CHRNB4

Last updated
CHRNB4
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CHRNB4 , cholinergic receptor nicotinic beta 4 subunit
External IDs OMIM: 118509; MGI: 87892; HomoloGene: 20196; GeneCards: CHRNB4; OMA:CHRNB4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000750
NM_001256567

NM_148944

RefSeq (protein)

NP_000741
NP_001243496

NP_683746

Location (UCSC) Chr 15: 78.62 – 78.73 Mb Chr 9: 54.94 – 54.96 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Neuronal acetylcholine receptor subunit beta-4 is a protein that in humans is encoded by the CHRNB4 gene. [5] [6]

Contents

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective Wikipedia articles. [§ 1]

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|alt=Nicotine Activity on Chromaffin Cells edit]]
Nicotine Activity on Chromaffin Cells edit
  1. The interactive pathway map can be edited at WikiPathways: "NicotineActivityonChromaffinCells_WP1603".

See also

Related Research Articles

<span class="mw-page-title-main">Nicotinic acetylcholine receptor</span> Acetylcholine receptors named for their selective binding of nicotine

Nicotinic acetylcholine receptors, or nAChRs, are receptor polypeptides that respond to the neurotransmitter acetylcholine. Nicotinic receptors also respond to drugs such as the agonist nicotine. They are found in the central and peripheral nervous system, muscle, and many other tissues of many organisms. At the neuromuscular junction they are the primary receptor in muscle for motor nerve-muscle communication that controls muscle contraction. In the peripheral nervous system: (1) they transmit outgoing signals from the presynaptic to the postsynaptic cells within the sympathetic and parasympathetic nervous system, and (2) they are the receptors found on skeletal muscle that receive acetylcholine released to signal for muscular contraction. In the immune system, nAChRs regulate inflammatory processes and signal through distinct intracellular pathways. In insects, the cholinergic system is limited to the central nervous system.

Autosomal dominant nocturnal frontal lobe epilepsy is an epileptic disorder that causes frequent violent seizures during sleep. These seizures often involve complex motor movements, such as hand clenching, arm raising/lowering, and knee bending. Vocalizations such as shouting, moaning, or crying are also common. ADNFLE is often misdiagnosed as nightmares. Attacks often occur in clusters and typically first manifest in childhood. There are four known loci for ADNFLE, three with known causative genes. These genes, CHRNA4, CHRNB2, and CHRNA2, encode various nicotinic acetylcholine receptor α and β subunits.

Muscarinic acetylcholine receptor M<sub>4</sub> Protein-coding gene

The muscarinic acetylcholine receptor M4, also known as the cholinergic receptor, muscarinic 4 (CHRM4), is a protein that, in humans, is encoded by the CHRM4 gene.

<span class="mw-page-title-main">CHRNA7</span> Protein-coding gene in the species Homo sapiens

Neuronal acetylcholine receptor subunit alpha-7, also known as nAChRα7, is a protein that in humans is encoded by the CHRNA7 gene. The protein encoded by this gene is a subunit of certain nicotinic acetylcholine receptors (nAchR).

<span class="mw-page-title-main">CHRNA4</span> Protein-coding gene in the species Homo sapiens

Neuronal acetylcholine receptor subunit alpha-4, also known as nAChRα4, is a protein that in humans is encoded by the CHRNA4 gene. The protein encoded by this gene is a subunit of certain nicotinic acetylcholine receptors (nAChR). Alpha4-containing nAChRs appear to play a crucial role in the addictive response to nicotine.

<span class="mw-page-title-main">CHRNB2</span> Protein-coding gene in the species Homo sapiens

Neuronal acetylcholine receptor subunit beta-2 is a protein that in humans is encoded by the CHRNB2 gene.

<span class="mw-page-title-main">CHRNA3</span> Protein-coding gene in the species Homo sapiens

Neuronal acetylcholine receptor subunit alpha-3, also known as nAChRα3, is a protein that in humans is encoded by the CHRNA3 gene. The protein encoded by this gene is a subunit of certain nicotinic acetylcholine receptors (nAchR). Research with mecamylamine in animals has implicated alpha-3-containing nAChRs in the abusive and addictive properties of ethanol.

<span class="mw-page-title-main">CHRNE</span> Protein-coding gene

Acetylcholine receptor subunit epsilon is a protein that in humans is encoded by the CHRNE gene.

<span class="mw-page-title-main">CHRNA1</span> Protein-coding gene in the species Homo sapiens

Neuronal acetylcholine receptor subunit alpha-1, also known as nAChRα1, is a protein that in humans is encoded by the CHRNA1 gene. The protein encoded by this gene is a subunit of certain nicotinic acetylcholine receptors (nAchR).

