P2RX6

P2RX6
Identifiers
Aliases	P2RX6 , P2RXL1, P2X6, P2XM, purinergic receptor P2X 6
External IDs	OMIM: 608077 MGI: 1337113 HomoloGene: 3975 GeneCards: P2RX6
Gene location (Human) Chr. Chromosome 22 (human) [1] Band 22q11.21 Start 21,009,808 bp [1] End 21,028,013 bp [1]
Gene location (Mouse) Chr. Chromosome 16 (mouse) [2] Band 16|16 A3 Start 17,379,749 bp [2] End 17,395,664 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle right uterine tube Brodmann area 9 spleen anterior pituitary prefrontal cortex right adrenal gland right coronary artery hypothalamus substantia nigra Top expressed in facial motor nucleus skeletal muscle tissue soleus muscle quadriceps femoris muscle morula temporal muscle masseter muscle anterior horn of spinal cord vastus lateralis muscle intercostal muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function channel activity purinergic nucleotide receptor activity extracellularly ATP-gated cation channel activity ion channel activity identical protein binding ATP binding transmembrane signaling receptor activity ATP-gated ion channel activity Cellular component cytoplasm integral component of membrane membrane integral component of nuclear inner membrane integral component of plasma membrane cell junction plasma membrane postsynapse postsynaptic density neuronal cell body dendritic spine parallel fiber to Purkinje cell synapse glutamatergic synapse integral component of postsynaptic specialization membrane Biological process response to ATP muscle contraction ion transport cation transmembrane transport protein homooligomerization signal transduction blood coagulation purinergic nucleotide receptor signaling pathway excitatory postsynaptic potential protein heterooligomerization cation transport ion transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9127 18440 Ensembl ENSG00000099957 ENSMUSG00000022758 UniProt O15547 O54803 RefSeq (mRNA) NM_001159554 NM_005446 NM_001349874 NM_001349875 NM_001349876 NM_001394691 NM_001394692 NM_001394693 NM_001394694 NM_001394695 NM_001394696 NM_001394697 NM_001159561 NM_011028 RefSeq (protein) NP_001153026 NP_005437 NP_001336803 NP_001336804 NP_001336805 NP_001153033 NP_035158 Location (UCSC) Chr 22: 21.01 – 21.03 Mb Chr 16: 17.38 – 17.4 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

P2X purinoceptor 6 is a protein that in humans is encoded by the P2RX6 gene. ^{[5] [6] [7] [8]}

The protein encoded by this gene belongs to the family of P2X receptors, which are ATP-gated ion channels and mediate rapid and selective permeability to cations. This gene is predominantly expressed in skeletal muscle, and regulated by p53. The encoded protein is associated with VE-cadherin at the adherens junctions of human umbilical vein endothelial cells. ^[8]

See also

• Purinergic receptor

References

1. GRCh38: Ensembl release 89: ENSG00000099957 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022758 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Urano T, Nishimori H, Han H, Furuhata T, Kimura Y, Nakamura Y, Tokino T (Sep 1997). "Cloning of P2XM, a novel human P2X receptor gene regulated by p53". Cancer Res. 57 (15): 3281–7. PMID   9242461.
6. Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al. (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi: 10.1038/990031 . PMID   10591208.
7. Collo G, North RA, Kawashima E, Merlo-Pich E, Neidhart S, Surprenant A, Buell G (Sep 1996). "Cloning OF P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels". J Neurosci. 16 (8): 2495–507. doi:10.1523/JNEUROSCI.16-08-02495.1996. PMC   6578782 . PMID   8786426.
8. "Entrez Gene: P2RXL1 purinergic receptor P2X-like 1, orphan receptor".

Further reading

• Khakh BS, Burnstock G, Kennedy C, et al. (2001). "International union of pharmacology. XXIV. Current status of the nomenclature and properties of P2X receptors and their subunits". Pharmacol. Rev. 53 (1): 107–18. PMID   11171941.
• Soto F, Garcia-Guzman M, Karschin C, Stühmer W (1996). "Cloning and tissue distribution of a novel P2X receptor from rat brain". Biochem. Biophys. Res. Commun. 223 (2): 456–60. doi:10.1006/bbrc.1996.0915. PMID   8670303.
• Glass R, Loesch A, Bodin P, Burnstock G (2002). "P2X4 and P2X6 receptors associate with VE-cadherin in human endothelial cells". Cell. Mol. Life Sci. 59 (5): 870–81. doi:10.1007/s00018-002-8474-y. PMID   12088286. S2CID   16519633.
• Maguire PB, Wynne KJ, Harney DF, et al. (2003). "Identification of the phosphotyrosine proteome from thrombin activated platelets". Proteomics. 2 (6): 642–8. doi: 10.1002/1615-9861(200206)2:6<642::AID-PROT642>3.0.CO;2-I . PMID   12112843. S2CID   22665513.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi: 10.1186/gb-2004-5-10-r84 . PMC   545604 . PMID   15461802.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Barrera NP, Ormond SJ, Henderson RM, et al. (2005). "Atomic force microscopy imaging demonstrates that P2X2 receptors are trimers but that P2X6 receptor subunits do not oligomerize". J. Biol. Chem. 280 (11): 10759–65. doi: 10.1074/jbc.M412265200 . PMID   15657042.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.

External links

• P2RXL1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.