March 30 – William Johnston and Paul West's novel The Innocent Murderers is published in New York City, as the first work of academic crime fiction.
April 20 – Halley's comet reappears after 76 years, and Mark Twain dies at his home, Stormfield, the day after the comet's perihelion. In his autobiography, Twain wrote, "I came in with Halley's comet in 1835. It's coming again next year (1910), and I expect to go out with it. The Almighty has said no doubt, 'Now here are these two unaccountable freaks; they came in together, they must go out together.'"
Five Lectures on Psycho-Analysis (Über Psychoanalyse: fünf Vorlesungen gehalten zur 20jährigen Gründungsfeier der Clark University in Worcester Mass., September 1909)
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