Cardiac glycosides are a class of organic compounds that increase the output force of the heart and decrease its rate of contractions by inhibiting the cellular sodium-potassium ATPase pump. Their beneficial medical uses are as treatments for congestive heart failure and cardiac arrhythmias; however, their relative toxicity prevents them from being widely used. Most commonly found as secondary metabolites in several plants such as foxglove plants, these compounds nevertheless have a diverse range of biochemical effects regarding cardiac cell function and have also been suggested for use in cancer treatment.
Digitalis is a genus of about 20 species of herbaceous perennial plants, shrubs, and biennials, commonly called foxgloves.
Calendula is a genus of about 15–20 species of annual and perennial herbaceous plants in the daisy family, Asteraceae that are often known as marigolds. They are native to southwestern Asia, western Europe, Macaronesia, and the Mediterranean. Other plants known as marigolds include corn marigold, desert marigold, marsh marigold, and plants of the genus Tagetes.
Atropine is a tropane alkaloid and anticholinergic medication used to treat certain types of nerve agent and pesticide poisonings as well as some types of slow heart rate, and to decrease saliva production during surgery. It is typically given intravenously or by injection into a muscle. Eye drops are also available which are used to treat uveitis and early amblyopia. The intravenous solution usually begins working within a minute and lasts half an hour to an hour. Large doses may be required to treat some poisonings.
Actaea racemosa, the black cohosh, black bugbane, black snakeroot, rattle-top, or fairy candle, is a species of flowering plant of the family Ranunculaceae. It is native to eastern North America from the extreme south of Ontario to central Georgia, and west to Missouri and Arkansas. It grows in a variety of woodland habitats, and is often found in small woodland openings. The roots and rhizomes were used in traditional medicine by Native Americans. Its extracts are manufactured as herbal medicines or dietary supplements. Most dietary supplements containing black cohosh are not well-studied or recommended for safe and effective use in treating menopause symptoms or any disease. In contrast, some herbal medicinal products containing black cohosh extract hold a marketing authorization in several states of the European Union and are well-studied and recommended for safe and effective use for the relief of menopausal symptoms such as hot flushes and profuse sweating attacks. Such differentiation between the product types seems to be important.
Adonis is a genus of about 20–30 species of flowering plants of the crowfoot family, Ranunculaceae, native to Europe and Asia.
Medicinal plants, also called medicinal herbs, have been discovered and used in traditional medicine practices since prehistoric times. Plants synthesize hundreds of chemical compounds for various functions, including defense and protection against insects, fungi, diseases, and herbivorous mammals.
Phytochemistry is the study of phytochemicals, which are chemicals derived from plants. Phytochemists strive to describe the structures of the large number of secondary metabolites found in plants, the functions of these compounds in human and plant biology, and the biosynthesis of these compounds. Plants synthesize phytochemicals for many reasons, including to protect themselves against insect attacks and plant diseases. The compounds found in plants are of many kinds, but most can be grouped into four major biosynthetic classes: alkaloids, phenylpropanoids, polyketides, and terpenoids.
Eranthis is a genus of eight species of flowering plants in the buttercup family Ranunculaceae, native to southern Europe and east across Asia to Japan. The common name winter aconite comes from the early flowering time and the resemblance of the leaves to those of the related genus Aconitum, the true aconite. Like the notoriously toxic AconitumEranthis is poisonous, although its chemistry is different, the toxic compounds present being mainly cardiac glycosides of the bufadienolide group similar to those found in Adonis vernalis, rather than the virulent alkaloids of Aconitum.
Eranthis hyemalis, the winter aconite, is a species of flowering plant in the buttercup family Ranunculaceae, native to calcareous woodland habitats in France, Italy and the Balkans, and widely naturalized elsewhere in Europe.
