they have changed their organ procurement practices after many prior failed attempts to do so. [49] According to the former vice-minister of health, Dr. Huang Jiefu, the number of voluntary organ transplants increased by 50% from 2015 to 2016. [49] Many of the organs harvested are sold to overseas buyers who fly to China for the transplantation procedure. It is possible to schedule these surgeries in advance which is not possible in systems which rely on voluntary organ donation. [50] In the year 2020, allegations were made that Muslim customers from the Middle East, including Saudi Arabia, reportedly request Halal organs, those which come from a Muslim person from Xinjiang. [51]

In August 2024, media outlets reported on the first known survivor of China’s forced organ harvesting. [52] [53] The Diplomat reported its interview with Cheng Pei Ming, a Falun Gong practitioner, who recounted how he was subjected to repeated blood tests and a subsequent forced surgery while imprisoned in China and later discovered during medical exams in the U.S. that segments of his liver and a portion of his lung had been surgically removed. [52]

India

Before 1994, India had no legislation banning the sale of organs. [54] Low costs and high availability brought in business from around the globe, and transformed India into one of the largest kidney transplant centers in the world. [55] However, several problems began to surface. Patients were often promised payments that were much higher than what they actually received. [56] Other patients reported that their kidneys were removed without their consent after they underwent procedures for other reasons. [57]

In 1994, the country passed the Transplantation of Human Organs Act (THOA), banning commerce in organs and promoting posthumous donation of organs. [58] The law's primary mechanism for preventing the sale of organs was to restrict who could donate a kidney to another person. In particular, the THOA bars strangers from donating to one another; a person can only donate to a relative, spouse, or someone bound by "affection." In practice, though, people evade the law's restrictions to continue the trade in organs. Often, claims of "affection" are unfounded and the organ donor has no connection to the recipient. [59] In many cases, the donor may not be Indian or even speak the same language as the recipient. [60] There have also been reports of the donor marrying the recipient to circumvent THOA's prohibition. [61]

Israel

The Aftonbladet–Israel controversy refers to the controversy that followed the publication of a 17 August 2009 article in the Swedish tabloid Aftonbladet , one of the largest daily newspapers in the Nordic countries. The article alleged that Israeli troops harvested organs from Palestinians who had died in their custody. Sparking a fierce debate in Sweden and abroad, the article created a rift between the Swedish and the Israeli governments. [62] [63] Israeli officials denounced the report at the time and labelled it anti-Semitic. Written by Swedish freelance [63] photojournalist Donald Boström, the article's title was Våra söner plundras på sina organ ("Our sons are being plundered for their organs"). It presented allegations that in the late 1980s and the early 1990s, many young men from the West Bank and Gaza Strip had been seized by Israeli forces and their bodies returned to their families with organs missing.[ citation needed ]

The Israeli government and several US representatives [64] [65] condemned the article as baseless and incendiary, noted the history of antisemitism and blood libels against Jews and asked the Swedish government to denounce the article. The government refused, citing freedom of the press and the Swedish constitution. Swedish ambassador to Israel Elisabet Borsiin Bonnier condemned the article as "shocking and appalling" and stated that freedom of the press carries responsibility, but the Swedish government distanced itself from her remarks. [66] The Swedish Newspaper Publishers' Association and Reporters Without Borders supported Sweden's refusal to condemn it. The former warned of venturing onto a slope with government officials damning occurrences in Swedish media, which may curb warranted debate and restrain freedom of expression by self-censorship. [67] Italy made a stillborn attempt to defuse the diplomatic situation by a European resolution condemning antisemitism. [68] The Palestinian National Authority announced that it would establish a commission to investigate the article's claims. [69] [70] A survey among the cultural editors of the other major Swedish newspapers found that all would have refused the article. [71]

In December 2009, a 2000 interview with the chief pathologist at the L. Greenberg National Institute of Forensic Medicine Yehuda Hiss was released in which he had admitted taking organs from the corpses of Israeli soldiers, Israeli citizens, Palestinians and foreign workers without their families' permission. Israeli health officials confirmed Hiss's confession but stated that such incidents had ended in the 1990s and noted that Hiss had been removed from his post. [72] [73] [74]

The Palestinian press claimed the report "appeared to confirm Palestinians' allegations that Israel returned their relatives' bodies with their chests sewn up, having harvested their organs". [75]

Several news agencies reported that the Aftonbladet article had claimed that Israel killed Palestinians to harvest their organs, [76] although the author, the culture editor for Aftonbladet, and Nancy Scheper-Hughes denied that it had made that claim.

