CHRNB2

Last updated
CHRNB2
Protein CHRNB2 PDB 2GVT.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CHRNB2 , EFNL3, nAChRB2, cholinergic receptor nicotinic beta 2 subunit
External IDs OMIM: 118507; MGI: 87891; HomoloGene: 595; GeneCards: CHRNB2; OMA:CHRNB2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000748

NM_009602

RefSeq (protein)

NP_000739

NP_033732

Location (UCSC) Chr 1: 154.57 – 154.58 Mb Chr 3: 89.65 – 89.67 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Neuronal acetylcholine receptor subunit beta-2 is a protein that in humans is encoded by the CHRNB2 gene. [5] [6]

Contents

Neuronal acetylcholine receptors are homo- or heteropentameric complexes composed of homologous alpha and beta subunits. They belong to a superfamily of ligand-gated ion channels which allow the flow of sodium and potassium across the plasma membrane in response to ligands such as acetylcholine and nicotine. This gene encodes one of several beta subunits. Mutations in this gene are associated with autosomal dominant nocturnal frontal lobe epilepsy. [6]

It has been discovered that suppression, rather than stimulation, of B2-containing nAChR currents yields an antidepressant effect. This is believed to explain the significantly increased prevalence of cigarette smoking in depressed individuals and the profound rise in depressive symptoms during abstinence.

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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NicotineDopaminergic WP1602.png go to articlego to articlego to articleGo to articlego to articleGo to articleGo to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articleGo to articlego to articlego to articlego to articlego to articleGo to articleGo to articlego to articleGo to articleGo to articleGo to articlego to articleGo to articleGo to articleGo to articlego to articlego to articlego to articlego to articlego to articlego to articleGo to articlego to articleGo to articleGo to articlego to articlego to articleGo to articlego to articleGo to articleGo to articlego to article
|alt=Nicotine Activity on Dopaminergic Neurons edit]]
Nicotine Activity on Dopaminergic Neurons edit
  1. The interactive pathway map can be edited at WikiPathways: "NicotineDopaminergic_WP1602".

See also

Related Research Articles

<span class="mw-page-title-main">Acetylcholine receptor</span> Integral membrane protein

An acetylcholine receptor or a cholinergic receptor is an integral membrane protein that responds to the binding of acetylcholine, a neurotransmitter.

<span class="mw-page-title-main">Nicotinic acetylcholine receptor</span> Acetylcholine receptors named for their selective binding of nicotine

Nicotinic acetylcholine receptors, or nAChRs, are receptor polypeptides that respond to the neurotransmitter acetylcholine. Nicotinic receptors also respond to drugs such as the agonist nicotine. They are found in the central and peripheral nervous system, muscle, and many other tissues of many organisms. At the neuromuscular junction they are the primary receptor in muscle for motor nerve-muscle communication that controls muscle contraction. In the peripheral nervous system: (1) they transmit outgoing signals from the presynaptic to the postsynaptic cells within the sympathetic and parasympathetic nervous system, and (2) they are the receptors found on skeletal muscle that receive acetylcholine released to signal for muscular contraction. In the immune system, nAChRs regulate inflammatory processes and signal through distinct intracellular pathways. In insects, the cholinergic system is limited to the central nervous system.

Autosomal dominant nocturnal frontal lobe epilepsy is an epileptic disorder that causes frequent violent seizures during sleep. These seizures often involve complex motor movements, such as hand clenching, arm raising/lowering, and knee bending. Vocalizations such as shouting, moaning, or crying are also common. ADNFLE is often misdiagnosed as nightmares. Attacks often occur in clusters and typically first manifest in childhood. There are four known loci for ADNFLE, three with known causative genes. These genes, CHRNA4, CHRNB2, and CHRNA2, encode various nicotinic acetylcholine receptor α and β subunits.

<span class="mw-page-title-main">CHRNA7</span> Protein-coding gene in the species Homo sapiens

Neuronal acetylcholine receptor subunit alpha-7, also known as nAChRα7, is a protein that in humans is encoded by the CHRNA7 gene. The protein encoded by this gene is a subunit of certain nicotinic acetylcholine receptors (nAchR).

<span class="mw-page-title-main">CHRNA4</span> Protein-coding gene in the species Homo sapiens

Neuronal acetylcholine receptor subunit alpha-4, also known as nAChRα4, is a protein that in humans is encoded by the CHRNA4 gene. The protein encoded by this gene is a subunit of certain nicotinic acetylcholine receptors (nAChR). Alpha4-containing nAChRs appear to play a crucial role in the addictive response to nicotine.

<span class="mw-page-title-main">CHRNA3</span> Protein-coding gene in the species Homo sapiens

Neuronal acetylcholine receptor subunit alpha-3, also known as nAChRα3, is a protein that in humans is encoded by the CHRNA3 gene. The protein encoded by this gene is a subunit of certain nicotinic acetylcholine receptors (nAchR). Research with mecamylamine in animals has implicated alpha-3-containing nAChRs in the abusive and addictive properties of ethanol.

