GRINL1B

Last updated
glutamate receptor, ionotropic, N-methyl D-aspartate-like 1B
Identifiers
Symbol GRINL1B
Entrez 84534
HUGO 15712
OMIM 608311
UniProt Q9BZD3
Other data
Locus Chr. 4 q12

Glutamate receptor, ionotropic, N-methyl D-aspartate-like 1B, also known as GRINL1B, is a human gene. [1] The protein encoded by this gene is a subunit of the NMDA receptor.

Gene basic physical and functional unit of heredity

In biology, a gene is a sequence of nucleotides in DNA or RNA that codes for a molecule that has a function. During gene expression, the DNA is first copied into RNA. The RNA can be directly functional or be the intermediate template for a protein that performs a function. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic trait. These genes make up different DNA sequences called genotypes. Genotypes along with environmental and developmental factors determine what the phenotypes will be. Most biological traits are under the influence of polygenes as well as gene–environment interactions. Some genetic traits are instantly visible, such as eye color or number of limbs, and some are not, such as blood type, risk for specific diseases, or the thousands of basic biochemical processes that constitute life.

Protein biological molecule consisting of chains of amino acid residues

Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, providing structure to cells and organisms, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific three-dimensional structure that determines its activity.

Protein subunit single protein molecule that assembles with other protein molecules to form a protein complex

In structural biology, a protein subunit is a single protein molecule that assembles with other protein molecules to form a protein complex. Some naturally occurring proteins have a relatively small number of subunits and therefore described as oligomeric, for example hemoglobin or DNA polymerase. Others may consist of a very large number of subunits and therefore described as multimeric, for example microtubules and other cytoskeleton proteins. The subunits of a multimeric protein may be identical, homologous or totally dissimilar and dedicated to disparate tasks.

Related Research Articles

Glutamate receptor

Glutamate receptors are synaptic and non synaptic receptors located primarily on the membranes of neuronal and glial cells. Glutamate is abundant in the human body, but particularly in the nervous system and especially prominent in the human brain where it is the body's most prominent neurotransmitter, the brain's main excitatory neurotransmitter, and also the precursor for GABA, the brain's main inhibitory neurotransmitter. Glutamate receptors are responsible for the glutamate-mediated postsynaptic excitation of neural cells, and are important for neural communication, memory formation, learning, and regulation.

GRIA3 protein-coding gene in the species Homo sapiens

Glutamate receptor 3 is a protein that in humans is encoded by the GRIA3 gene.

Metabotropic glutamate receptor 1 protein-coding gene in the species Homo sapiens

The glutamate receptor, metabotropic 1, also known as GRM1, is a human gene which encodes the metabotropic glutamate receptor 1 (mGluR1) protein.

Metabotropic glutamate receptor 2 protein-coding gene in the species Homo sapiens

Metabotropic glutamate receptor 2 (mGluR2) is a protein that, in humans, is encoded by the GRM2 gene. mGluR2 is a G protein-coupled receptor (GPCR) that couples with the Gi alpha subunit. The receptor functions as an autoreceptor for glutamate, that upon activation, inhibits the emptying of vesicular contents at the presynaptic terminal of glutamatergic neurons.

Metabotropic glutamate receptor 3 protein-coding gene in the species Homo sapiens

Metabotropic glutamate receptor 3 is a protein that in humans is encoded by the GRM3 gene.

Metabotropic glutamate receptor 4 protein-coding gene in the species Homo sapiens

Metabotropic glutamate receptor 4 is a protein that in humans is encoded by the GRM4 gene.

Metabotropic glutamate receptor 5 protein-coding gene in the species Homo sapiens

Metabotropic glutamate receptor 5 is a G protein-coupled receptor that in humans is encoded by the GRM5 gene.

Metabotropic glutamate receptor 7 protein-coding gene in the species Homo sapiens

Metabotropic glutamate receptor 7 is a protein that in humans is encoded by the GRM7 gene.

Metabotropic glutamate receptor 8 protein-coding gene in the species Homo sapiens

Metabotropic glutamate receptor 8 is a protein that in humans is encoded by the GRM8 gene.

GRIN2A protein-coding gene in the species Homo sapiens

Glutamate [NMDA] receptor subunit epsilon-1 is a protein that in humans is encoded by the GRIN2A gene.

GRIN1 protein-coding gene in the species Homo sapiens

Glutamate [NMDA] receptor subunit zeta-1 is a protein that in humans is encoded by the GRIN1 gene.

GRIA1 protein-coding gene in the species Homo sapiens

Glutamate receptor 1 is a protein that in humans is encoded by the GRIA1 gene.

GRIA2 protein-coding gene in the species Homo sapiens

Glutamate ionotropic receptor AMPA type subunit 2 is a protein that in humans is encoded by the GRIA2 gene.

GRIK2 protein-coding gene in the species Homo sapiens

Glutamate ionotropic receptor kainate type subunit 2 is a protein that in humans is encoded by the GRIK2 gene.

GRIK1 protein-coding gene in the species Homo sapiens

Glutamate receptor, ionotropic, kainate 1, also known as GRIK1, is a protein that in humans is encoded by the GRIK1 gene.

GRIN2D protein-coding gene in the species Homo sapiens

Glutamate [NMDA] receptor subunit epsilon-4 is a protein that in humans is encoded by the GRIN2D gene.

GRIA4 protein-coding gene in the species Homo sapiens

Glutamate receptor 4 is a protein that in humans is encoded by the GRIA4 gene.

GRIK3 protein-coding gene in the species Homo sapiens

Glutamate receptor, ionotropic kainate 3 is a protein that in humans is encoded by the GRIK3 gene.

GRINL1A protein-coding gene in the species Homo sapiens

GRINL1A complex locus protein 1 is a protein that in humans is encoded by the GRINL1A gene.

GRID1 protein-coding gene in the species Homo sapiens

Glutamate receptor delta-1 subunit also known as GluD1 or GluRδ1 is a protein that in humans is encoded by the GRID1 gene.

References

  1. Mohan Raj BK, Roginski RS, Finkernagel SW, Sciorra LJ (2001). "Assignment of GRINL1B, a glutamate receptor-like processed gene, to human chromosome 4q12 by in situ hybridization". Cytogenet. Cell Genet. 95 (3-4): 238–9. doi:10.1159/000059353. PMID   12063407.

Medical Subject Headings (MeSH) is a comprehensive controlled vocabulary for the purpose of indexing journal articles and books in the life sciences; it serves as a thesaurus that facilitates searching. Created and updated by the United States National Library of Medicine (NLM), it is used by the MEDLINE/PubMed article database and by NLM's catalog of book holdings. MeSH is also used by ClinicalTrials.gov registry to classify which diseases are studied by trials registered in ClinicalTrials.