Atrolysin F

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Atrolysin F
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EC no. 3.4.24.45
CAS no. 172306-52-4
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Atrolysin F (EC 3.4.24.45, Crotalus atrox metalloendopeptidase, hemorrhagic toxin f, Crotalus atrox metalloendopeptidase f) is an enzyme. [1] This enzyme catalyses the following chemical reaction

Cleavage of Val2-Asn, Gln4-His, Leu6-Cys, His10-Leu, Ala14-Leu and Tyr16-Leu bonds in insulin B chain

This endopeptidase is present in the venom of the western diamondback rattlesnake ( Crotalus atrox ).

Related Research Articles

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<i>Crotalus</i> Genus of snakes

Crotalus is a genus of venomous pit vipers in the family Viperidae, commonly known as rattlesnakes or rattlers. The genus is found only in the Americas from southern Canada to northern Argentina. The generic name Crotalus is derived from the Greek word κρόταλονkrótalοn, which means "rattle" or "castanet", and refers to the rattle on the end of the tail, which makes this group so distinctive. As of July 2023, 44 to 53 species are recognized as being valid.

<span class="mw-page-title-main">Snake venom</span> Highly modified saliva containing zootoxins

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<span class="mw-page-title-main">Envenomation</span> Process of venom injection

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<i>Crotalus scutulatus</i> Species of snake

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<span class="mw-page-title-main">Eastern diamondback rattlesnake</span> Species of reptile endemic to the southeastern US

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<span class="mw-page-title-main">Myotoxin</span>

Myotoxins are small, basic peptides found in snake venoms and lizard venoms. This involves a non-enzymatic mechanism that leads to severe muscle necrosis. These peptides act very quickly, causing instantaneous paralysis to prevent prey from escaping and eventually death due to diaphragmatic paralysis.

<i>Crotalus ruber</i> Species of snake

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Diamondback rattlesnake may refer to:

<span class="mw-page-title-main">Western diamondback rattlesnake</span> Species of snake

The western diamondback rattlesnake or Texas diamond-back is a rattlesnake species and member of the viper family, found in the southwestern United States and Mexico. Like all other rattlesnakes and all other vipers, it is venomous. It is likely responsible for the majority of snakebite fatalities in northern Mexico and the greatest number of snakebites in the U.S. No subspecies are currently recognized.

Adamalysin is an enzyme. This enzyme catalyses the following chemical reaction

Atrolysin A is an enzyme that is one of six hemorrhagic toxins found in the venom of western diamondback rattlesnake. This endopeptidase has a length of 419 amino acid residues. The metalloproteinase disintegrin-like domain and the cysteine-rich domain of the enzyme are responsible for the enzyme's hemorrhagic effects on organisms via inhibition of platelet aggregation.

Atrolysin B is an enzyme. This enzyme catalyses the following chemical reaction

Atrolysin C is an enzyme. This enzyme catalyses the following chemical reaction

Atroxase is an enzyme. This enzyme catalyses the following chemical reaction

Atrolysin E is an enzyme. This enzyme catalyses the following chemical reaction

Horrilysin is an enzyme. This enzyme catalyses the following chemical reaction

Ruberlysin is an enzyme. This enzyme catalyses the following chemical reaction

References

  1. Nikai T, Mori N, Kishida M, Sugihara H, Tu AT (June 1984). "Isolation and biochemical characterization of hemorrhagic toxin f from the venom of Crotalus atrox (western diamondback rattlesnake)". Archives of Biochemistry and Biophysics. 231 (2): 309–19. doi:10.1016/0003-9861(84)90393-x. PMID   6375570.