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1910 in science |
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The year 1910 in science and technology involved some significant events, listed below.
Arsphenamine, also known as Salvarsan or compound 606, is an antibiotic drug that was introduced at the beginning of the 1910s as the first effective treatment for the deadly infectious diseases syphilis, relapsing fever, and African trypanosomiasis. This organoarsenic compound was the first modern antimicrobial agent.
The year 1908 in science and technology involved some significant events, listed below.
The year 1909 in science and technology involved some significant events, listed below.
The year 1911 in science and technology involved some significant events, listed below.
The year 1982 in science and technology involved many significant events, listed below.
The year 1947 in science and technology involved some significant events, listed below.
James Bryan Herrick was an American physician and professor of medicine who practiced and taught in Chicago. He is credited with the description of sickle-cell disease and was one of the first physicians to describe the symptoms of myocardial infarction.
Sahachirō Hata was a prominent Japanese bacteriologist who researched the bubonic plague under Kitasato Shibasaburō and assisted in developing the antisyphilitic drug arsphenamine in 1909 in the laboratory of Paul Ehrlich.
Rous sarcoma virus (RSV) is a retrovirus and is the first oncovirus to have been described. It causes sarcoma in chickens.
Francis Peyton Rous was an American pathologist at the Rockefeller University known for his works in oncoviruses, blood transfusion and physiology of digestion. A medical graduate from the Johns Hopkins University, he was discouraged from becoming a practicing physician due to severe tuberculosis. After three years of working as an instructor of pathology at the University of Michigan, he became dedicated researcher at the Rockefeller Institute for Medical Research for the rest of his career.
Nicosan, also known as Hemoxin, Niprisan, or Nix-0699, is a phytochemical which was studied in sickle-cell disease (SCD). As of 2017 it does not appear to be commercially available, as the only manufacturer, which was in Nigeria, has stopped producing it due to financial problems.
The year 1931 in science and technology involved some significant events, listed below.
Harvey Akio Itano was an American biochemist best known for his work on the molecular basis of sickle cell anemia and other diseases. In collaboration with Linus Pauling, Itano used electrophoresis to demonstrate the difference between normal hemoglobin and sickle cell hemoglobin; their 1949 paper "Sickle Cell Anemia, a Molecular Disease" was a landmark in both molecular medicine and protein electrophoresis, though the use of electrophoresis to separate hemoglobin variants had been pioneered by Maud Menten and collaborators some years earlier.
"Sickle Cell Anemia, a Molecular Disease" is a 1949 scientific paper by Linus Pauling, Harvey A. Itano, Seymour J. Singer and Ibert C. Wells that established sickle-cell anemia as a genetic disease in which affected individuals have a different form of the metalloprotein hemoglobin in their blood. The paper, published in the November 25, 1949 issue of Science, reports a difference in electrophoretic mobility between hemoglobin from healthy individuals and those with sickle-cell anemia, with those with sickle cell trait having a mixture of the two types. The paper suggests that the difference in electrophoretic mobility is probably due to a different number of ionizable amino acid residues in the protein portion of hemoglobin, and that this change in molecular structure is responsible for the sickling process. It also reports the genetic basis for the disease, consistent with the simultaneous genealogical study by James V. Neel: those with sickle-cell anemia are homozygous for the disease gene, while heterozygous individuals exhibit the usually asymptomatic condition of sickle cell trait.
Sickle cell disease (SCD), also simply called sickle cell, is a group of hemoglobin-related blood disorders that are typically inherited. The most common type is known as sickle cell anemia. Sickle cell anemia results in an abnormality in the oxygen-carrying protein haemoglobin found in red blood cells. This leads to the red blood cells adopting an abnormal sickle-like shape under certain circumstances; with this shape, they are unable to deform as they pass through capillaries, causing blockages. Problems in sickle cell disease typically begin around 5 to 6 months of age. A number of health problems may develop, such as attacks of pain in joints, anemia, swelling in the hands and feet, bacterial infections, dizziness and stroke. The probability of severe symptoms, including long-term pain, increases with age. Without treatment, people with SCD rarely reach adulthood but with good healthcare, median life expectancy is between 58 and 66 years. All of the major organs are affected by sickle cell disease. The liver, heart, kidneys, gallbladder, eyes, bones, and joints can be damaged from the abnormal functions of the sickle cells and their inability to effectively flow through the small blood vessels.
Andrew M. Davis is an American meteoriticist and professor of astronomy and geoscience at the University of Chicago. He is the son of American chemist and physicist Raymond Davis Jr., a Nobel Prize in Physics laureate. His main field of study is the origin of the elements by stellar nucleosynthesis. He currently is the head of a project to build a new instrument called the ion nanoprobe, which will allow isotopic and chemical analysis at finer scales than any contemporary instrument. He is also studying the cometary dust and contemporary interstellar dust returned to Earth by the Stardust spacecraft in 2006. In 2018, he was made Fellow of the American Association for the Advancement of Science.
Ernest Edward Irons was an American physician who led several prominent medical organizations. Working as an intern under physician James B. Herrick, he identified abnormalities on a blood smear that resulted in the first published report of sickle cell disease.
William Warrick Cardozo (1905–1962) was an accomplished private physician and pediatrician who also served as an instructor at the Howard University College of Medicine and as a school medical inspector for the District of Columbia Board of Health. He is best known for his research on sickle cell anemia, but also published articles about Hodgkin's disease, the gastrointestinal health of children, and the physical development of African American children. Cardozo was an early African-American contributor in the healthcare profession.
The Hodgkin family is a British Quaker family where several members have excelled in science, medicine, and arts.
John Graydon Kidd was an American physician, pathologist, and virologist.