The Philippines

Although the sale of organs was not legal in the Philippines, prior to 2008 the practice was tolerated and even endorsed by the government. [77] The Philippine Information Agency, a branch of the government, even promoted "all-inclusive" kidney transplant packages that retailed for roughly $25,000. The donors themselves often received as little as $2,000 for their kidneys. [77] The country was a popular destination for transplant tourism. One high-ranking government official estimated that 800 kidneys were sold annually in the country prior to 2008, [78] and the WHO listed it as one of the top 5 sites for transplant tourists in 2005. [41]

In March 2008, the government passed new legislation enforcing a ban on organ sales. After the crackdown on the practice, the number of transplants has decreased from 1,046 in 2007 to 511 in 2010. [79] Since then, the government has taken a much more active stance against transplant tourism.[ citation needed ]

In the United States

In the United States, organ procurement is heavily regulated by United Network for Organ Sharing (UNOS) to prevent unethical allocation of organs. [5] There are over 110,000 patients on the national waiting list for organ transplantation and in 2016, only about 33,000 organ transplants were performed. [43] Due to the lack of organ availability, about 20 patients die each day on the waiting list for organs. [43] Organ transplantation and allocation is mired in ethical debate because of this limited availability of organs for transplant. In the United States in 2016, there were 19,057 kidney transplants, 7,841 liver transplants, 3,191 heart transplants, and 2,327 lung transplants performed. [80]

Regulation

Organ procurement is tightly regulated by United Network for Organ Sharing (UNOS). In the United States, there are a total of 58 Organ Procurement Organizations (OPOs) that are responsible for evaluating the candidacy of deceased donors for organ donation as well as coordinating the procurement of the organs. [5] Each OPO is responsible for a particular geographic region and is under the regulation of the Organ Procurement and Transplantation Network.

Geographic Transplant Regions

The United States is divided into 11 geographic regions by the Organ Procurement and Transplantation Network. [81] Between these regions, there are significant differences in wait time for patients on the organ transplant list. This is of particular concern for liver transplant patients because transplantation is the only cure to end-stage liver disease and without a transplant, these patients will die. [82] One example that brought this disparity to light was in 2009, when Steve Jobs traveled from California, where wait times are known to be very long, to Tennessee, where wait times are much shorter, to increase his chances of getting a liver transplant. [81] In 2009, when Jobs received his liver transplant, the average wait time for liver transplantation in the United States for a patient with a MELD score of 38 (a metric of severity of liver disease) was about 1 year. In some regions, the wait time was as short as 4 months, while in others, it was more than 3 years. [83] This variation for a patient with the same illness severity has caused significant controversy over how organs are distributed.

HOPE Act

The HOPE (HIV Organ Policy Equity) Act allows for clinical research on organ transplantation from HIV+ donors to HIV+ recipients. The Act was passed by Congress in 2013 and officially changed OPTN policy to allow for its implementation in November, 2015. [84] Prior to the HOPE Act, it was banned to acquire organs from any potential donor who was known to have, or even suspected to have, HIV. [85] According to UNOS, in the first year of implementation, 19 organs were transplanted under the HOPE Act. [86] Thirteen of those organs transplanted were kidneys and 6 were livers. [86]

See also

Related Research Articles

<span class="mw-page-title-main">Organ donation</span> Process of voluntarily giving away organs

Organ donation is the process when a person authorizes an organ of their own to be removed and transplanted to another person, legally, either by consent while the donor is alive, through a legal authorization for deceased donation made prior to death, or for deceased donations through the authorization by the legal next of kin.

<span class="mw-page-title-main">Organ transplantation</span> Medical procedure in which an organ is removed from one body and placed in the body of a recipient

Organ transplantation is a medical procedure in which an organ is removed from one body and placed in the body of a recipient, to replace a damaged or missing organ. The donor and recipient may be at the same location, or organs may be transported from a donor site to another location. Organs and/or tissues that are transplanted within the same person's body are called autografts. Transplants that are recently performed between two subjects of the same species are called allografts. Allografts can either be from a living or cadaveric source.

<span class="mw-page-title-main">Liver transplantation</span> Type of organ transplantation

Liver transplantation or hepatic transplantation is the replacement of a diseased liver with the healthy liver from another person (allograft). Liver transplantation is a treatment option for end-stage liver disease and acute liver failure, although availability of donor organs is a major limitation. Liver transplantation is highly regulated, and only performed at designated transplant medical centers by highly trained transplant physicians. Favorable outcomes require careful screening for eligible recipients, as well as a well-calibrated live or deceased donor match.

