Deoxyguanosine triphosphate

Deoxyguanosine triphosphate

Names
IUPAC name 2′-Deoxyguanosine 5′-(tetrahydrogen triphosphate)
Systematic IUPAC name O1-{[(2R,3S,5R)-5-(2-Amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3-hydroxyoxolan-2-yl]methyl} tetrahydrogen triphosphate
Identifiers
CAS Number	2564-35-4  Y
3D model (JSmol)	Interactive image
ChEBI	CHEBI:16497  N
ChEMBL	ChEMBL477486  N
ChemSpider	58613  Y
ECHA InfoCard	100.018.080
PubChem CID	65103
UNII	8C2O37Y44Q  Y
CompTox Dashboard (EPA)	DTXSID60948499 DTXSID50917119, DTXSID60948499
InChI InChI=1S/C10H16N5O13P3/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(26-6)2-25-30(21,22)28-31(23,24)27-29(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,11,13,14,17)/t4-,5+,6+/m0/s1 Y Key: HAAZLUGHYHWQIW-KVQBGUIXSA-N Y
SMILES O=P(O)(O)OP(=O)(O)OP(=O)(O)OC[C@H]3O[C@@H](n1cnc2c1NC(=N/C2=O)\N)C[C@@H]3O
Properties
Chemical formula	C10H16N5O13P3
Molar mass	507.181023
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N  verify  (what is  YN ?) Infobox references

Deoxyguanosine triphosphate ^[1] (dGTP) is a nucleoside triphosphate, and a nucleotide precursor used in cells for DNA synthesis. The substance is used in the polymerase chain reaction technique, in sequencing, and in cloning. It is also the competitor of inhibition onset by acyclovir in the treatment of HSV virus. ^[2]

References

1. Nelson, David L.; Cox, Michael M. (2005). Principles of Biochemistry (4th ed.). New York: W. H. Freeman. ISBN   0-7167-4339-6.
2. Furman PA, Lambe CU, Nelson DJ (July 1982). "Effect of acyclovir on the deoxyribonucleoside triphosphate pool levels in Vero cells infected with herpes simplex virus type 1". Am. J. Med. 73 (1A): 14–7. doi:10.1016/0002-9343(82)90056-0. PMID   6285704.