GRIN3B

GRIN3B
Identifiers
Aliases	GRIN3B , GluN3B, NR3B, glutamate ionotropic receptor NMDA type subunit 3B
External IDs	OMIM: 606651; MGI: 2150393; HomoloGene: 15606; GeneCards: GRIN3B; OMA:GRIN3B - orthologs
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19p13.3 Start 1,000,419 bp [1] End 1,009,732 bp [1]
Gene location (Mouse) Chr. Chromosome 10 (mouse) [2] Band 10|10 C1 Start 79,806,549 bp [2] End 79,813,024 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube olfactory zone of nasal mucosa testicle bronchial epithelial cell stromal cell of endometrium right lung canal of the cervix granulocyte left lobe of thyroid gland right hemisphere of cerebellum Top expressed in lumbar subsegment of spinal cord motor neuron facial motor nucleus spermatid seminiferous tubule ascending aorta aortic valve anterior horn of spinal cord morula embryo More reference expression data BioGPS n/a
Gene ontology Molecular function calcium channel activity glycine binding ion channel activity ionotropic glutamate receptor activity cation channel activity neurotransmitter binding neurotransmitter receptor activity extracellularly glutamate-gated ion channel activity signaling receptor activity Cellular component integral component of membrane postsynaptic membrane membrane plasma membrane synapse cell junction soma NMDA selective glutamate receptor complex postsynapse Biological process regulation of calcium ion transport ion transport ionotropic glutamate receptor signaling pathway protein insertion into membrane calcium ion transmembrane transport cation transmembrane transport ion transmembrane transport excitatory postsynaptic potential signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 116444 170483 Ensembl ENSG00000116032 ENSMUSG00000035745 UniProt O60391 Q5F0I5 Q91ZU9 RefSeq (mRNA) NM_138690 NM_130455 RefSeq (protein) NP_619635 NP_619635.1 NP_569722 Location (UCSC) Chr 19: 1 – 1.01 Mb Chr 10: 79.81 – 79.81 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Glutamate [NMDA] receptor subunit 3B is a protein that in humans is encoded by the GRIN3B gene. ^[5]

See also

• NMDA receptor

References

1. GRCh38: Ensembl release 89: ENSG00000116032 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000035745 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: GRIN3B glutamate receptor, ionotropic, N-methyl-D-aspartate 3B".