<span class="mw-page-title-main">Kidney transplantation</span> Medical procedure

Kidney transplant or renal transplant is the organ transplant of a kidney into a patient with end-stage kidney disease (ESRD). Kidney transplant is typically classified as deceased-donor or living-donor transplantation depending on the source of the donor organ. Living-donor kidney transplants are further characterized as genetically related (living-related) or non-related (living-unrelated) transplants, depending on whether a biological relationship exists between the donor and recipient. The first successful kidney transplant was performed in 1954 by a team including Joseph Murray, the recipient's surgeon, and Hartwell Harrison, surgeon for the donor. Murray was awarded a Nobel Prize in Physiology or Medicine in 1990 for this and other work. In 2018, an estimated 95,479 kidney transplants were performed worldwide, 36% of which came from living donors.

<span class="mw-page-title-main">United Network for Organ Sharing</span>

The United Network for Organ Sharing (UNOS) is a non-profit scientific and educational organization that administers the only Organ Procurement and Transplantation Network (OPTN) in the United States, established by the U.S. Congress in 1984 by Gene A. Pierce, founder of United Network for Organ Sharing. Located in Richmond, Virginia, the organization's headquarters are situated near the intersection of Interstate 95 and Interstate 64 in the Virginia BioTechnology Research Park.

<span class="mw-page-title-main">Organ transplantation in China</span>

Organ transplantation in China has taken place since the 1960s, and is one of the largest organ transplant programmes in the world, peaking at over 13,000 liver and kidney transplants a year in 2004.

<span class="mw-page-title-main">National Organ Transplant Act of 1984</span> American legislation

The National Organ Transplant Act (NOTA) of 1984 is an Act of the United States Congress that created the framework for the organ transplant system in the country. The act provided clarity on the property rights of human organs obtained from deceased individuals and established a public-private partnership known as Organ Procurement and Transplantation Network (OPTN). The OPTN was given the authority to oversee the national distribution of organs.

Organ trade is the trading of human organs, tissues, or other body products, usually for transplantation. According to the World Health Organization (WHO), organ trade is a commercial transplantation where there is a profit, or transplantations that occur outside of national medical systems. There is a global need or demand for healthy body parts for transplantation, which exceeds the numbers available.

Organ transplantation in Israel has historically been low compared to other Western countries due to a common belief that organ donation is prohibited under Jewish law. This changed with the passage of new organ donation laws in 2008. If two patients have the same medical need, priority will now go to the patient who has signed an organ donor card, or whose family members have donated an organ. This policy was nicknamed don't give, don't get. The law also defines "brain death" as an indication of death for all legal purposes, including organ donation. Additionally the law provides financial reimbursement to living donors for medical expenses due to donation and lost time at work. Organ trafficking is explicitly banned. Health insurance plans can no longer reimburse patients who go abroad to receive transplants.

Organ theft is the act of taking a person's organs for transplantation or sale on the black market, without their explicit consent through means of being an organ donor or other forms of consent. Most cases of organ theft involve coercion, occurrences in wartime, or thefts within hospital settings. Organ theft is a commonly used trope in speculative fiction.

<span class="mw-page-title-main">Francis L. Delmonico</span> American transplant surgeon

Francis L. Delmonico, MD, FACS is an American surgeon, clinical professor and health expert in the field of transplantation. He serves on numerous committees and is affiliated with various leading organizations and institutions. He is the chief medical officer of the New England Organ Bank (NEOB) and Professor of Surgery, Part-Time at Harvard Medical School in Boston, Massachusetts, where he is emeritus director of renal transplantation. He served as president of The Transplantation Society (TTS) from 2012 to 2014, an international non-profit organization based in Montreal, Canada that works with international transplantation physicians and researchers. He also served as the president of the United Network of Organ Sharing (UNOS) in 2005, which overseas the practice of organ donation and transplantation in the United States. He was appointed and still serves as an advisor to the World Health Organization in matters of organ donation and transplantation. He was appointed by Pope Francis to the Pontifical Academy of Science in 2016. In 2020, he became the recipient of the Medawar Prize of The Transplantation Society.

<span class="mw-page-title-main">Kidney trade in Iran</span> Legal and government-regulated practice in Iran

The practice of selling one's kidney for profit in Iran is legal and regulated by the government. In any given year, it is estimated that 1400 Iranians sell one of their kidneys to a recipient who was previously unknown to them. Iran currently is the only country in the world that allows the sale of one's kidney for compensation ; consequently, the country does not have either a waiting list or a shortage of available organs.

