Genetically modified wheat

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Genetically modified wheat is wheat that has been genetically engineered by the direct manipulation of its genome using biotechnology. As of 2020, no GM wheat is grown commercially, although many field tests have been conducted, with one wheat variety, Bioceres HB4 Wheat, obtaining regulatory approval from the Argentinean government. [1]

Contents

Background

Wheat is a natural hybrid derived from interspecies breeding. It is theorized that wheat's ancestors ( Triticum monococcum, Aegilops speltoides , and Aegilops tauschii , all diploid grasses) hybridized naturally over millennia somewhere in West Asia, to create natural polyploid hybrids, the best known of which are common wheat and durum wheat. [2]

Wheat ( Triticum spp.) is an important domesticated grass used worldwide for food. Its evolution has been influenced by human intervention since the dawn of agriculture. [3]

Interspecies transfer of genes continued to occur in farmers fields during the shift from the Paleolithic diet to the diet adopted by humans following the Neolithic Revolution, or first green revolution. [4] During the transition from a hunter-gatherer social structure to more agrarian societies, humans began to cultivate wheat and further transform it for their needs. Thus, the social and cultural roots of humans and the development of wheat have intertwined since before recorded history.

This process resulted in various wheat species that are grown for specific purposes and climates. In 1873 Wilson [5] cross-pollinated rye and wheat to create triticale. Further transformations using cytogenic hybridization techniques enabled Norman Borlaug, father of the second Green Revolution, [4] to develop wheat species (the semidwarf varieties) that would grow in harsh environments.

Recombinant DNA techniques were developed in the 1980s, work began on creating the first transgenic wheat, coincident with the third Green Revolution. [4] Of the three most important cereals in the world (corn, rice and wheat), wheat was the last to be transformed by transgenic, biolistic methods in 1992, and by Agrobacterium methods in 1997. [6] [7] Unlike corn and rice, its widespread use in the human diet has faced cultural resistance. [8] [9]

Field trials and approvals

As of 2013, 34 field trials of GM wheat have taken place in Europe and 419 have taken place in the US. [10] Modifications tested include those to create resistance to herbicides, create resistance to insects [11] [12] [13] and to fungal pathogens (especially fusarium) and viruses, [14] [15] tolerance to drought and resistance to salinity [16] and heat, [17] increased [18] [19] and decreased [20] content of glutenin, improved nutrition (higher protein content, increased heat stability of the enzyme phytase, increased content of water-soluble dietary fiber, increased lysine content), [21] [22] improved qualities for use as biofuel feedstock, production of drugs via pharming and yield increases. [10] [23] [24] [25] [26] [27]

The Argentinian company Bioceres developed a plant with the HaHB4 gene and it was grown under a wide range of growing conditions that showed better adaptation to drought-prone environments, the most important constraint affecting crop yields worldwide. [28]

Bioceres's HB4

The Argentina-based company Bioceres developed a genetically modified wheat variety with higher yield under drought stress. [29] The variety is named for its expression of a transcription factor, HaHB4, from sunflowers [30] : 8,18  [31] [32] and also known as line IND-00412-7. [33] [34] It was approved by the Argentine government in October 2020, with commercial introduction pending approval of the crop for import by Brazil, Argentina's major wheat export partner. [28]

On 6 May 2022 HB4 was approved by Food Standards Australia New Zealand. [33] [35]

Monsanto's MON 71800

The transgenic wheat that was furthest developed was Monsanto's MON 71800, which is glyphosate-resistant via a CP4/maize EPSPS gene. [36] Monsanto received approval from the FDA for its use in food, but withdrew its EPA application in 2004, so the product was never marketed. It also received approval for use as food in Colombia. [37]

Studies conducted by Monsanto showed that its nutritional components are equivalent to nontransgenic commercially available wheat, [38] and animal studies that have used MON 71800 for feed have confirmed this. [39] Environmental Risk assessments have been conducted by Monsanto, [40] and government regulatory agencies have approved its use in food; [41]

However, farmers were worried about the potential loss of markets in Europe and Asia due to public refusal of the end-product, [42] [43] so Monsanto withdrew its EPA application for Roundup-Ready Wheat. [44]

In 2010 Monsanto's partner in India, Mahyco, announced that it planned to seek approval to market GM wheat in India in the next three to five years. [45]

Escape of GM wheat seed

In 1999 scientists in Thailand claimed they discovered glyphosate-resistant wheat in a grain shipment from the Pacific Northwest of the United States, even though transgenic wheat had never been approved for sale and was only ever grown in test plots. No one could explain how the transgenic wheat got into the food supply. [46]

