PDSS2

Last updated
PDSS2
Identifiers
Aliases PDSS2 , C6orf210, COQ10D3, DLP1, bA59I9.3, hDLP1, prenyl (decaprenyl) diphosphate synthase, subunit 2, decaprenyl diphosphate synthase subunit 2, COQ1B
External IDs OMIM: 610564; MGI: 1918615; HomoloGene: 56885; GeneCards: PDSS2; OMA:PDSS2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_020381

NM_001168289
NM_027772

RefSeq (protein)

NP_065114

NP_001161761
NP_082048

Location (UCSC) Chr 6: 107.15 – 107.46 Mb Chr 10: 43.1 – 43.34 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Decaprenyl-diphosphate synthase subunit 2 (PDSS2) is a protein that in humans is encoded by the PDSS2 gene. [5]

Contents

Function

The protein encoded by this gene is an enzyme that synthesizes the prenyl side-chain of coenzyme Q, or ubiquinone, one of the key elements in the respiratory chain. The gene product catalyzes the formation of all trans-polyprenyl pyrophosphates from isopentyl diphosphate in the assembly of polyisoprenoid side chains, the first step in coenzyme Q biosynthesis. [5]

Clinical significance

It may be associated with Coenzyme Q10 deficiency. [6]

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000164494 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038240 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 "Entrez Gene: prenyl (decaprenyl) diphosphate synthase".
  6. Online Mendelian Inheritance in Man (OMIM): 607426

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.