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Routes of administration | Oral |
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Elimination half-life | 7–27 hours |
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Formula | C20H25NO2 |
Molar mass | 311.425 g·mol−1 |
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Femoxetine (INN; tentative brand name Malexil; developmental code name FG-4963) is a drug related to paroxetine that was being developed as an antidepressant by Danish pharmaceutical company Ferrosan in 1975 before acquisition of the company by Novo Nordisk. It acts as a selective serotonin reuptake inhibitor (SSRI). Development was halted to focus attention on paroxetine instead, as femoxetine could not be administered as a daily pill.
Both femoxetine and paroxetine were invented in the 1970s. Jørgen Anders Christensen's name is on the patents [1] [2] and Jorgen Buus-Lassen's name is on the pharmacology paper. [3]
After Ferrosan's acquisition, femoxetine died from neglect. [4]
In a separate patent, Ferrosan stated that Femoxetine could be used as an appetite suppressant, [5] using ten times the dosage than for paroxetine, 300 - 400mg daily.
Femoxetine has the same stereochemical properties as Nocaine, another agent with a similar structure claimed to have been synthesized using arecoline as the starting alkaloid.[ citation needed ]
This section may be too technical for most readers to understand.(March 2022) |
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Jørgen Buus Lassen femoxetine.