<span class="mw-page-title-main">GABRR1</span> Protein-coding gene in the species Homo sapiens

Gamma-aminobutyric acid receptor subunit rho-1 is a protein that in humans is encoded by the GABRR1 gene.

<span class="mw-page-title-main">CHRNB3</span> Protein-coding gene in the species Homo sapiens

Neuronal acetylcholine receptor subunit beta-3 is a protein that in humans is encoded by the CHRNB3 gene. This gene has been identified as a candidate for predisposition to tobacco dependence.

<span class="mw-page-title-main">CHRNA2</span> Protein-coding gene in the species Homo sapiens

Neuronal acetylcholine receptor subunit alpha-2, also known as nAChRα2, is a protein that in humans is encoded by the CHRNA2 gene. The protein encoded by this gene is a subunit of certain nicotinic acetylcholine receptors (nAchR).

<span class="mw-page-title-main">CHRND</span> Protein-coding gene in the species Homo sapiens

Acetylcholine receptor subunit delta is a protein that in humans is encoded by the CHRND gene.

<span class="mw-page-title-main">CHRNB1</span> Protein-coding gene in the species Homo sapiens

Acetylcholine receptor subunit beta is a protein that in humans is encoded by the CHRNB1 gene.

<span class="mw-page-title-main">CHRFAM7A</span> Protein-coding gene in the species Homo sapiens

CHRNA7-FAM7A fusion protein is a protein that in humans is encoded by the CHRFAM7A gene.

<span class="mw-page-title-main">CHRNA9</span> Protein-coding gene in the species Homo sapiens

Neuronal acetylcholine receptor subunit alpha-9, also known as nAChRα9, is a protein that in humans is encoded by the CHRNA9 gene. The protein encoded by this gene is a subunit of certain nicotinic acetylcholine receptors (nAchR).

<span class="mw-page-title-main">RIC3</span> Protein-coding gene in the species Homo sapiens

RIC-3 also known as resistance to inhibitors of cholinesterase 3 is a chaperone protein that in humans is encoded by the RIC3 gene. The RIC3 gene was first discovered in C. elegans. RIC-3 protein is conserved in most animals and influences the maturation of various ligand gated ion channels including the serotonin 5-HT3 receptor and nicotinic acetylcholine receptors, particularly the homomeric α7 nicotinic receptor. RIC-3 enhances currents generated by these receptors by expediting receptor transport to the cell surface and by increasing receptor number.

<span class="mw-page-title-main">CHRNA6</span> Protein-coding gene in the species Homo sapiens

Cholinergic receptor, nicotinic, alpha 6, also known as nAChRα6, is a protein that in humans is encoded by the CHRNA6 gene. The CHRNA6 gene codes for the α6 nicotinic receptor subunit that is found in certain types of nicotinic acetylcholine receptors found primarily in the brain. Neural nicotinic acetylcholine receptors containing α6 subunits are expressed on dopamine-releasing neurons in the midbrain, and dopamine release following activation of these neurons is thought to be involved in the addictive properties of nicotine. Due to their selective localisation on dopaminergic neurons, α6-containing nACh receptors have also been suggested as a possible therapeutic target for the treatment of Parkinson's disease. In addition to nicotine, research in animals has implicated alpha-6-containing nAChRs in the abusive and addictive properties of ethanol, with mecamylamine demonstrating a potent ability to block these properties.

<span class="mw-page-title-main">CHRNA10</span> Protein-coding gene in the species Homo sapiens

Neuronal acetylcholine receptor subunit alpha-10, also known as nAChRα10 and cholinergic receptor nicotinic alpha 10, is a protein that in humans is encoded by the CHRNA10 gene. The protein encoded by this gene is a subunit of certain nicotinic acetylcholine receptors (nAchR).

The alpha-3 beta-2 nicotinic receptor, also known as the α3β2 receptor, is a type of nicotinic acetylcholine receptor, consisting of α3 and β2 subunits.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000117971 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035200 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Eng CM, Kozak CA, Beaudet AL, Zoghbi HY (Apr 1991). "Mapping of multiple subunits of the neuronal nicotinic acetylcholine receptor to chromosome 15 in man and chromosome 9 in mouse". Genomics. 9 (2): 278–282. doi:10.1016/0888-7543(91)90253-B. PMID   2004777.
  6. "Entrez Gene: CHRNB4 cholinergic receptor, nicotinic, beta 4".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.