In bioethics, ethics of organ transplantation refers to the ethical concerns on organ transplantation procedures. Both the source and method of obtaining the organ to transplant are major ethical issues to consider, as well as the notion of distributive justice.

ABO-incompatible (ABOi) transplantation is a method of allocation in organ transplantation that permits more efficient use of available organs regardless of ABO blood type, which would otherwise be unavailable due to hyperacute rejection. Primarily in use in infants and young toddlers, research is ongoing to allow for increased use of this capability in adult transplants. Normal ABO-compatibility rules may be observed for all recipients. This means that anyone may receive a transplant of a type-O organ, and consequently, type-O recipients are one of the biggest beneficiaries of ABO-incompatible transplants. While focus has been on infant heart transplants, the principles generally apply to other forms of solid organ transplantation.

Allegations of forced organ harvesting from Falun Gong practitioners and other political prisoners in China have raised concern within the international community. According to a report by former lawmaker David Kilgour, human rights lawyer David Matas, and journalist Ethan Gutmann of the US government-affiliated Victims of Communism Memorial Foundation, political prisoners, mainly Falun Gong practitioners, are being executed "on-demand" in order to provide organs for transplant to recipients. Reports have said that organ harvesting has been used to advance the Chinese Communist Party's persecution of Falun Gong and because of the financial incentives available to the institutions and individuals involved in the trade. A report by The Washington Post has disputed some of the allegations, saying that China does not import sufficient quantities of immunosuppressant drugs, used by transplant recipients, to carry out such quantities of organ harvesting. However, the Victims of Communism Memorial Foundation alleged that the Post's article made an “elementary statistical error” and omitted unofficial pharmacy data in Chinese hospitals.

Organ donation is when a person gives their organs after they die to someone in need of new organs. Transplantation is the process of transplanting the organs donated into another person. This process extends the life expectancy of a person suffering from organ failure. The number of patients requiring organ transplants outweighs the number of donor organs available.

Kidney paired donation (KPD), or paired exchange, is an approach to living donor kidney transplantation where patients with incompatible donors swap kidneys to receive a compatible kidney. KPD is used in situations where a potential donor is incompatible. Because better donor HLA and age matching are correlated with lower lifetime mortality and longer lasting kidney transplants, many compatible pairs are also participating in swaps to find better matched kidneys. In the United States, the National Kidney Registry organizes the majority of U.S. KPD transplants, including the largest swaps. The first large swap was a 60 participant chain in 2012 that appeared on the front page of the New York Times and the second, even larger swap, included 70 participants and was completed in 2014. Other KPD programs in the U.S. include the UNOS program, which was launched in 2010 and completed its 100th KPD transplant in 2014, and the Alliance for Paired Donation.

Human organ trafficking in Egypt, as of 2014 mainly practiced in Cairo and the Sinai Peninsula, includes organ harvesting with induced consent, coercion, and outright theft. Egypt has become the largest hub of organ transplant in North Africa as one of the few countries that prohibited organ donation from deceased donors until 2010, with over 500 kidney transplant operations a year and the majority of these organs come from living donors. Sources in the organ trafficking process mainly come from vulnerable populations including domestic rural migrants, undocumented asylum seekers and informal labor. The emergence of cultural and religious increase in organ trade and transplant tourism contribute to the rocketing demand for organ trafficking market in Egypt. Human organ trafficking poses both physical and mental health consequences for victims. Although Egypt has been gradually updating legal frameworks to combat organ trafficking, the regulation has failed in reality protecting survivors and governing transplant professionals.

Organ donation in India is regulated by the Transplantation of Human Organs and Tissues Act, 1994. The law allows both deceased and living donors to donate their organs. It also identifies brain death as a form of death. The National Organ and Tissue Transplant Organisation (NOTTO) functions as the apex body for activities of relating to procurement, allotment and distribution of organs in the country.

Nancy L. Ascher is an American surgeon, and the first woman to perform a liver transplant. Ascher specializes in transplant surgery, focusing on end-stage kidney disease, kidney transplantation, non-alcoholic fatty liver disease and liver transplantation.

