GABRR1

GABRR1
Identifiers
Aliases	GABRR1 , gamma-aminobutyric acid type A receptor rho1 subunit, gamma-aminobutyric acid type A receptor subunit rho1
External IDs	OMIM: 137161 MGI: 95625 HomoloGene: 20470 GeneCards: GABRR1
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6q15 Start 89,177,504 bp [1] End 89,231,278 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4 A5|4 14.68 cM Start 33,132,521 bp [2] End 33,163,588 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ascending aorta pancreatic ductal cell tibialis anterior muscle deltoid muscle left coronary artery testicle right coronary artery placenta gastrocnemius muscle lower lobe of lung n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function chloride channel activity extracellular ligand-gated ion channel activity GABA-A receptor activity ion channel activity transmembrane signaling receptor activity ligand-gated ion channel activity involved in regulation of presynaptic membrane potential transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential Cellular component integral component of membrane GABA-A receptor complex postsynaptic membrane membrane plasma membrane synapse integral component of plasma membrane chloride channel complex cell junction neuron projection glutamatergic synapse GABA-ergic synapse Biological process gamma-aminobutyric acid signaling pathway chloride transmembrane transport ion transport chloride transport chemical synaptic transmission ion transmembrane transport signal transduction regulation of membrane potential nervous system process regulation of postsynaptic membrane potential regulation of presynaptic membrane potential Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2569 14408 Ensembl ENSG00000146276 ENSMUSG00000028280 UniProt P24046 P56475 RefSeq (mRNA) NM_001256703 NM_001256704 NM_001267582 NM_002042 NM_008075 RefSeq (protein) NP_001243632 NP_001243633 NP_001254511 NP_002033 NP_032101 Location (UCSC) Chr 6: 89.18 – 89.23 Mb Chr 4: 33.13 – 33.16 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Gamma-aminobutyric acid receptor subunit rho-1 is a protein that in humans is encoded by the GABRR1 gene. ^{[5] [6] [7]}

GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA receptors, which are ligand-gated chloride channels. GABRR1 is a member of the rho subunit family. ^[7]

See also

• GABA_A-ρ receptor

References

1. GRCh38: Ensembl release 89: ENSG00000146276 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028280 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Cutting GR, Lu L, O'Hara BF, Kasch LM, Montrose-Rafizadeh C, Donovan DM, Shimada S, Antonarakis SE, Guggino WB, Uhl GR, et al. (May 1991). "Cloning of the gamma-aminobutyric acid (GABA) rho 1 cDNA: a GABA receptor subunit highly expressed in the retina". Proc Natl Acad Sci U S A. 88 (7): 2673–2677. Bibcode:1991PNAS...88.2673C. doi: 10.1073/pnas.88.7.2673 . PMC   51300 . PMID   1849271.
6. Cutting GR, Curristin S, Zoghbi H, O'Hara B, Seldin MF, Uhl GR (May 1992). "Identification of a putative gamma-aminobutyric acid (GABA) receptor subunit rho2 cDNA and colocalization of the genes encoding rho2 (GABRR2) and rho1 (GABRR1) to human chromosome 6q14-q21 and mouse chromosome 4". Genomics. 12 (4): 801–806. doi:10.1016/0888-7543(92)90312-G. PMID   1315307.
7. "Entrez Gene: GABRR1 gamma-aminobutyric acid (GABA) receptor, rho 1".

