The 2020 Inter Miami CF season was the first season in the history of Inter Miami CF and the 17th season of first-division club soccer in South Florida. It was the first time since 2001 that a South Florida club competed in the first-division. In addition to playing in Major League Soccer, the club was scheduled to participate in the U.S. Open Cup but the competition was cancelled due to the COVID-19 pandemic.
The 2020 Atlanta United FC season was the fourth season of Atlanta United FC's existence, and the twelfth year that a professional soccer club from Atlanta, Georgia competed in the top division of American soccer. Atlanta United played their home games at Mercedes-Benz Stadium. Outside of MLS, the team made their second appearance in the CONCACAF Champions League, and were set to participate in the 2020 U.S. Open Cup as defending champions, before the tournament's cancelation due to the COVID-19 pandemic.
The 2020 FC Cincinnati season was the club's second season in MLS, and the fifth season of a team playing under the FC Cincinnati brand after three years in the lower-division USL Championship. The club finished with a league worst 6–22–6 record in their inaugural MLS season in 2019, setting a league record for the most goals given up with 75. The 2020 season was the final year that FC Cincinnati played home matches at Nippert Stadium, as their new West End Stadium is scheduled to open in March 2021.
The 2020 Nashville SC season was the club's first season as an organization and its first season as a member of Major League Soccer, after two seasons in the Eastern Conference of the USL Championship by a club of the same name.
The 2020 New York City FC season was the club's sixth season of competition and its sixth in the top tier of American soccer, Major League Soccer. New York City FC usually played its home games at Yankee Stadium in the New York City borough of The Bronx. However, the 2020 MLS season saw the club play several of their home games at Red Bull Arena in Harrison, New Jersey due to scheduling conflicts at both Yankee Stadium and Citi Field as well as winterization procedures during the 2020 CONCACAF Champions League which were unavoidable.
The 2021 FC Cincinnati season was the club's third season in MLS, and the sixth season of a team playing under the FC Cincinnati brand after three years in the lower-division USL Championship. The club finished with a league worst 4–15–4 record in their second MLS season in 2020, one shortened by the COVID-19 pandemic in Ohio. The season was the first year that FC Cincinnati played home matches at newly built TQL Stadium.
The 2021 Club de Foot Montréal season was the club's 28th season of existence, and their tenth in Major League Soccer, the top tier of the American soccer pyramid. This was the first season under the club's new name, being known as the Montreal Impact up until this point.
The 2021 Columbus Crew season was the club's twenty-sixth season of existence and their twenty-sixth consecutive season in Major League Soccer, the top flight of American soccer. The season covers the period from December 13, 2020, to November 7, 2021. It is the third season under head coach Caleb Porter.
The 2022 FC Cincinnati season was the club's fourth season in MLS, and the seventh season playing under the FC Cincinnati brand after three years in the lower-division USL Championship. FC Cincinnati home matches were played at TQL Stadium.
The 2022 Club de Foot Montréal season was the club's 29th season of existence, and their 11th in Major League Soccer (MLS), the top tier of the American soccer pyramid.
The 2022 Columbus Crew season was the club's twenty-seventh season of existence and their twenty-seventh consecutive season in Major League Soccer, the top flight of American soccer. The season covered the period from November 8, 2021 to the end of the 2022 season. It was the fourth and final season under head coach Caleb Porter.
The 2022 Inter Miami CF season was the third season in the history of Inter Miami CF and the 19th season of first-division club soccer in South Florida. In addition to playing in Major League Soccer, the club participated in the U.S. Open Cup, the first cup competition in club history.
The 2023 season was D.C. United's 28th in existence and its 28th consecutive season in the top division of American soccer, Major League Soccer. In addition to MLS, D.C. United participated in the 2023 U.S. Open Cup and 2023 Leagues Cup, the latter their first international club tournament since 2016. The season was the first full season with Wayne Rooney as head coach. The season covered the period from November 1, 2022, to October 31, 2023.
The 2023 New York Red Bulls season was the club's twenty-eighth season in Major League Soccer, the top division of soccer in the United States.
The 2023 CF Montréal season was the club's 30th season of existence, and their 12th in Major League Soccer, the top tier of the American soccer pyramid.
The 2023 Inter Miami CF season was the fourth season in the history of Inter Miami CF and the 20th season of first-division club soccer in South Florida. In addition to playing in Major League Soccer, the club participated in the U.S. Open Cup and the new-look Leagues Cup for the first time.
The 2025 season will be D.C. United's 30th in existence and its 30th consecutive season in the top division of American soccer, Major League Soccer. Pending announcements from the club, it is expected that the team will participate in the 2025 U.S. Open Cup and the 2025 Leagues Cup in addition to MLS play.
The 2025 CF Montréal season will be the club's 32nd season of existence, and their 14th in Major League Soccer, the top tier of the American soccer pyramid.
The 2025 season will be the LA Galaxy's 30th season in Major League Soccer, the top tier of the American soccer pyramid. LA Galaxy will play their home matches at Dignity Health Sports Park in the Los Angeles suburb of Carson, California. The Galaxy will open the season on February 23, 2025, hosting expansion side San Diego FC.
The 2025 season will be the sixth season for Nashville SC as a member of Major League Soccer (MLS), the top flight of professional soccer in the United States. It is their eighth overall season, including two years in the second-division USL Championship.