References

  1. ↑ "Tissue and Organ Harvesting" . Retrieved 2014-01-11.
  2. ↑ "Living Organ Donation | organdonor.gov". www.organdonor.gov. Retrieved 2023-11-15.
  3. ↑ Principles of critical care. Hall, Jesse B.,, Schmidt, Gregory A.,, Kress, John P. (Fourth ed.). New York. 2015-06-02. ISBN   978-0071738811. OCLC   906700899.{{cite book}}: CS1 maint: location missing publisher (link) CS1 maint: others (link)
  4. ↑ Sade, Robert M. (August 2011). "Brain death, cardiac death, and the dead donor rule". Journal of the South Carolina Medical Association (1975). 107 (4): 146–149. ISSN   0038-3139. PMC   3372912 . PMID   22057747.
  5. 1 2 3 4 5 Schwartz's principles of surgery. Schwartz, Seymour I., 1928-, Brunicardi, F. Charles,, Andersen, Dana K.,, Billiar, Timothy R.,, Dunn, David L.,, Hunter, John G. (Tenth ed.). [New York]. 2014-07-16. ISBN   978-0071796750. OCLC   892490454.{{cite book}}: CS1 maint: location missing publisher (link) CS1 maint: others (link)
  6. ↑ Sade, Robert M. (2017-01-31). "Brain death, cardiac death, and the dead donor rule". Journal of the South Carolina Medical Association (1975). 107 (4): 146–149. ISSN   0038-3139. PMC   3372912 . PMID   22057747.
  7. ↑ Steinbrook, Robert (2007). "Organ Donation after Cardiac Death". New England Journal of Medicine. 357 (3): 209–213. doi:10.1056/NEJMp078066. PMID   17634455.
  8. 1 2 An improved technique for multiple organ harvesting, TE Starzl, C Miller, B Broznick, Surg Gynecol Obstet. 1987 October; 165(4): 343–348.
  9. ↑ Multiple-organ harvesting for models of isolated hemoperfused organs of slaughtered pigs. C Grosse-Siestrup, C Fehrenberg, H von Baeyer. Dept. and Facilities of Experimental Animal Sciences, Humboldt University of Berlin, Germany
  10. ↑ Organ transport methods
  11. ↑ "First clinical heart transplant performed using Stig Steen's new method". News Powered by Cision. 12 September 2017.
  12. ↑ Kimblad, Per Ola; Sjöberg, Trygve; Massa, Giorgio; Solem, Jan-Otto; Steen, Stig (1991). "High potassium contents in organ preservation solutions cause strong pulmonary vasocontraction". The Annals of Thoracic Surgery. 52 (3): 523–528. doi: 10.1016/0003-4975(91)90917-F . PMID   1898141.
  13. 1 2 3 "Learn about the Donor Matching System - OPTN". optn.transplant.hrsa.gov. Retrieved 2017-12-03.
  14. ↑ Lager, Donna J. (2013-01-01), Lager, Donna J.; Abrahams, Neil A. (eds.), "9 - Pathology of Kidney Transplantation", Practical Renal Pathology, Philadelphia: W.B. Saunders, pp. 183–202, doi:10.1016/b978-0-443-06966-6.00011-8, ISBN   978-0-443-06966-6 , retrieved 2023-11-16
  15. ↑ Cascales-Campos, Pedro A.; Ferreras, David; Alconchel, Felipe; Febrero, Beatriz; Royo-Villanova, Mario; Martínez, María; Rodríguez, José M.; Fernández-Hernández, Juan Á; Ríos, Antonio; Pons, José A.; Sánchez-Bueno, Francisco (January 2020). "Controlled donation after circulatory death up to 80 years for liver transplantation: Pushing the limit again". American Journal of Transplantation. 20 (1): 204–212. doi: 10.1111/ajt.15537 . ISSN   1600-6143. PMID   31329359. S2CID   198136656.
  16. ↑ Nasralla, David; Coussios, Constantin C.; Mergental, Hynek; Akhtar, M. Zeeshan; Butler, Andrew J.; Ceresa, Carlo D. L.; Chiocchia, Virginia; Dutton, Susan J.; García-Valdecasas, Juan Carlos; Heaton, Nigel; Imber, Charles; Jassem, Wayel; Jochmans, Ina; Karani, John; Knight, Simon R.; Kocabayoglu, Peri; Malagò, Massimo; Mirza, Darius; Morris, Peter J.; Pallan, Arvind; Paul, Andreas; Pavel, Mihai; Perera, M. Thamara P. R.; Pirenne, Jacques; Ravikumar, Reena; Russell, Leslie; Upponi, Sara; Watson, Chris J. E.; Weissenbacher, Annemarie; et al. (2018). "A randomized trial of normothermic preservation in liver transplantation". Nature. 557 (7703): 50–56. Bibcode:2018Natur.557...50N. doi:10.1038/s41586-018-0047-9. PMID   29670285. S2CID   4990879.