Further reading

• Wang TL, Hackam A, Guggino WB, Cutting GR (1995). "A single histidine residue is essential for zinc inhibition of GABA rho 1 receptors". J. Neurosci. 15 (11): 7684–7691. doi:10.1523/jneurosci.15-11-07684.1995. PMC   6578093 . PMID   7472519.
• Hackam AS, Wang TL, Guggino WB, Cutting GR (1997). "The N-terminal domain of human GABA receptor rho1 subunits contains signals for homooligomeric and heterooligomeric interaction". J. Biol. Chem. 272 (21): 13750–13757. doi: 10.1074/jbc.272.21.13750 . PMID   9153229.
• Kusama T, Hatama K, Sakurai M, et al. (1999). "Consensus phosphorylation sites of human GABA(c)/GABArho receptors are not critical for inhibition by protein kinase C activation". Neurosci. Lett. 255 (1): 17–20. doi:10.1016/S0304-3940(98)00696-X. PMID   9839716. S2CID   12933301.
• Hanley JG, Koulen P, Bedford F, et al. (1999). "The protein MAP-1B links GABA(C) receptors to the cytoskeleton at retinal synapses". Nature. 397 (6714): 66–69. Bibcode:1999Natur.397...66H. doi:10.1038/16258. PMID   9892354. S2CID   4421437.
• Bailey ME, Albrecht BE, Johnson KJ, Darlison MG (1999). "Genetic linkage and radiation hybrid mapping of the three human GABA(C) receptor rho subunit genes: GABRR1, GABRR2 and GABRR3". Biochim. Biophys. Acta. 1447 (2–3): 307–312. doi:10.1016/S0167-4781(99)00167-0. PMID   10542332.
• Hanley JG, Jones EM, Moss SJ (2000). "GABA receptor rho1 subunit interacts with a novel splice variant of the glycine transporter, GLYT-1". J. Biol. Chem. 275 (2): 840–846. doi: 10.1074/jbc.275.2.840 . PMID   10625616.
• Filippova N, Sedelnikova A, Zong Y, et al. (2000). "Regulation of recombinant gamma-aminobutyric acid (GABA)(A) and GABA(C) receptors by protein kinase C". Mol. Pharmacol. 57 (5): 847–856. PMID   10779366.
• Billups D, Hanley JG, Orme M, et al. (2001). "GABAC receptor sensitivity is modulated by interaction with MAP1B". J. Neurosci. 20 (23): 8643–8650. doi:10.1523/jneurosci.20-23-08643.2000. PMC   6773065 . PMID   11102469.
• Wang QW, Li ZW, Wang F, Yang JQ (2002). "Modulation by divalent cations of GABA rho 1 receptor from human retina expressed in Xenopus oocytes". Biomed. Environ. Sci. 14 (4): 269–277. PMID   11862606.
• Sedelnikova A, Weiss DS (2002). "Phosphorylation of the recombinant rho1 GABA receptor". Int. J. Dev. Neurosci. 20 (3–5): 237–246. doi:10.1016/S0736-5748(02)00037-0. PMID   12175859. S2CID   54402119.
• Torres VI, Weiss DS (2003). "Identification of a tyrosine in the agonist binding site of the homomeric rho1 gamma-aminobutyric acid (GABA) receptor that, when mutated, produces spontaneous opening". J. Biol. Chem. 277 (46): 43741–43748. doi: 10.1074/jbc.M202007200 . PMID   12226075.
• Croci C, Brändstatter JH, Enz R (2003). "ZIP3, a new splice variant of the PKC-zeta-interacting protein family, binds to GABAC receptors, PKC-zeta, and Kv beta 2". J. Biol. Chem. 278 (8): 6128–6135. doi: 10.1074/jbc.M205162200 . PMID   12431995.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–811. Bibcode:2003Natur.425..805M. doi: 10.1038/nature02055 . PMID   14574404.
• Boué-Grabot E, Emerit MB, Toulmé E, et al. (2004). "Cross-talk and co-trafficking between rho1/GABA receptors and ATP-gated channels". J. Biol. Chem. 279 (8): 6967–6975. doi: 10.1074/jbc.M307772200 . PMID   14660627.
• Martínez-Torres A, Miledi R (2004). "A single amino acid change within the ion-channel domain of the gamma-aminobutyric acid rho1 receptor accelerates desensitization and increases taurine agonism". Arch. Med. Res. 35 (3): 194–198. doi:10.1016/j.arcmed.2003.12.002. PMID   15163459.
• Sedelnikova A, Smith CD, Zakharkin SO, et al. (2005). "Mapping the rho1 GABA(C) receptor agonist binding pocket. Constructing a complete model". J. Biol. Chem. 280 (2): 1535–1542. doi: 10.1074/jbc.M409908200 . PMID   15548535.
• Song XQ, Meng F, Ramsey DJ, et al. (2006). "The GABA rho1 subunit interacts with a cellular retinoic acid binding protein in mammalian retina". Neuroscience. 136 (2): 467–475. doi:10.1016/j.neuroscience.2005.08.018. PMID   16198491. S2CID   37043103.

External links

• GABRR1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.