GEMIN8

GEMIN8
Identifiers
Aliases	GEMIN8 , FAM51A1, gem nuclear organelle associated protein 8
External IDs	OMIM: 300962 MGI: 2384300 HomoloGene: 9882 GeneCards: GEMIN8
Gene location (Human)
Chr.	X chromosome (human)
End	14,029,893 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	164,973,508 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; tibial nerve; ; left lobe of thyroid gland; ; right lobe of thyroid gland; ; left uterine tube; ; canal of the cervix; ; anterior pituitary; ; body of pancreas; ; left coronary artery; ; gastric mucosa;
	Top expressed in
	mirror; ; superior frontal gyrus; ; secondary oocyte; ; proximal tubule; ; ganglionic eminence; ; yolk sac; ; esophagus; ; lip; ; neural tube; ; thymus;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding ;
Cellular component	cytoplasm ; SMN-Sm protein complex ; nucleus ; Gemini of coiled bodies ; nucleoplasm ; cytosol ; SMN complex ;
Biological process	mRNA processing ; RNA splicing ; import into nucleus ; spliceosomal snRNP assembly ;
	Sources:Amigo / QuickGO
Orthologs
	54960
	237221
	ENSG00000046647
	ENSMUSG00000040621
	Q9NWZ8
	Q8BHE1
	NM_001042479 ; NM_001042480 ; NM_017856
	NM_146238 ; NM_001310722 ; NM_001310724
	NP_001035944 ; NP_001035945 ; NP_060326
	NP_001297651 ; NP_001297653 ; NP_666350
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 05, 2023

Gem-associated protein 8 (Gemin-8) is a protein that in humans is encoded by the GEMIN8 gene.^[5]^[6]

Function

Gemin-8 is part of the SMN complex, which is necessary for spliceosomal snRNP assembly in the cytoplasm and pre-mRNA splicing in the nucleus. Gemin-8 binds to both SMN1 and the GEMIN6 / GEMIN7 heterodimer, mediating their interaction. This protein is found in nuclear Gemini of Cajal bodies (gems) and in the cytoplasm. Three transcript variants encoding the same protein have been found for this gene.^[5]

Related Research Articles

Survival of motor neuron or survival motor neuron (SMN) is a protein that in humans is encoded by the SMN1 and SMN2 genes.

Small nuclear ribonucleoprotein Sm D1 is a protein that in humans is encoded by the SNRPD1 gene.

Small nuclear ribonucleoprotein Sm D2 is a protein that in humans is encoded by the SNRPD2 gene. It belongs to the small nuclear ribonucleoprotein core protein family, and is required for pre-mRNA splicing and small nuclear ribonucleoprotein biogenesis. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified.

Small nuclear ribonucleoprotein E is a protein that in humans is encoded by the SNRPE gene.

Small nuclear ribonucleoprotein Sm D3 is a protein that in humans is encoded by the SNRPD3 gene.

Gem-associated protein 2 (GEMIN2), also called survival of motor neuron protein-interacting protein 1 (SIP1), is a protein that in humans is encoded by the GEMIN2 gene.

Probable ATP-dependent RNA helicase DDX20, also known as DEAD-box helicase 20 and gem-associated protein 3 (GEMIN3), is an enzyme that in humans is encoded by the DDX20 gene.

Splicing factor, arginine/serine-rich 9, also known as SFRS9, is a human gene encoding an SR protein involved in splice site selection in alternative splicing.

Small nuclear ribonucleoprotein F is a protein that in humans is encoded by the SNRPF gene.

Serine-threonine kinase receptor-associated protein is an enzyme that in humans is encoded by the STRAP gene.

Small nuclear ribonucleoprotein G is a protein that in humans is encoded by the SNRPG gene.

Survival of motor neuron-related-splicing factor 30 is a protein that in humans is encoded by the SMNDC1 gene.

Syntaxin-binding protein 2 is a protein that in humans is encoded by the STXBP2 gene.

Gem-associated protein 7 is a protein that in humans is encoded by the GEMIN7 gene. The gem-associated proteins are those found in the gems of Cajal bodies.

Gem-associated protein 6 is a protein that in humans is encoded by the GEMIN6 gene. The gem-associated proteins are those found in the gems of Cajal bodies.

Gem-associated protein 4 is a protein that in humans is encoded by the GEMIN4 gene.

CpG-binding protein (CGBP) also known as CXXC-type zinc finger protein 1 (CXXC1) or PHD finger and CXXC domain-containing protein 1 (PCCX1) is a protein that in humans is encoded by the CXXC1 gene.

snRNA-activating protein complex subunit 1 is a protein that in humans is encoded by the SNAPC1 gene.

Amyloid beta A4 precursor protein-binding family B member 3 is a protein that in humans is encoded by the APBB3 gene.

Gem-associated protein 5 is a protein that in humans is encoded by the GEMIN5 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000046647 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040621 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: gem (nuclear organelle) associated protein 8".
↑ Carissimi C, Saieva L, Baccon J, Chiarella P, Maiolica A, Sawyer A, Rappsilber J, Pellizzoni L (March 2006). "Gemin8 is a novel component of the survival motor neuron complex and functions in small nuclear ribonucleoprotein assembly". J. Biol. Chem. 281 (12): 8126–34. doi: 10.1074/jbc.M512243200 . PMID 16434402.

GEMIN8

Contents

Function

Related Research Articles

References

Further reading