  17. ↑ Clavien, Pierre-Alain; Dutkowski, Philipp; Mueller, Matteo; Eshmuminov, Dilmurodjon; Bautista Borrego, Lucia; Weber, Achim; Muellhaupt, Beat; Sousa Da Silva, Richard X.; Burg, Brian R.; Rudolf von Rohr, Philipp; Schuler, Martin J.; Becker, Dustin; Hefti, Max; Tibbitt, Mark W. (31 May 2022). "Transplantation of a human liver following 3 days of ex situ normothermic preservation". Nature Biotechnology. 40 (11): 1610–1616. doi:10.1038/s41587-022-01354-7. ISSN   1546-1696. PMID   35641829. S2CID   249234907.
  18. ↑ Bryant, Saffron J.; Awad, Miyah N.; Elbourne, Aaron; Christofferson, Andrew J.; Martin, Andrew V.; Meftahi, Nastaran; Drummond, Calum J.; Greaves, Tamar L.; Bryant, Gary (22 June 2022). "Deep eutectic solvents as cryoprotective agents for mammalian cells". Journal of Materials Chemistry B. 10 (24): 4546–4560. doi:10.1039/D2TB00573E. ISSN   2050-7518. PMID   35670530.
  19. ↑ Jafar, Tazeen H. (2009). "Organ Trafficking: Global Solutions for a Global Problem". American Journal of Kidney Diseases . 54 (6): 1145–57. doi: 10.1053/j.ajkd.2009.08.014 . PMID   19880230.
  20. ↑ Shimazono, Yosuke (2007). "The State of the International Organ Trade: A Provisional Picture Based on Integration of Available Information". Bulletin of the World Health Organization. 85 (12): 955–62. doi:10.2471/blt.06.039370 (inactive 5 December 2024). PMC   2636295 . PMID   18278256. Archived from the original on December 20, 2007.{{cite journal}}: CS1 maint: DOI inactive as of December 2024 (link)
  21. ↑ Delmonico, Francis L. (2009). "The Implications of Istanbul Declaration on organ trafficking and transplant tourism". Current Opinion in Organ Transplantation. 14 (2): 116–19. doi:10.1097/MOT.0b013e32832917c9. PMID   19300258. S2CID   205837499.
  22. ↑ Meyer, Silke (2006). "Trafficking in Human Organs in Europe: A Myth or an Actual Threat?". European Journal of Crime, Criminal Law and Criminal Justice. 14 (2): 208–29. doi:10.1163/157181706777978739.
  23. 1 2 3 4 Edward Fox (2012-07-19). "Desperation, Lack of Donors Drives Organ Trafficking in Latin America" . Retrieved 12 November 2015.
  24. ↑ "Brazilian doctors convicted over organ trafficking". 9 February 2014. Retrieved 12 November 2015.
  25. 1 2 "Organ Trafficking Is No Myth". newsweek.com. 9 January 2009.
  26. ↑ Ambagtsheer, F.; Weimar, W. (2011). "A Criminological Perspective: Why Prohibition of Organ Trade Is Not Effective and How the Declaration of Istanbul Can Move Forward". American Journal of Transplantation . 12 (3): 571–75. doi: 10.1111/j.1600-6143.2011.03864.x . PMID   22150956.
  27. ↑ Fan, Jiayang (10 January 2014). "Can China Stop Organ Trafficking?". The New Yorker.
  28. ↑ "CHINA FACES ENORMOUS CHALLENGES IN ENDING ORGAN TRAFFICKING". The Laogai Research Foundation. 13 January 2014.
  29. ↑ "Murder for Organs Broker China Considers Financial Incentives for Donation". First Things. 3 May 2011. Retrieved 12 November 2015.
  30. ↑ "Roger Lee Mendoza (2012). Transplant management from a vendor's perspective. Journal of Health Management, 14, 1 (March 2012): 67–74".
  31. ↑ Mendoza, Roger Lee (2010). "Colombia's organ trade: Evidence from Bogotá and Medellín". Journal of Public Health. 18 (4): 375–84. doi:10.1007/s10389-010-0320-3. ISSN   0943-1853. S2CID   35056299.
  32. ↑ "Four Arrested in Costa Rica For Organ Trafficking". insightcrime.org. 11 October 2013.
  33. ↑ "Georgia teen was stuffed with newspaper after death, family lawyer says - NBC News". www.nbcnews.com. Archived from the original on 2014-02-05.
