U.S. Route 33 (US 33) is a United States Numbered Highway that runs northwest–southeast for 709 miles (1,141 km) from northern Indiana to Richmond, Virginia, passing through Ohio and West Virginia en route. Although most odd-numbered U.S. routes are north–south, US 33 is labeled east–west throughout its route, except in Indiana where it is labeled north–south. It roughly follows a historic trail used by Native Americans from Chesapeake Bay to Lake Michigan.
U.S. Route 58 is an east–west U.S. Highway that runs for 508 miles (818 km) from U.S. Route 25E just northwest of Harrogate, Tennessee, to U.S. Route 60 in Virginia Beach, Virginia. Until 1996, when the Cumberland Gap Tunnel opened, US 58 ran only inside the commonwealth of Virginia. It was then extended southwest along a short piece of former US 25E, which no longer enters Virginia, to end at the new alignment in Tennessee. For most of its alignment, it closely parallels Virginia's southern border with North Carolina.
U.S. Route 522 is a spur route of US 22 in the states of Virginia, West Virginia, Maryland, and Pennsylvania. The U.S. Highway travels in a north-south direction, and runs 308.59 miles (496.63 km) from US 60 near Powhatan, Virginia, to its northern terminus at US 11 and US 15 near Selinsgrove, Pennsylvania. US 522 serves many small cities and towns in the Piedmont, Blue Ridge Mountains, and northern Shenandoah Valley of Virginia. The highway serves the Virginia communities of Goochland, Mineral, Culpeper, the town of Washington, and Front Royal and the independent city of Winchester. US 522 then follows the Ridge-and-Valley Appalachians north and then east through the Eastern Panhandle of West Virginia, a 2-mile-wide (3.2 km) stretch of Western Maryland, and South Central Pennsylvania to its terminus in the Susquehanna Valley. The highway serves Berkeley Springs, West Virginia; Hancock, Maryland; and the Pennsylvania communities of McConnellsburg, Mount Union, Lewistown, and Middleburg.
State Route 259 is a primary state highway in the U.S. state of Virginia. The state highway runs a total of 26.80 miles (43.13 km) in two sections. The southern section, in northern Rockingham County, has a length of 21.81 miles (35.10 km) from Interstate 81 (I-81) and U.S. Route 11 at Mauzy through Broadway to the West Virginia state line into Mathias. The northern section, in western Frederick County, covers 4.99 miles (8.03 km) from the West Virginia state line north to US 50 at Gore. The two sections of SR 259 are joined by West Virginia Route 259.
State Route 6 is a primary state highway in the U.S. state of Virginia. Known for most of its length as River Road, the state highway runs 102.26 miles (164.57 km) from U.S. Route 250 in Afton east to SR 161 in Richmond. SR 6 is one of the main highways of mountainous Nelson County, where the highway runs north–south from its beginning to US 29. From Scottsville to Richmond, the state highway parallels the James River. SR 6 is a major suburban highway through southwestern Henrico County and the main street of Richmond's West End.
State Route 71 is a primary state highway in the southwest part of the U.S. state of Virginia. It runs from Gate City northeast to Lebanon, mostly through river valleys. Despite running more east–west than north–south, it is signed north–south; it parallels the similarly-oriented U.S. Route 11 and Interstate 81.
State Route 16 is a primary state highway in the southwest part of the U.S. state of Virginia. It runs from the North Carolina border at North Carolina Highway 16 north to the West Virginia border at West Virginia Route 16, passing through the towns of Troutdale, Marion, and Tazewell. Highway 16 is part of a three-state route 16 that connects the Charlotte region with northwestern West Virginia.
State Route 80 is a primary state highway in the southwest part of the U.S. state of Virginia. It runs from the Kentucky state line at Breaks Interstate Park east to U.S. Route 11 near Meadowview. Kentucky Route 80 and Missouri's Route 80 continue the number west to Matthews, Missouri. The entire length of SR 80 is part of U.S. Bicycle Route 76.
State Route 91 is a primary state highway in the U.S. state of Virginia. The state highway runs 55.12 miles (88.71 km) from the Tennessee state line near Damascus, where the highway continues as Tennessee State Route 91, north to U.S. Route 19 Business and US 460 Business at Frog Level. SR 91 connects Damascus in southeastern Washington County with the northeastern county town Glade Spring, where the highway has junctions with US 11 and Interstate 81 (I-81). The state highway also indirectly connects Saltville in northwestern Smyth County and Tazewell, the county seat of Tazewell County. SR 91 is the only primary state highway in Virginia with an unpaved section; this gravel section is in southern Tazewell County.
State Route 61 is a primary state highway in the U.S. state of Virginia. The state highway runs 48.16 miles (77.51 km) from SR 16 in Tazewell east to U.S. Route 460 in Narrows. SR 61 passes through several narrow creek valleys as it parallels the West Virginia state line through Tazewell, Bland, and Giles counties. The only sizeable community between the highway's endpoints is Rocky Gap, where the highway meets US 52 and Interstate 77 (I-77).
