Secoisolariciresinol dehydrogenase

Secoisolariciresinol dehydrogenase
Identifiers
EC no.	1.1.1.331
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Secoisolariciresinol dehydrogenase (EC 1.1.1.331) is an enzyme with the systematic name (-)-secoisolariciresinol:NAD⁺ oxidoreductase. ^{[1] [2] [3]} This enzyme catalyses the following chemical reaction: ^[4]

secoisolariciresinol

+ 2 NAD⁺

 

 

 

2 H⁺

 

2 H⁺

 

matairesinol

+ 2 NADH

 

This enzyme is isolated from the plants Forsythia intermedia and Podophyllum peltatum .

References

1. Xia ZQ, Costa MA, Pelissier HC, Davin LB, Lewis NG (April 2001). "Secoisolariciresinol dehydrogenase purification, cloning, and functional expression. Implications for human health protection". The Journal of Biological Chemistry. 276 (16): 12614–23. doi: 10.1074/jbc.M008622200 . PMID   11278426.
2. Youn B, Moinuddin SG, Davin LB, Lewis NG, Kang C (April 2005). "Crystal structures of apo-form and binary/ternary complexes of Podophyllum secoisolariciresinol dehydrogenase, an enzyme involved in formation of health-protecting and plant defense lignans". The Journal of Biological Chemistry. 280 (13): 12917–26. doi: 10.1074/jbc.M413266200 . PMID   15653677.
3. Moinuddin SG, Youn B, Bedgar DL, Costa MA, Helms GL, Kang C, Davin LB, Lewis NG (March 2006). "Secoisolariciresinol dehydrogenase: mode of catalysis and stereospecificity of hydride transfer in Podophyllum peltatum". Organic & Biomolecular Chemistry. 4 (5): 808–16. doi:10.1039/b516563f. PMID   16493463.
4. Enzyme 1.1.1.331 at KEGG Pathway Database.

External links

• Secoisolariciresinol+dehydrogenase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)