  34. ↑ "Traffickers targeting Haiti's children, human organs, PM says - CNN.com". www.cnn.com. Retrieved 2019-02-18.
  35. ↑ "Israel Became Hub in International Organ Trade Over Past Decade". Haaretz. 2018-09-20. Retrieved 20 September 2018.
  36. ↑ "Kidney traffickers selling organs to Israelis go on trial in Costa Rica". The Times of Israel . Retrieved 11 September 2017.
  37. ↑ Read more in the article Organ theft in Kosovo.
  38. ↑ "Israeli organ-smuggling 'mastermind' arrested in Cyprus". The Times of Israel . 9 January 2009.
  39. ↑ "Lawyer: Slaves In Libya Are Used For Organ Trade". huffingtonpost.co.za. 3 December 2017. Archived from the original on 13 December 2017. Retrieved 4 April 2021.
  40. ↑ "Mexico cartel member held in organ theft case" . Retrieved 12 November 2015.
  41. 1 2 Lee Mendoza Roger (2010). "Kidney black markets and legal transplants: Are they opposite sides of the same coin?". Health Policy. 94 (3): 255–65. doi:10.1016/j.healthpol.2009.10.005. PMID   19931205. S2CID   35121955.
  42. ↑ "philippines illegal organ trade – Google zoeken" . Retrieved 12 November 2015.
  43. 1 2 3 "Organ Donation Statistics: Why be an Organ Donor? | organdonor.gov". www.organdonor.gov. Retrieved 2017-12-06.
  44. ↑ Boudreaux, Richard (2009-08-24). "Article about organ harvesting sparks Israel-Sweden tiff". Los Angeles Times. Retrieved 2020-05-29.
  45. ↑ Black, Ian (2009-12-21). "Doctor admits Israeli pathologists harvested organs without consent". The Guardian. ISSN   0261-3077 . Retrieved 2020-05-30.
  46. 1 2 "China To 'Tidy Up' Trade in Executed Prisoners' Organs". The Times. December 3, 2005.
  47. ↑ Foster, Peter (2009-08-26). "China admits organs removed from prisoners for transplants". Daily Telegraph. ISSN   0307-1235 . Retrieved 2017-12-07.
  48. ↑ "China to end prisoners organ harvest". BBC News. 2014-12-04. Retrieved 2017-12-07.
  49. 1 2 "We're not harvesting dead prisoners' organs any more, China insists". South China Morning Post. Retrieved 2017-12-07.
  50. ↑ Elliott, Tim (2019-11-08). "'Crimes against humanity': is China killing political prisoners for their organs?". www.smh.com.au. Sydney Morning Herald. Retrieved 22 January 2020.
  51. ↑ Everington, Keoni (22 January 2020). "Saudis allegedly buy 'Halal organs' from 'slaughtered' Xinjiang Muslims". www.taiwannews.com.tw. Taiwan News. Retrieved 22 January 2020.
  52. 1 2 "First Known Survivor of China's Forced Organ Harvesting Speaks Out". thediplomat.com. Retrieved 2024-08-11.
  53. ↑ Cleave, Iona (2024-08-09). "Chinese organ harvesting victim woke up chained to bed with parts of liver and lung missing". The Telegraph. ISSN   0307-1235 . Retrieved 2024-08-11.
  54. ↑ Unnithan, Sandeep; Datta, Damayanti (14 February 2008). "Life and crimes of a kidney don". India Today. Retrieved 2018-12-20.
  55. ↑ "Organ Shortage Fuels Illicit Trade in Human Parts". Archived from the original on January 18, 2004. Retrieved 2008-05-01.
  56. ↑ "Hub For Global Organ Trade". Archived from the original on 2011-06-11. Retrieved 2008-05-01.
  57. ↑ "India Kidney Trade". Archived from the original on 2008-05-01. Retrieved 2008-05-01.
  58. ↑ Jafarey, Aamir (2007). "Asia's organ farms". Indian Journal of Medical Ethics . 4 (2): 52–53. PMID   18630220.
  59. ↑ Glaser, Sheri R. 2005. "Formula to Stop the Illegal Organ Trade: Presumed Consent Laws and Mandatory Reporting Requirements for Doctors". Human Rights Brief. Volume 12: Issue 20
  60. ↑ Glaser, Sheri R. (2007). "Formula to Stop the Illegal Organ Trade: Presumed Consent Laws and Mandatory Reporting Requirements for Doctors" (PDF). Human Rights Brief. Archived from the original (PDF) on 2012-01-20. Retrieved 2012-10-26.
