Azosemide

Azosemide
Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	none;
Identifiers
	IUPAC name 2-chloro-5-(2H-tetrazol-5-yl)-4-[(thiophen-2-ylmethyl)amino]benzenesulfonamide;
CAS Number	27589-33-9 ;
PubChem CID	2273 ;
DrugBank	DB08961 ;
ChemSpider	2186 ;
UNII	MR40VT1L8Z ;
KEGG	D01323 ;
ChEBI	CHEBI:31248 ;
ChEMBL	ChEMBL1097235 ;
CompTox Dashboard (EPA)	DTXSID7046910 ;
ECHA InfoCard	100.044.121
Chemical and physical data
Formula	C12H11ClN6O2S2
Molar mass	370.83 g·mol−1
3D model (JSmol)	Interactive image ;
	SMILES O=S(=O)(N)c2c(Cl)cc(c(c1n[nH]nn1)c2)NCc3sccc3;
	InChI InChI=1S/C12H11ClN6O2S2/c13-9-5-10(15-6-7-2-1-3-22-7)8(12-16-18-19-17-12)4-11(9)23(14,20)21/h1-5,15H,6H2,(H2,14,20,21)(H,16,17,18,19) ; Key:HMEDEBAJARCKCT-UHFFFAOYSA-N ;
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Last updated December 30, 2025

Azosemide is a high-ceiling loop diuretic agent that was brought to market in 1981 by Boehringer Mannheim.^[1]^[2] As of 2015 it was available as a generic in some Asian countries.^[3]

Azosemide has been found as an adulterant in ketamine.^[4]

References

↑ Sittig M (1988). Pharmaceutical Manufacturing Encyclopedia (PDF). Vol. 1. Noyes Publications. p. 122. ISBN 978-0-8155-1144-1. Archived from the original (PDF) on 2007-10-23.
↑ Bormann D (January 1980). "Diuretics". In Hess HJ (ed.). Annual Reports in Medicinal Chemistry. Vol. 15. Academic Press. pp. 100–105 (101). ISBN 978-0-08-058359-4.
↑ "International listings for azosemide". Drugs.com. Retrieved 23 July 2015.
↑ "Drug Checking Report 2011" (PDF). Energy Control. Archived (PDF) from the original on 20 January 2022. Retrieved 20 January 2022.

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[1] Sittig M (1988). Pharmaceutical Manufacturing Encyclopedia (PDF). Vol. 1. Noyes Publications. p. 122. ISBN 978-0-8155-1144-1. Archived from the original (PDF) on 2007-10-23.

[2] Bormann D (January 1980). "Diuretics". In Hess HJ (ed.). Annual Reports in Medicinal Chemistry. Vol. 15. Academic Press. pp. 100–105 (101). ISBN 978-0-08-058359-4.

[3] "International listings for azosemide". Drugs.com. Retrieved 23 July 2015.

[4] "Drug Checking Report 2011" (PDF). Energy Control. Archived (PDF) from the original on 20 January 2022. Retrieved 20 January 2022.

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