Digitalis lanata, vernacularly often called woolly foxglove or Grecian foxglove, is a species of foxglove, a flowering plant in the plantain family Plantaginaceae. It gets its name due to the woolly indumentum of the leaves. D. lanata, like other foxglove species, is toxic in all parts of the plant. Symptoms of digitalis poisoning include nausea, vomiting, severe headache, dilated pupils, problems with eyesight, and convulsions at the worst level of toxicity. The plant is also harmful to other animals.
Leonotis leonurus, also known as lion's tail and wild dagga, is a plant species in the mint family, Lamiaceae. The plant is a broadleaf evergreen large shrub native to South Africa, where it is very common. It is known for its medicinal properties. The main psychoactive component of Leonotis leonurus is hypothesized to be related to the presence of leonurine or labdanes, Leonotis leonurus has been confirmed to contain Leonurine according to peer reviewed journal published phytochemical analysis. Like other plants in the mint family, it also contains marrubiin. The word "dagga" comes from Afrikaans, and derives in turn from the Khoikhoi "dachab". The word "dagga" has been extended to include cannabis in Afrikaans and South African English, so the use of "wild" serves to distinguish Leonotis leonuris from this.
Decoction is a method of extraction by boiling herbal or plant material to dissolve the chemicals of the material. It is the most common preparation method in various herbal-medicine systems. Decoction involves first drying the plant material; then mashing, slicing, or cutting the material to allow for maximum dissolution; and finally boiling in water to extract oils, volatile organic compounds and other various chemical substances. Occasionally, aqueous ethanol or glycerol may be used instead of water. Decoction can be used to make tisanes, tinctures and similar solutions. Decoctions and infusions may produce liquids with differing chemical properties, as the temperature or preparation difference may result in more oil-soluble chemicals in decoctions versus infusions. The process can also be applied to meats and vegetables to prepare bouillon or stock, though the term is typically only used to describe boiled plant extracts, usually for medicinal or scientific purposes.
Adonis aestivalis, the summer pheasant's-eye, is a medicinal and ornamental plant. It is native to Europe and Asia but has been introduced elsewhere, such as the western and eastern parts of the United States, as an ornamental plant. In particular, it has been known to invade alfalfa fields, contaminating feed used for horse hay. It is a member of the buttercup family. It is an annual herb.
Adonis annua, also known as pheasant's-eye, Adonis' flower, autumn Adonis, autumn pheasant's-eye, blooddrops, red chamomile, red Morocco, rose-a-ruby, and soldiers-in-green, is an ornamental plant of the family Ranunculaceae.
Calotropis gigantea, the crown flower, is a species of Calotropis native to Cambodia, Vietnam, Bangladesh, Indonesia, Malaysia, Thailand, Sri Lanka, India, China, Pakistan, and Nepal.
Drimia maritima is a species of flowering plant in the family Asparagaceae, subfamily Scilloideae. This species is known by several common names, including squill, sea squill, sea onion, and maritime squill. It may also be called red squill, particularly a form which produces red-tinged flowers instead of white. It is native to southern Europe, western Asia, and northern Africa.
Mephentermine is a cardiac stimulant.
Bekhterev's mixture is a medicine with a sedative effect, affecting the central nervous system. The mixture was proposed by Russian neurologist Vladimir Bekhterev as a treatment for mild forms of epilepsy and heart disease in 1898. It was subsequently named after him. One of the oldest and most popular medicines of its type, it is used to treat light forms of heart failure, panic disorder, and dystonia. The medicine is known to be well tolerated, with no contra-indications, except bromine sensitivity.
Strophanthus kombe, the kombe arrow poison, is a vine that grows in the tropical regions of Eastern Africa, and is part of the genus Strophanthus, which contains approximately 38 species. S. kombe contains a cardiac glycoside which directly affects the heart. Historically, both the seeds and roots of the plant were used in the preparation of poison arrowheads used for hunting. Today, the seeds are used pharmaceutically for patients with certain heart conditions that affect blood circulation. The seeds are traded primarily with Europe, but have also been exported to the United States and Japan.