State Route 40 is a primary state highway in the southern part of the U.S. state of Virginia. It runs from SR 8 at Woolwine east to SR 10 at Spring Grove, about half the width of Virginia. It is the longest state-numbered route in Virginia.
U.S. Route 33 is a part of the U.S. Highway System that runs from Elkhart, Indiana to Richmond, Virginia. In Virginia, the U.S. Highway runs 135.60 miles (218.23 km) from the West Virginia state line near Rawley Springs east to its eastern terminus at SR 33 in Richmond. US 33 is the primary east–west highway of Rockingham County, which lies in the Shenandoah Valley. The highway connects the independent city of Harrisonburg, the town of Elkton, and an entrance to Shenandoah National Park. East of the Blue Ridge Mountains, US 33 connects the Piedmont communities of Stanardsville, Gordonsville, and Louisa. The U.S. Highway is a major suburban and urban route in the Richmond metropolitan area. Within Richmond, US 33 runs concurrently with US 250. SR 33 continues from US 33's eastern terminus as a state-numbered extension of the U.S. Highway that connects Richmond with Virginia's Middle Peninsula.
State Route 39 is a primary state highway in the U.S. state of Virginia. The state highway runs 59.17 miles (95.22 km) from the West Virginia state line near Mountain Grove, where the highway continues as West Virginia Route 39, east to U.S. Route 11 in East Lexington. SR 39 connects Lexington with several communities formed around hot springs in Bath County. In Rockbridge County, the state highway passes through the town of Goshen and Goshen Pass, a gorge formed by the Maury River.
State Route 100 is a primary state highway in the U.S. state of Virginia. The state highway runs 53.31 miles (85.79 km) from U.S. Route 221 in Hillsville north to SR 61 in Narrows. SR 100 is one of the major highways of the New River Valley, connecting Narrows and Pearisburg in Giles County with Dublin, Pulaski, and Interstate 81 (I-81) in Pulaski County.
State Route 254 is a primary state highway in the U.S. state of Virginia. The state highway runs 25.01 miles (40.25 km) from SR 42 near Buffalo Gap east to U.S. Route 340 in Waynesboro. SR 254 provides a northerly alternate route to US 250 between Waynesboro and Staunton, where the highway provides access to the Woodrow Wilson Presidential Library.
State Route 211 is a primary state highway in the U.S. state of Virginia. The state highway runs 5.63 miles (9.06 km) from SR 42 in Timberville east to Interstate 81 (I-81) and U.S. Route 211 in New Market. SR 211 is a state-numbered westward extension of US 211.
State Route 257 is a primary state highway in the U.S. state of Virginia. The state highway runs 18.04 miles (29.03 km) from SR 902 and SR 924 near Briery Branch east to Interstate 81 (I-81) near Mount Crawford. SR 257 connects I-81 and U.S. Route 11 with Bridgewater and Dayton, between which the highway runs concurrently with SR 42. The state highway also provides access to Bridgewater College and connects Dayton with the western Rockingham County communities of Briery Branch, Ottobine and Montezuma.
Interstate 81 (I-81) is an 855.02-mile-long (1,376.02 km) Interstate Highway. In the US state of Virginia, I-81 runs for 324.92 miles (522.91 km), making the portion in Virginia longer than any other state's portion of the route. It is also the longest Interstate Highway within the borders of Virginia. It stretches from the Tennessee state line near Bristol to the West Virginia state line near Winchester. It enters Virginia from Bristol, Tennessee, and leaves Virginia into Berkeley County, West Virginia. The route passes through the cities of Bristol, Roanoke, Lexington, Staunton, and Harrisonburg.
U.S. Route 250 is a part of the U.S. Highway System that runs from Sandusky, Ohio to Richmond, Virginia. In Virginia, the highway runs 166.74 miles (268.34 km) from the West Virginia state line near Hightown east to its eastern terminus at US 360 in Richmond. US 250 is the main east–west highway of Highland County, which is known as Virginia's Little Switzerland; the highway follows the path of the 19th century Staunton and Parkersburg Turnpike. From Staunton east to Richmond, the highway serves as the local complement to Interstate 64 (I-64), roughly following the 18th century Three Notch'd Road through Waynesboro and Charlottesville on its way through the Shenandoah Valley, its crossing of the Blue Ridge Mountains at Rockfish Gap, and the Piedmont. In the Richmond metropolitan area, US 250 is known as Broad Street, a major thoroughfare through the city's West End and downtown areas.
U.S. Route 33 (US 33) in the U.S. state of West Virginia extends 248 miles (399 km) from the Ohio River at Ravenswood to the Virginia state line atop Shenandoah Mountain west of Harrisonburg, Virginia.
Virginia Byway 
SR 91 in Broadford 
SR 100 in Poplar Hill 
US 460 / SR 605 in Newport 
SR 311 / SR 615 in New Castle 
SR 269 / SR 632 near Nicelytown 
US 11 / SR 670 in Woodstock