Further reading

• Schröder HC, Perovic S, Kavsan V, et al. (1998). "Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death". Neurotoxicology. 19 (4–5): 683–8. PMID   9745929.
• Kornau HC, Schenker LT, Kennedy MB, Seeburg PH (1995). "Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95". Science. 269 (5231): 1737–40. Bibcode:1995Sci...269.1737K. doi:10.1126/science.7569905. PMID   7569905.
• Magnuson DS, Knudsen BE, Geiger JD, et al. (1995). "Human immunodeficiency virus type 1 tat activates non-N-methyl-D-aspartate excitatory amino acid receptors and causes neurotoxicity". Ann. Neurol. 37 (3): 373–80. doi:10.1002/ana.410370314. PMID   7695237. S2CID   24405132.
• Lannuzel A, Lledo PM, Lamghitnia HO, et al. (1996). "HIV-1 envelope proteins gp120 and gp160 potentiate NMDA-induced [Ca2+]i increase, alter [Ca2+]i homeostasis and induce neurotoxicity in human embryonic neurons". Eur. J. Neurosci. 7 (11): 2285–93. doi:10.1111/j.1460-9568.1995.tb00649.x. PMID   8563977. S2CID   27201873.
• Corasaniti MT, Melino G, Navarra M, et al. (1996). "Death of cultured human neuroblastoma cells induced by HIV-1 gp120 is prevented by NMDA receptor antagonists and inhibitors of nitric oxide and cyclooxygenase". Neurodegeneration. 4 (3): 315–21. doi:10.1016/1055-8330(95)90021-7. PMID   8581564.
• Pittaluga A, Pattarini R, Severi P, Raiteri M (1996). "Human brain N-methyl-D-aspartate receptors regulating noradrenaline release are positively modulated by HIV-1 coat protein gp120". AIDS. 10 (5): 463–8. doi:10.1097/00002030-199605000-00003. PMID   8724036. S2CID   1669986.
• Wu P, Price P, Du B, et al. (1996). "Direct cytotoxicity of HIV-1 envelope protein gp120 on human NT neurons". NeuroReport. 7 (5): 1045–9. doi:10.1097/00001756-199604100-00018. PMID   8804048. S2CID   21018147.
• Bennett BA, Rusyniak DE, Hollingsworth CK (1996). "HIV-1 gp120-induced neurotoxicity to midbrain dopamine cultures". Brain Res. 705 (1–2): 168–76. doi:10.1016/0006-8993(95)01166-8. PMID   8821747. S2CID   32822686.
• Toggas SM, Masliah E, Mucke L (1996). "Prevention of HIV-1 gp120-induced neuronal damage in the central nervous system of transgenic mice by the NMDA receptor antagonist memantine". Brain Res. 706 (2): 303–7. doi:10.1016/0006-8993(95)01197-8. PMID   8822372. S2CID   44260060.
• Dreyer EB, Lipton SA (1996). "The coat protein gp120 of HIV-1 inhibits astrocyte uptake of excitatory amino acids via macrophage arachidonic acid". Eur. J. Neurosci. 7 (12): 2502–7. doi:10.1111/j.1460-9568.1995.tb01048.x. PMID   8845955. S2CID   7370984.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Raber J, Toggas SM, Lee S, et al. (1997). "Central nervous system expression of HIV-1 Gp120 activates the hypothalamic-pituitary-adrenal axis: evidence for involvement of NMDA receptors and nitric oxide synthase". Virology. 226 (2): 362–73. doi: 10.1006/viro.1996.0664 . PMID   8955056.
• New DR, Maggirwar SB, Epstein LG, et al. (1998). "HIV-1 Tat induces neuronal death via tumor necrosis factor-alpha and activation of non-N-methyl-D-aspartate receptors by a NFkappaB-independent mechanism". J. Biol. Chem. 273 (28): 17852–8. doi: 10.1074/jbc.273.28.17852 . PMID   9651389.
• Wang P, Barks JD, Silverstein FS (1999). "Tat, a human immunodeficiency virus-1-derived protein, augments excitotoxic hippocampal injury in neonatal rats". Neuroscience. 88 (2): 585–97. doi:10.1016/S0306-4522(98)00242-5. PMID   10197777. S2CID   28927942.
• Howard SA, Nakayama AY, Brooke SM, Sapolsky RM (1999). "Glucocorticoid modulation of gp120-induced effects on calcium-dependent degenerative events in primary hippocampal and cortical cultures". Exp. Neurol. 158 (1): 164–70. doi: 10.1006/exnr.1999.7080 . PMID   10448428. S2CID   7598117.
• Xin KQ, Hamajima K, Hattori S, et al. (1999). "Evidence of HIV type 1 glycoprotein 120 binding to recombinant N-methyl-D-aspartate receptor subunits expressed in a baculovirus system". AIDS Res. Hum. Retroviruses. 15 (16): 1461–7. doi:10.1089/088922299309973. PMID   10555109.
• Haughey NJ, Nath A, Mattson MP, et al. (2001). "HIV-1 Tat through phosphorylation of NMDA receptors potentiates glutamate excitotoxicity". J. Neurochem. 78 (3): 457–67. doi:10.1046/j.1471-4159.2001.00396.x. PMID   11483648. S2CID   25641791.
• Bonavia R, Bajetto A, Barbero S, et al. (2001). "HIV-1 Tat causes apoptotic death and calcium homeostasis alterations in rat neurons". Biochem. Biophys. Res. Commun. 288 (2): 301–8. doi:10.1006/bbrc.2001.5743. PMID   11606043.
• Nishi M, Hinds H, Lu HP, et al. (2002). "Motoneuron-specific expression of NR3B, a novel NMDA-type glutamate receptor subunit that works in a dominant-negative manner". J. Neurosci. 21 (23): RC185. doi:10.1523/JNEUROSCI.21-23-j0003.2001. PMC   6763906 . PMID   11717388.

External links

• GRIN3B+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)