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Bradykinin (BK) (Greek brady-, slow; -kinin, kīn(eîn) to move) is a peptide that promotes inflammation. It causes arterioles to dilate (enlarge) via the release of prostacyclin, nitric oxide, and endothelium-derived hyperpolarizing factor and makes veins constrict, via prostaglandin F2, thereby leading to leakage into capillary beds, due to the increased pressure in the capillaries. Bradykinin consists of nine amino acids, and is a physiologically and pharmacologically active peptide of the kinin group of proteins.
Captopril, sold under the brand name Capoten among others, is an angiotensin-converting enzyme (ACE) inhibitor used for the treatment of hypertension and some types of congestive heart failure. Captopril was the first oral ACE inhibitor found for the treatment of hypertension. It does not cause fatigue as associated with beta-blockers. Due to the adverse drug event of causing hyperkalemia, as seen with most ACE Inhibitors, the medication is usually paired with a diuretic.
Bothrops atrox — also known as the common lancehead, fer-de-lance, barba amarilla and mapepire balsain — is a highly venomous pit viper species found in the tropical lowlands of northern South America east of the Andes, as well as the Caribbean island of Trinidad. No subspecies are currently recognized.
Bothrops is a genus of highly venomous pit vipers endemic to the Neotropics. The generic name, Bothrops, is derived from the Greek words βόθρος, bothros, meaning "pit", and ώπς, ops, meaning "eye" or "face", together an allusion to the heat-sensitive loreal pit organs. Members of this genus are responsible for more human deaths in the Americas than any other group of venomous snakes. Currently, 48 species are recognized.
Sérgio Henrique Ferreira was a Brazilian physician and pharmacologist noted for the discovery of the bradykinin potentiating factor, which led to new and widely used anti-hypertension drugs — the ACE inhibitors.
Wilson Teixeira Beraldo was a Brazilian physician and physiologist, a co-discoverer of bradykinin.
Gastão Rosenfeld, was a Brazilian physician and biomedical scientist, one of the co-discoverers of bradykinin, together with Maurício Rocha e Silva and Wilson Teixeira Beraldo, in 1949.
Bothrops leucurus, commonly known as the whitetail lancehead or the Bahia lancehead, is a species of venomous snake, a pit viper in the family Viperidae. The species is endemic to Brazil. There are no subspecies which are recognized as being valid. A female owned by youtuber Venom Central is over six feet long.
Bothrops jararaca — known as the jararaca or yarara — is a highly venomous pit viper species endemic to South America in southern Brazil, Paraguay, and northern Argentina. The specific name, jararaca, is derived from the Tupi words yarará and ca, which mean "large snake". Within its geographic range, it is often abundant and is an important cause of snakebite. No subspecies are currently recognized.
Batroxobin, also known as reptilase, is a snake venom enzyme with Venombin A activity produced by Bothrops atrox and Bothrops moojeni, venomous species of pit viper found east of the Andes in South America. It is a hemotoxin which acts as a serine protease similarly to thrombin, and has been the subject of many medical studies as a replacement of thrombin. Different enzymes, isolated from different species of Bothrops, have been called batroxobin, but unless stated otherwise, this article covers the batroxobin produced by B. moojeni, as this is the most studied variety.
Bothrops Insularis, commonly known as the Golden Lancehead, is a highly venomous pit viper species found exclusively on the Ilha da Queimada Grande, off the coast of São Paulo state, in Brazil. The species is named for the light yellowish-brown color of its underside and for its head shape that is characteristic of the genus Bothrops. No subspecies of Bothrops insularis are currently recognized. It is one of the most venomous snakes in Latin America.
In enzymology, an L-amino acid oxidase (LAAO) (EC 1.4.3.2) is an enzyme that catalyzes the chemical reaction
Cerastocytin is a thrombin-like serine protease in snake venom.
Bothrops neuwiedi is a highly venomous pit viper species endemic to South America. This relatively small snake has a wide range and is a major source of snakebite in Argentina. It was named after German naturalist Prince Maximilian of Wied-Neuwied (1782-1867), who made important collections in Brazil (1815-1817). Seven subspecies are currently recognized, including the nominate subspecies described here.
Bothrops jararacussu, commonly known in English as the jararacussu, is a highly venomous pit viper species endemic to South America. It is one of the most dreaded snakes in South America and can grow up to 2.2 metres (7.2 ft).
Bothrops moojeni, commonly known in English as the Brazilian lancehead, is a species of venomous snake in the family Viperidae. It is a pit viper endemic to South America.
Teprotide is nonapeptide which has been isolated from the snake Bothrops jararaca. It is an angiotensin converting enzyme inhibitor (ACE inhibitor) which inhibits the conversion of angiotensin I to angiotensin II and may potentiate some of the pharmacological actions of bradykinin. It has a molecular formula of C53H76N14O12 and has been investigated as an antihypertension agent.
Bothropasin is an enzyme. This enzyme catalyses the following chemical reaction
Jararhagin is an enzyme. This enzyme catalyses the following chemical reaction
Venom in medicine is the medicinal use of venoms for therapeutic benefit in treating diseases.
References
- ↑ Tanizaki MM, Zingali RB, Kawazaki H, Imajoh S, Yamazaki S, Suzuki K (1989). "Purification and some characteristics of a zinc metalloprotease from the venom of Bothrops jararaca (jararaca)". Toxicon. 27 (7): 747–55. doi:10.1016/0041-0101(89)90041-x. PMID 2781574.