In May 2013 a strain of genetically-engineered glyphosate-resistant wheat was found on a farm in Oregon. Extensive testing confirmed the wheat as a variety – MON71800. [47] The wheat had been developed by Monsanto but never been approved or marketed after the company had tested it between 1998 and 2005. The unexplained presence of this type of wheat presents a problem to wheat growers when buyers demand GMO-free wheat. [48] Japan subsequently suspended import of soft white wheat from the United States. [49] A Kansas farmer sued Monsanto over the release, saying it had caused the price of wheat grown in the US to fall. [50] Monsanto suggested that the presence of this wheat was likely an act of sabotage. [51] On Jun 14, 2013, the USDA announced: "As of today, USDA has neither found nor been informed of anything that would indicate that this incident amounts to more than a single isolated incident in a single field on a single farm. All information collected so far shows no indication of the presence of GE wheat in commerce." [52] As of August 30, 2013, while the source of the GM wheat remained unknown, Japan, South Korea and Taiwan had all resumed placing orders, and the disruption of the export market was minimal. [53]

The investigation was closed in 2014 after the USDA Animal and Plant Health Inspection Service (APHIS) had exhausted all leads but had not found any evidence that the wheat had entered commercial supply.

In 2019, the USDA announced that genetically modified wheat plants engineered to resist Roundup were detected in an unplanted field in Washington state. [54]

Regulation

The regulation of genetic engineering concerns the approaches taken by governments to assess and manage the risks associated with the development and release of genetically modified crops. There are differences in the regulation of GM crops between countries, with some of the most marked differences occurring between the USA and Europe. Regulation varies in a given country depending on the intended use of the products of the genetic engineering. For example, a crop not intended for food use is generally not reviewed by authorities responsible for food safety.

Related Research Articles

<span class="mw-page-title-main">Genetically modified maize</span> Genetically modified crop

Genetically modified maize (corn) is a genetically modified crop. Specific maize strains have been genetically engineered to express agriculturally-desirable traits, including resistance to pests and to herbicides. Maize strains with both traits are now in use in multiple countries. GM maize has also caused controversy with respect to possible health effects, impact on other insects and impact on other plants via gene flow. One strain, called Starlink, was approved only for animal feed in the US but was found in food, leading to a series of recalls starting in 2000.

The Monsanto Company was an American agrochemical and agricultural biotechnology corporation founded in 1901 and headquartered in Creve Coeur, Missouri. Monsanto's best known product is Roundup, a glyphosate-based herbicide, developed in the 1970s. Later, the company became a major producer of genetically engineered crops. In 2018, the company ranked 199th on the Fortune 500 of the largest United States corporations by revenue.

<span class="mw-page-title-main">Genetically modified food</span> Foods produced from organisms that have had changes introduced into their DNA

Genetically modified foods, also known as genetically engineered foods, or bioengineered foods are foods produced from organisms that have had changes introduced into their DNA using the methods of genetic engineering. Genetic engineering techniques allow for the introduction of new traits as well as greater control over traits when compared to previous methods, such as selective breeding and mutation breeding.

<span class="mw-page-title-main">Genetically modified crops</span> Plants used in agriculture

Genetically modified crops are plants used in agriculture, the DNA of which has been modified using genetic engineering methods. Plant genomes can be engineered by physical methods or by use of Agrobacterium for the delivery of sequences hosted in T-DNA binary vectors. In most cases, the aim is to introduce a new trait to the plant which does not occur naturally in the species. Examples in food crops include resistance to certain pests, diseases, environmental conditions, reduction of spoilage, resistance to chemical treatments, or improving the nutrient profile of the crop. Examples in non-food crops include production of pharmaceutical agents, biofuels, and other industrially useful goods, as well as for bioremediation.

Since the advent of genetic engineering in the 1970s, concerns have been raised about the dangers of the technology. Laws, regulations, and treaties were created in the years following to contain genetically modified organisms and prevent their escape. Nevertheless, there are several examples of failure to keep GM crops separate from conventional ones.

<span class="mw-page-title-main">Genetically modified food controversies</span> Controversies over GMO food

Genetically modified food controversies are disputes over the use of foods and other goods derived from genetically modified crops instead of conventional crops, and other uses of genetic engineering in food production. The disputes involve consumers, farmers, biotechnology companies, governmental regulators, non-governmental organizations, and scientists. The key areas of controversy related to genetically modified food are whether such food should be labeled, the role of government regulators, the objectivity of scientific research and publication, the effect of genetically modified crops on health and the environment, the effect on pesticide resistance, the impact of such crops for farmers, and the role of the crops in feeding the world population. In addition, products derived from GMO organisms play a role in the production of ethanol fuels and pharmaceuticals.

