The Eastern Conference is one of Major League Soccer's two conferences, along with the Western Conference. The division of the conferences broadly follows the path of the Mississippi River from the Great Lakes to the Gulf of Mexico, with clubs east of the river in the Eastern Conference.
The 2020 Nashville SC season was the club's first season as an organization and its first season as a member of Major League Soccer, after two seasons in the Eastern Conference of the USL Championship by a club of the same name.
The 2021 Inter Miami CF season was the second season in the history of Inter Miami CF and the 18th season of first-division club soccer in South Florida. In addition to playing in Major League Soccer, the club was scheduled to participate in the U.S. Open Cup but the competition was cancelled for the second consecutive year due to the COVID-19 pandemic.
The 2021 Nashville SC season was the club's second season as a member of Major League Soccer. This was the club's last season in the Eastern Conference after being added to the Conference in 2020 after the MLS is Back Tournament as the club returns to the Western Conference the following season in 2022 due to the addition of Charlotte FC.
The 2022 Columbus Crew season was the club's twenty-seventh season of existence and their twenty-seventh consecutive season in Major League Soccer, the top flight of American soccer. The season covered the period from November 8, 2021 to the end of the 2022 season. It was the fourth and final season under head coach Caleb Porter.
The 2023 Inter Miami CF season was the fourth season in the history of Inter Miami CF and the 20th season of first-division club soccer in South Florida. In addition to playing in Major League Soccer, the club participated in the U.S. Open Cup and the new-look Leagues Cup for the first time.
The 2023 Nashville SC season was the fourth season for Nashville SC as a member of Major League Soccer (MLS), the top flight of professional soccer in the United States. After finishing the 2022 season with a playoff berth and a first round exit, the club loaned out Designated Player and forward Aké Arnaud Loba to Mazatlán F.C. and made trades to add depth. Midfielder Hany Mukhtar had finished the previous season as the league's top goalscorer, earning the MLS Golden Boot with 23 goals, and was also won the most valuable player award.
The 2024 Inter Miami CF season was the fifth season in the history of Inter Miami CF and the 21st season of first-division club soccer in South Florida. The team were in their fifth year as a member of the Eastern Conference of Major League Soccer (MLS). In addition to playing in the MLS regular season, the club participated in the MLS Cup playoffs, in the CONCACAF Champions Cup for the first time, and in the Leagues Cup as defending champions.
The 2024 Columbus Crew season was the club's twenty-ninth season of existence and their twenty-ninth consecutive season in Major League Soccer, the top flight of soccer in the United States. It was their second season under head coach Wilfried Nancy. The Crew are defending MLS Cup champions, having won the 2023 MLS Cup against Los Angeles FC. On December 20, 2023, MLS released its schedule, with Columbus playing its opening match of the season against Atlanta United FC at home on February 24.
The 2024 Nashville SC season was the fifth season for Nashville SC as a member of Major League Soccer (MLS), the top flight of professional soccer in the United States.
The 2025 Major League Soccer season will be the 30th season of Major League Soccer (MLS), the top professional soccer league in the United States and Canada, and the 47th season overall of a national first-division league in the United States.
The 2025 Inter Miami CF season will be the sixth season for Inter Miami CF, a professional soccer team based in Miami, Florida, United States. The team plays in Major League Soccer (MLS), the top flight of club soccer in the United States, as a member of the Eastern Conference. The year also marks the 22nd season of first-division club soccer in South Florida. In addition to playing in the MLS regular season, Inter Miami CF will compete in the CONCACAF Champions Cup for the second time and the FIFA Club World Cup for the first time.
The 2025 CF Montréal season will be the club's 32nd season of existence, and their 14th in Major League Soccer, the top tier of the American soccer pyramid.
The 2025 Atlanta United FC season will be the ninth season of Atlanta United FC's existence, and the seventeenth year that a professional soccer club from Atlanta, Georgia will compete in the top division of American soccer. Atlanta United play their home games at Mercedes-Benz Stadium. Outside of MLS, they will compete in the 2025 U.S. Open Cup and the 2025 Leagues Cup.
The 2025 season will be the LA Galaxy's 30th season in Major League Soccer, the top tier of the American soccer pyramid. LA Galaxy will play their home matches at Dignity Health Sports Park in the Los Angeles suburb of Carson, California. The Galaxy will open the season on February 23, 2025, hosting expansion side San Diego FC.
The 2025 season will be the fourth season for Charlotte FC in Major League Soccer (MLS), the top flight of professional club soccer in the United States.The team is based in Charlotte, North Carolina, and was established in 2019. They made their MLS debut in the 2022 season. The 2025 season will be their second for Charlotte FC under English head coach Dean Smith, who was hired in December 2023 and was the team's third manager.
The 2025 season will be the 10th season for FC Cincinnati and their 7th in Major League Soccer (MLS), the highest level of men's professional soccer in the United States. Their home stadium is TQL Stadium. It is the fourth season with the club for general manager Chris Albright and head coach Pat Noonan.
The 2025 Columbus Crew season will be the club's 30th season of existence and their 30th consecutive season in Major League Soccer, the top flight of soccer in the United States. It will be their third season under head coach Wilfried Nancy.
The 2025 Philadelphia Union season is the club's sixteenth season in Major League Soccer, the top flight of American soccer. The club's regular season began on February 22, 2025, opening against Orlando City SC. The club will also participate in the 2023 Leagues Cup.
The 2025 Houston Dynamo season is the 20th season of the team's existence since joining Major League Soccer (MLS) prior to the 2006 season. 2025 is the third season under head coach Ben Olsen and the fourth season under GM Pat Onstad and technical director Asher Mendelsohn. It is the fifth season under majority owner Ted Segal.