GABRP

GABRP
Identifiers
Aliases	GABRP , gamma-aminobutyric acid type A receptor pi subunit, gamma-aminobutyric acid type A receptor subunit pi
External IDs	OMIM: 602729; MGI: 2387597; HomoloGene: 22798; GeneCards: GABRP; OMA:GABRP - orthologs
Gene location (Human) Chr. Chromosome 5 (human) [1] Band 5q35.1 Start 170,763,350 bp [1] End 170,814,047 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 A4 Start 33,500,781 bp [2] End 33,528,959 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in nasal epithelium epithelium of nasopharynx palpebral conjunctiva olfactory zone of nasal mucosa endometrium epithelium of lactiferous gland lactiferous duct mucosa of paranasal sinus amniotic fluid epithelium of bronchus Top expressed in trachea right lung lobe olfactory epithelium genital tubercle abdominal wall gastrula secondary oocyte seminal vesicula lip skin of abdomen More reference expression data BioGPS More reference expression data
Gene ontology Molecular function extracellular ligand-gated ion channel activity chloride channel activity GABA-A receptor activity ion channel activity transmembrane signaling receptor activity Cellular component integral component of membrane cell junction postsynaptic membrane plasma membrane synapse membrane chloride channel complex GABA-A receptor complex integral component of plasma membrane neuron projection Biological process ion transmembrane transport chloride transport ion transport signal transduction chloride transmembrane transport chemical synaptic transmission regulation of membrane potential nervous system process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2568 216643 Ensembl ENSG00000094755 ENSMUSG00000020159 UniProt O00591 Q8QZW7 RefSeq (mRNA) NM_001291985 NM_014211 NM_146017 RefSeq (protein) NP_001278914 NP_055026 NP_666129 Location (UCSC) Chr 5: 170.76 – 170.81 Mb Chr 11: 33.5 – 33.53 Mb PubMed search [3] [4]
Wikidata
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Gamma-aminobutyric acid receptor subunit pi is a protein that in humans is encoded by the GABRP gene. ^{[5] [6]}

The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. The subunit encoded by this gene is expressed in several non-neuronal tissues including the uterus and ovaries. This subunit can assemble with known GABA A receptor subunits, and the presence of this subunit alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone. ^[6]

See also

• GABAA receptor

References

1. GRCh38: Ensembl release 89: ENSG00000094755 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020159 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hedblom E, Kirkness EF (Jul 1997). "A novel class of GABAA receptor subunit in tissues of the reproductive system". J Biol Chem. 272 (24): 15346–15350. doi: 10.1074/jbc.272.24.15346 . PMID   9182563.
6. "Entrez Gene: GABRP gamma-aminobutyric acid (GABA) A receptor, pi".

Further reading

• Mehta AK, Ticku MK (1999). "An update on GABAA receptors". Brain Res. Brain Res. Rev. 29 (2–3): 196–217. doi:10.1016/S0165-0173(98)00052-6. PMID   10209232. S2CID   34393842.
• Zafrakas M, Chorovicer M, Klaman I, et al. (2007). "Systematic characterisation of GABRP expression in sporadic breast cancer and normal breast tissue". Int. J. Cancer. 118 (6): 1453–1459. doi:10.1002/ijc.21517. PMID   16187283. S2CID   21983109.
• Petryshen TL, Middleton FA, Tahl AR, et al. (2006). "Genetic investigation of chromosome 5q GABAA receptor subunit genes in schizophrenia". Mol. Psychiatry. 10 (12): 1074–1088, 1057. doi: 10.1038/sj.mp.4001739 . PMID   16172613.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi: 10.1038/ng1285 . PMID   14702039.
• Galey D, Becker K, Haughey N, et al. (2003). "Differential transcriptional regulation by human immunodeficiency virus type 1 and gp120 in human astrocytes". J. Neurovirol. 9 (3): 358–371. doi:10.1080/13550280390201119. PMID   12775419. S2CID   22016092.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Neelands TR, Macdonald RL (1999). "Incorporation of the pi subunit into functional gamma-aminobutyric Acid(A) receptors". Mol. Pharmacol. 56 (3): 598–610. doi:10.1124/mol.56.3.598. PMID   10462548.
• Taylor PM, Thomas P, Gorrie GH, et al. (1999). "Identification of amino acid residues within GABA(A) receptor beta subunits that mediate both homomeric and heteromeric receptor expression". J. Neurosci. 19 (15): 6360–6371. doi:10.1523/jneurosci.19-15-06360.1999. PMC   6782825 . PMID   10414965.

External links

• GABRP+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.