Roundup Ready is the Monsanto trademark for its patented line of genetically modified crop seeds that are resistant to its glyphosate-based herbicide, Roundup.

The MON 810 corn is a genetically modified maize used around the world. It is a Zea mays line known as YieldGard from the company Monsanto. This plant is a genetically modified organism (GMO) designed to combat crop loss due to insects. There is an inserted gene in the DNA of MON 810 which allows the plant to make a protein that harms insects that try to eat it. The inserted gene is from the Bacillus thuringiensis which produces the Bt protein that is poisonous to insects in the order Lepidoptera, including the European Corn Borer.

The United States is the largest grower of commercial crops that have been genetically engineered in the world, but not without domestic and international opposition.

<span class="mw-page-title-main">Genetically modified soybean</span> Soybean that has had DNA introduced into it using genetic engineering techniques

A genetically modified soybean is a soybean that has had DNA introduced into it using genetic engineering techniques. In 1996, the first genetically modified soybean was introduced to the U.S. by Monsanto. In 2014, 90.7 million hectares of GM soybeans were planted worldwide, this is almost 82% of the total soybeans cultivation area.

Genetically modified canola is a genetically modified crop. The first strain, Roundup Ready canola, was developed by Monsanto for tolerance to glyphosate, the active ingredient in the commonly used herbicide Roundup.

The Center for Food Safety (CFS) is a 501c3, U.S. non-profit advocacy organization, based in Washington, D.C. It maintains an office in San Francisco, California. The executive director is Andrew Kimbrell, an attorney. Its stated mission is to protect human health and the environment, focusing on food production technologies such as genetically modified plants and organisms (GMOs). It was founded in 1997.

Genetic engineering in the European Union has varying degrees of regulation.

<span class="mw-page-title-main">Séralini affair</span> Retracted study led by Gilles-Éric Séralini

The Séralini affair was the controversy surrounding the publication, retraction, and republication of a journal article by French molecular biologist Gilles-Éric Séralini. First published by Food and Chemical Toxicology in September 2012, the article presented a two-year feeding study in rats, and reported an increase in tumors among rats fed genetically modified corn and the herbicide RoundUp. Scientists and regulatory agencies subsequently concluded that the study's design was flawed and its findings unsubstantiated. A chief criticism was that each part of the study had too few rats to obtain statistically useful data, particularly because the strain of rat used, Sprague Dawley, develops tumors at a high rate over its lifetime.

<span class="mw-page-title-main">March Against Monsanto</span> International protest movement

The March Against Monsanto is an international grassroots movement and protest against Monsanto, a producer of genetically modified organisms (GMOs) and Roundup, a glyphosate-based herbicide. The movement was founded by Tami Canal in response to the failure of California Proposition 37, a ballot initiative which would have required labeling food products made from GMOs. Advocates support mandatory labeling laws for food made from GMOs.

A genetically modified sugar beet is a sugar beet that has been genetically engineered by the direct modification of its genome using biotechnology. Commercialized GM sugar beets make use of a glyphosate-resistance modification developed by Monsanto and KWS Saat. These glyphosate-resistant beets, also called 'Roundup Ready' sugar beets, were developed by 2000, but not commercialized until 2007. For international trade, sugar beets have a Maximum Residue Limit of glyphosate of 15 mg/Kg at harvest. As of 2016, GMO sugar beets are grown in the United States and Canada. In the United States, they play an important role in domestic sugar production. Studies have concluded the sugar from glyphosate-resistant sugar beets is molecularly identical to and so has the same nutritional value as sugar from conventional (non-GMO) sugar beets.

Genetically modified (GM) crops have been commercially cultivated in four African countries; South Africa, Burkina Faso, Egypt and Sudan. Beginning in 1998, South Africa is the major grower of GM crops, with Burkina Faso and Egypt starting in 2008. Sudan grew GM cotton in 2012. Other countries, with the aid of international governments and foundation, are conducting trials and research on crops important for Africa. Crops under research for use in Africa include cotton, maize, cassava, cowpea, sorgum, potato, banana, sweet potato, sugar cane, coconut, squash and grape. As well as disease, insect and virus resistance some of the research projects focus on traits particularly crucial for Africa like drought resistance and biofortification.

Brazil and Argentina are the 2nd and 3rd largest producers of genetically modified food behind the United States.