<span class="mw-page-title-main">CHRNE</span> Protein-coding gene

Acetylcholine receptor subunit epsilon is a protein that in humans is encoded by the CHRNE gene.

<span class="mw-page-title-main">CHRNA1</span> Protein-coding gene in the species Homo sapiens

Neuronal acetylcholine receptor subunit alpha-1, also known as nAChRα1, is a protein that in humans is encoded by the CHRNA1 gene. The protein encoded by this gene is a subunit of certain nicotinic acetylcholine receptors (nAchR).

<span class="mw-page-title-main">CHRNB4</span> Protein-coding gene in the species Homo sapiens

Neuronal acetylcholine receptor subunit beta-4 is a protein that in humans is encoded by the CHRNB4 gene.

<span class="mw-page-title-main">CACNB1</span> Protein-coding gene in the species Homo sapiens

Voltage-dependent L-type calcium channel subunit beta-1 is a protein that in humans is encoded by the CACNB1 gene.

<span class="mw-page-title-main">CHRNB3</span> Protein-coding gene in the species Homo sapiens

Neuronal acetylcholine receptor subunit beta-3 is a protein that in humans is encoded by the CHRNB3 gene. This gene has been identified as a candidate for predisposition to tobacco dependence.

<span class="mw-page-title-main">CHRNA2</span> Protein-coding gene in the species Homo sapiens

Neuronal acetylcholine receptor subunit alpha-2, also known as nAChRα2, is a protein that in humans is encoded by the CHRNA2 gene. The protein encoded by this gene is a subunit of certain nicotinic acetylcholine receptors (nAchR).

<span class="mw-page-title-main">CHRND</span> Protein-coding gene in the species Homo sapiens

Acetylcholine receptor subunit delta is a protein that in humans is encoded by the CHRND gene.

<span class="mw-page-title-main">CHRNG</span> Protein-coding gene in the species Homo sapiens

Acetylcholine receptor subunit gamma is a protein that in humans is encoded by the CHRNG gene.

<span class="mw-page-title-main">CHRNB1</span> Protein-coding gene in the species Homo sapiens

Acetylcholine receptor subunit beta is a protein that in humans is encoded by the CHRNB1 gene.

<span class="mw-page-title-main">CHRFAM7A</span> Protein-coding gene in the species Homo sapiens

CHRNA7-FAM7A fusion protein is a protein that in humans is encoded by the CHRFAM7A gene.

<span class="mw-page-title-main">CHRNA9</span> Protein-coding gene in the species Homo sapiens

Neuronal acetylcholine receptor subunit alpha-9, also known as nAChRα9, is a protein that in humans is encoded by the CHRNA9 gene. The protein encoded by this gene is a subunit of certain nicotinic acetylcholine receptors (nAchR).

<span class="mw-page-title-main">CHRNA6</span> Protein-coding gene in the species Homo sapiens

Cholinergic receptor, nicotinic, alpha 6, also known as nAChRα6, is a protein that in humans is encoded by the CHRNA6 gene. The CHRNA6 gene codes for the α6 nicotinic receptor subunit that is found in certain types of nicotinic acetylcholine receptors found primarily in the brain. Neural nicotinic acetylcholine receptors containing α6 subunits are expressed on dopamine-releasing neurons in the midbrain, and dopamine release following activation of these neurons is thought to be involved in the addictive properties of nicotine. Due to their selective localisation on dopaminergic neurons, α6-containing nACh receptors have also been suggested as a possible therapeutic target for the treatment of Parkinson's disease. In addition to nicotine, research in animals has implicated alpha-6-containing nAChRs in the abusive and addictive properties of ethanol, with mecamylamine demonstrating a potent ability to block these properties.

<span class="mw-page-title-main">CHRNA10</span> Protein-coding gene in the species Homo sapiens

Neuronal acetylcholine receptor subunit alpha-10, also known as nAChRα10 and cholinergic receptor nicotinic alpha 10, is a protein that in humans is encoded by the CHRNA10 gene. The protein encoded by this gene is a subunit of certain nicotinic acetylcholine receptors (nAchR).

The neuronal acetylcholine receptor subunit alpha-5, or alpha-5 nicotinic acetylcholine receptor(α5 nAChR) also known as the α5 receptor is a type of ligand gated neuronal type subunit of the nicotinic acetylcholine receptor involved in pain regulation encoded in the human by the CHRNA5 gene. This receptor is commonly associated with nicotine addiction, immunotherapy, cancer, pain and attention.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000160716 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027950 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Anand R, Lindstrom J (Sep 1992). "Chromosomal localization of seven neuronal nicotinic acetylcholine receptor subunit genes in humans". Genomics. 13 (4): 962–7. doi:10.1016/0888-7543(92)90008-G. PMID   1505988.
  6. 1 2 "Entrez Gene: CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.