Names | |
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IUPAC name scyllo-Inositol [1] | |
Systematic IUPAC name (1r,2r,3r,4r,5r,6r)-Cyclohexane-1,2,3,4,5,6-hexol | |
Other names Scyllitol; Cocositol; Quercinitol; AZD 103; 1,3,5/2,4,6-Hexahydroxycyclohexane; scyllo-Cyclohexanehexol | |
Identifiers | |
3D model (JSmol) | |
ChemSpider | |
ECHA InfoCard | 100.113.358 |
EC Number |
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UNII | |
CompTox Dashboard (EPA) | |
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Properties | |
C6H12O6 | |
Molar mass | 180.156 g·mol−1 |
Appearance | White crystalline solid |
Melting point | 348.5 to 350 °C (659.3 to 662.0 °F; 621.6 to 623.1 K) |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). |
scyllo-Inositol is one of the stereoisomers of inositol. It is also known as scyllitol, cocositol, quercinitol, and 1,3,5/2,4,6-hexahydroxycyclohexane. scyllo-Inositol is a naturally occurring plant sugar alcohol found most abundantly in the coconut palm. [2]
Researchers at the University of Toronto have found that scyllo-inositol can block the development of amyloid-beta (Aβ) plaques in the brains of transgenic mice. [3] scyllo-Inositol also reversed memory deficits, reduced the formation of Aβ plaques, and alleviated other symptoms that are associated with the accumulation of Aβ proteins in these mice. [4]
Researchers at the Harvard Medical School-affiliated McLean Hospital identified that chronic users of anabolic steroids had statistically significantly lower levels of brain scyllo-inositol levels as compared to non-users. [5]
scyllo-Inositol is under investigation by Transition Therapeutics as a disease-modifying therapy for Alzheimer's disease under the designation AZD-103. A patent was issued on April 21, 2009 ( U.S. Patent 7,521,481 ) claiming the use of scyllo-inositol for treating Alzheimer's disease. [6] scyllo-Inositol is undergoing clinical investigation as an orally-administered therapeutic agent for the treatment of mild to moderate Alzheimer's disease. It has received fast track designation from the U.S. Food and Drug Administration. Transition has partnered with Elan Corporation on the development of the compound under the designation ELND005. ELND005 is currently in a Phase 2 clinical study, which completed enrollment in October 2008. The study is a randomized, double-blind, placebo-controlled, dose-ranging, safety and efficacy study in approximately 353 patients with mild to moderate Alzheimer's disease. The planned treatment period for each patient is approximately 18 months.
In December 2009, Elan and Transition jointly reported that the study has been modified so that only the 250 mg twice daily dose will be continued because of greater rates of adverse events, including 9 deaths, in the higher dose groups (1000 mg and 2000 mg dosed twice daily). [7] Although the clinical trial helped establish the safety profile, the removal of the higher dose groups reduced the power of the study to establish efficacy. [8]
Inositol, primarily the isomer myo-inositol, is a carbocyclic sugar that is abundant in the brain and other mammalian tissues; it mediates cell signal transduction in response to a variety of hormones, neurotransmitters, and growth factors and participates in osmoregulation. Concerning regulation of osmosis, in most mammalian cells the intracellular concentrations of myo-inositol are 5 to 500 times greater than the extracellular concentrations.
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