P2RX1

Last updated
P2RX1
Identifiers
Aliases P2RX1 , P2X1, purinergic receptor P2X 1
External IDs OMIM: 600845; MGI: 1098235; HomoloGene: 1921; GeneCards: P2RX1; OMA:P2RX1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002558

NM_008771

RefSeq (protein)

NP_002549

NP_032797

Location (UCSC) Chr 17: 3.9 – 3.92 Mb Chr 11: 72.89 – 72.91 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

P2X purinoceptor 1, also ATP receptor, is a protein that in humans is encoded by the P2RX1 gene. [5]

Contents

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with relatively high calcium permeability. Expressed in smooth muscle and platelets. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle, being responsible, for example, for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. It is possible that the development of selective antagonists for this receptor may provide an effective non-hormonal male contraceptive pill. [6]

See also

Related Research Articles

<span class="mw-page-title-main">Purinergic receptor</span> Family of cell membrane receptors in almost all tissues

Purinergic receptors, also known as purinoceptors, are a family of plasma membrane molecules that are found in almost all mammalian tissues. Within the field of purinergic signalling, these receptors have been implicated in learning and memory, locomotor and feeding behavior, and sleep. More specifically, they are involved in several cellular functions, including proliferation and migration of neural stem cells, vascular reactivity, apoptosis and cytokine secretion. These functions have not been well characterized and the effect of the extracellular microenvironment on their function is also poorly understood.

<span class="mw-page-title-main">P2X purinoreceptor</span>

The P2X receptors, also ATP-gated P2X receptor cation channel family, is a protein family that consists of cation-permeable ligand-gated ion channels that open in response to the binding of extracellular adenosine 5'-triphosphate (ATP). They belong to a larger family of receptors known as the ENaC/P2X superfamily. ENaC and P2X receptors have similar 3-D structures and are homologous. P2X receptors are present in a diverse array of organisms including humans, mouse, rat, rabbit, chicken, zebrafish, bullfrog, fluke, and amoeba.

<span class="mw-page-title-main">Apolipoprotein H</span> Protein-coding gene in humans

β2-glycoprotein 1, also known as beta-2 glycoprotein 1 and Apolipoprotein H (Apo-H), is a 38 kDa multifunctional plasma protein that in humans is encoded by the APOH gene. One of its functions is to bind cardiolipin. When bound, the structure of cardiolipin and β2-GP1 both undergo large changes in structure. Within the structure of Apo-H is a stretch of positively charged amino acids, Lys-Asn-Lys-Glu-Lys-Lys, are involved in phospholipid binding.

<span class="mw-page-title-main">P2RX7</span> Protein-coding gene in the species Homo sapiens

P2X purinoceptor 7 is a protein that in humans is encoded by the P2RX7 gene.

<span class="mw-page-title-main">P2RY1</span> Protein-coding gene in the species Homo sapiens

P2Y purinoceptor 1 is a protein that in humans is encoded by the P2RY1 gene.

<span class="mw-page-title-main">P2RY2</span> Protein-coding gene in the species Homo sapiens

P2Y purinoceptor 2 is a protein that in humans is encoded by the P2RY2 gene.

<span class="mw-page-title-main">F2RL2</span> Protein-coding gene in the species Homo sapiens

Protease activated receptor 3 (PAR-3) also known as coagulation factor II receptor-like 2 (F2RL2) and thrombin receptor-like 2, is a protein that in humans is encoded by the F2RL2 gene.

<span class="mw-page-title-main">P2RY6</span> Protein-coding gene in the species Homo sapiens

P2Y purinoceptor 6 is a protein that in humans is encoded by the P2RY6 gene.

<span class="mw-page-title-main">P2RY4</span> Protein-coding gene in the species Homo sapiens

P2Y purinoceptor 4 is a protein that in humans is encoded by the P2RY4 gene.

<span class="mw-page-title-main">Glycoprotein IX</span> Protein-coding gene in the species Homo sapiens

Glycoprotein IX (platelet) (GP9) also known as CD42a (Cluster of Differentiation 42a), is a human gene.

<span class="mw-page-title-main">GP5 (gene)</span> Protein-coding gene in the species Homo sapiens

Glycoprotein V (platelet) (GP5) also known as CD42d (Cluster of Differentiation 42d), is a human gene.

<span class="mw-page-title-main">Multimerin 1</span> Protein-coding gene in the species Homo sapiens

Multimerin 1, also known as elastin microfibril interfacer 4 (EMILIN-4), is a protein that, in humans, is encoded by the MMRN1 gene.

<span class="mw-page-title-main">P2RX4</span> Protein-coding gene in the species Homo sapiens

P2X purinoceptor 4 is a protein that in humans is encoded by the P2RX4 gene. P2X purinoceptor 4 is a member of the P2X receptor family. P2X receptors are trimeric protein complexes that can be homomeric or heteromeric. These receptors are ligand-gated cation channels that open in response to ATP binding. Each receptor subtype, determined by the subunit composition, varies in its affinity to ATP and desensitization kinetics.

<span class="mw-page-title-main">P2RX5</span> Protein-coding gene in the species Homo sapiens

P2X purinoceptor 5 is a protein in humans that is encoded by the P2RX5 gene.

<span class="mw-page-title-main">SCIN</span> Protein-coding gene in the species Homo sapiens

Scinderin is a protein that in humans is encoded by the SCIN gene. Scinderin is an actin severing protein belonging to the gelsolin superfamily. It was discovered in Dr. Trifaro's laboratory at the University of Ottawa, Canada. Secretory tissues are rich in scinderin. In these tissues scinderin, a calcium dependent protein, regulates cortical actin networks. Normally secretory vesicles are excluded from release sites on the plasma membrane by the presence of a cortical actin filament network. During cell stimulation, calcium channels open allowing calcium ions to enter the secretory cell. Increase in intracellular calcium activates scinderin with the consequent actin filament severing and local dissociation of actin filament networks. This allows the movement of secretory vesicles to release sites on the plasma membrane.

<span class="mw-page-title-main">P2RX2</span> Protein-coding gene in the species Homo sapiens

P2X purinoceptor 2 is a protein that in humans is encoded by the P2RX2 gene.

<span class="mw-page-title-main">P2RX3</span> Protein-coding gene in the species Homo sapiens

P2X purinoceptor 3 is a protein that in humans is encoded by the P2RX3 gene.

<span class="mw-page-title-main">TREML1</span> Protein-coding gene in the species Homo sapiens

Trem-like transcript 1 protein is a protein that in humans is encoded by the TREML1 gene.

<span class="mw-page-title-main">P2RX6</span> Protein-coding gene in the species Homo sapiens

P2X purinoceptor 6 is a protein that in humans is encoded by the P2RX6 gene.

<span class="mw-page-title-main">MYLK2</span> Protein-coding gene in the species Homo sapiens

Myosin light chain kinase 2 also known as MYLK2 is an enzyme which in humans is encoded by the MYLK2 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000108405 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020787 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Valera S, Talabot F, Evans RJ, Gos A, Antonarakis SE, Morris MA, Buell GN (Nov 1996). "Characterization and chromosomal localization of a human P2X receptor from the urinary bladder". Receptors Channels. 3 (4): 283–9. PMID   8834001.
  6. "Entrez Gene: P2RX1 purinergic receptor P2X, ligand-gated ion channel, 1".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.