  61. ↑ "The trade in human organs in Tamil Nadu: the anatomy of regulatory failure". Archived from the original on 2008-05-18. Retrieved 2008-05-01.
  62. ↑ "Article about organ harvesting sparks Israel-Sweden tiff" Los Angeles Times 24 August 2009
  63. 1 2 Paper's organ harvesting article causes Israel–Sweden rift, CNN 17 August 2009
  64. ↑ "U.S. Congressmen to EU: Condemn IDF organ harvesting article - Haaretz - Israel News". www.haaretz.com. Archived from the original on 2009-09-06.
  65. ↑ "CARDIN, HASTINGS CALL ON EUROPEAN LEADERS TO DENOUNCE ANTI-SEMITIC ARTICLE IN SWEDISH PRESS". Archived from the original on 10 September 2009. Retrieved 19 September 2009.
  66. ↑ Sweden: Not party to envoy's censure of IDF organ harvesting article Archived 3 December 2009 at the Wayback Machine , Haaretz 20 August 2009
  67. ↑ Tidningsutgivarna (12 August 2010). "Tafsa inte på tryck- och yttrandefriheten". Archived from the original on 29 January 2013. Retrieved 22 October 2012.
  68. ↑ Primor, Adar (31 August 2009). "Following inflammatory article, Sweden to demand EU condemn anti-Semitism". Haaretz. Retrieved 31 August 2009.
  69. ↑ Ali Waked (3 September 2009). "PA to probe 'IDF organ harvesting'". Ynetnews. Retrieved 7 September 2009.
  70. ↑ Horrid beyond words by Khalid Amayreh, published in Al-Ahram. Retrieved 26 September 2009. Archived 2009-09-28.
  71. ↑ Israelartikel ratas av kulturchefer, Svenska Dagbladet , 26 August 2009
  72. ↑ Israel harvested organs in '90s without permission Google News 20 December 2009.
  73. ↑ Black, Ian (21 December 2009). "Doctor admits Israeli pathologists harvested organs without consent". The Guardian. London. Archived from the original on 12 April 2010. Retrieved 23 April 2010.
  74. ↑ "Israel tog organ – utan tillstånd" . Retrieved 10 October 2018.
  75. ↑ "Israel". Maan News Agency. Retrieved 10 October 2018.
  76. ↑
  77. 1 2 Turner, Leigh (2009). "Commercial Organ Transplantation in the Philippines". Cambridge Quarterly of Healthcare Ethics. 18 (2): 192–96. doi:10.1017/S0963180109090318. PMID   19263601. S2CID   18672908.
  78. ↑ "Cabral warns: No more organs for sale in Philippines". Arab News. 2009-06-26. Retrieved 2018-12-20.
  79. ↑ Agence France-Presse (July 28, 2010). "Ban on human organ sales working". The Sydney Morning Herald.
  80. ↑ Scutti, Susan. "US organ transplants increased nearly 20% in five years". CNN. Retrieved 2017-12-13.
  81. 1 2 Millman, Jason (2014-09-18). "The unacceptable geographic disparities in who gets a new organ". Washington Post. ISSN   0190-8286 . Retrieved 2017-12-12.
  82. ↑ Ghaoui, Rony; Garb, Jane; Gordon, Fredric; Pomfret, Elizabeth (2015-07-08). "Impact of geography on organ allocation: Beyond the distance to the transplantation center". World Journal of Hepatology. 7 (13): 1782–1787. doi: 10.4254/wjh.v7.i13.1782 . ISSN   1948-5182. PMC   4491907 . PMID   26167251.
  83. ↑ Hainer, Ray. "Did Steve Jobs' money buy him a faster liver transplant? - CNN.com". www.cnn.com. Retrieved 2017-12-12.
  84. ↑ "hope act - OPTN". optn.transplant.hrsa.gov. Retrieved 2017-12-14.
  85. ↑ Durand, Christine M.; Segev, Dorry; Sugarman, Jeremy (2016-07-19). "Realizing HOPE: The Ethics of Organ Transplantation from HIV infected Donors". Annals of Internal Medicine. 165 (2): 138–142. doi:10.7326/M16-0560. ISSN   0003-4819. PMC   4949150 . PMID   27043422.
  86. 1 2 "At One Year Anniversary, HOPE Act Impact Continuing to be Assessed". UNOS. Nov 22, 2016.
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