Poly(adp-ribose) polymerase family member 14

Last updated
PARP14
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases PARP14 , ARTD8, BAL2, PARP-14, pART8, poly(ADP-ribose) polymerase family member 14
External IDs OMIM: 610028; MGI: 1919489; HomoloGene: 19697; GeneCards: PARP14; OMA:PARP14 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_017554

NM_001039530

RefSeq (protein)

NP_060024
NP_060024.2

NP_001034619

Location (UCSC) Chr 3: 122.68 – 122.73 Mb Chr 16: 35.65 – 35.69 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Poly(ADP-ribose) polymerase family member 14 is a protein that, in humans, is encoded by the PARP14 gene. [5]

Function

Poly(ADP-ribosyl)ation is an immediate DNA damage-dependent post-translational modification of histones and other nuclear proteins that contributes to the survival of injured proliferating cells. PARP14 belongs to the superfamily of enzymes that perform this modification (Ame et al., 2004 [PubMed 15273990]).

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000173193 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034422 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: Poly(ADP-ribose) polymerase family member 14" . Retrieved 2016-03-02.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.