HB4 wheat is a type of wheat that has been genetically modified by introducing sunflower genes, with the objective of improving crop productivity. Wheat, along with corn and soybeans, constitute the basis of world food, and different scientific research was focused on improving its productivity. The improvements in food production achieved in the 90's agricultural production could equal the food demand of the world population, thanks to different technological improvements.

References

  1. ↑ "Exclusive: Argentina first country to approve GMO wheat". Reuters. 2020-10-07. Retrieved 2022-05-27.
  2. ↑ Wrigley, Corke & Walker 2004 , p. 330
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  4. 1 2 3 Nelson 2001 , p. 144
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  6. ↑ Jones & Shewry 2009 , table on p.4
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  10. 1 2 Staff, GMO Compass. Last updated June 2010. GM Wheat Archived 2017-02-24 at the Wayback Machine
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  13. ↑ Picket, John (2 May 2012) Respect the need to experiment with GM crops New scientist, Retrieved 2 May 2012
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  18. ↑ Hamaker 2008 , p. 466
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  26. ↑ Bailey, Ronald. "Anti-Biotech Superstition Being Beaten Back in Europe?" Reason, 21 July 2011.
  27. ↑ Avise 2004 , p. 62
  28. 1 2 "Exclusive: Argentina first country to approve GMO wheat". Reuters. 8 October 2020.
  29. ↑ Gilbert, Jonathan (13 March 2019). "Drought-Stricken Wheat Belts Offered a Thorny Solution From Argentina". Bloomberg.com. Bloomberg . Retrieved 9 June 2019.
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  33. 1 2 "HB4® Wheat Gets Approval in Australia and New Zealand". ISAAA (International Service for the Acquisition of Agri-biotech Applications) Crop Biotech Update. 2022-05-11. Retrieved 2022-05-17.
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  35. ↑ "Genetically-Modified Wheat Earns Nod from Top Grower Australia". Bloomberg . 2022-05-06. Retrieved 2022-05-17.
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  38. ↑ Obert J.C., et al. (2004) "The composition of grain and forage from glyphosate tolerant wheat MON 71800 is equivalent to that of conventional wheat (Triticum aestivum L.)." J.Agric Food Chem. 2004 Mar 10:53(5):1375-84
  39. ↑ Kan, C. A. and Hartnell, G. F. (2004) "Evaluation of broiler performance when fed Roundup-Ready wheat (event MON 71800), control, and commercial wheat varieties" Poultry Science, Vol 83, Issue 8, 1325–1334
  40. ↑ "The Center for Environmental Risk Assessment database". Cera-gmc.org. 30 June 2005. Archived from the original on July 25, 2011. Retrieved 13 January 2012.{{cite web}}: CS1 maint: unfit URL (link)
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  42. ↑ "Network of Concerned Farmers, Submission on APPLICATION A524 FOOD DERIVED FROM HERBICIDE-TOLERANT WHEAT MON 71800". Non-gm-farmers.com. Archived from the original on 10 January 2012. Retrieved 13 January 2012.
  43. ↑ Michael Hopkin for Nature News. 11 May 2004 Monsanto scrubs transgenic wheat: Farmers' fears spell doom for project worth millions
  44. ↑ "WestBred Sale Could Change Wheat Industry". Foodmanufacturing.com. 25 September 2009. Archived from the original on 6 October 2011. Retrieved 13 January 2012.
  45. ↑ Thomas Kutty Abraham (6 August 2010). "Monsanto-backed Mahyco Plans India's First GM Wheat". Bloomberg Businessweek . Archived from the original on May 21, 2011. Retrieved 3 October 2010.
  46. ↑ Hannelore Sudermann for the Spokesman Review (Spokane, WA). October 14, 1999 Genetically Altered Wheat Flagged – Thailand Detects Shipment Not Cleared for Commercial Sales
  47. ↑ Staff (June 14, 2013). "Genetically modified wheat investigation". Oregon Department of Agriculture. Archived from the original on 2018-12-07. Retrieved 2013-06-24.
  48. ↑ "Unapproved Monsanto GMO Wheat Found in Oregon". CNBC. Reuters. 2013-05-29. Retrieved 2013-05-30.
  49. ↑ Allison M (June 1, 2013). "Japan's wheat-import suspension worries state growers". Seattle Times . Archived from the original on 2013-09-22.
  50. ↑ Hegeman, Roxana (2013-06-04). "Monsanto sued over genetically modified wheat". USA Today. AP. Retrieved 2013-12-24.
  51. ↑ Ian Berry (June 21, 2013). "Monsanto Says Sabotage Is Likely in Wheat Case". Wall Street Journal . Retrieved June 23, 2013.
  52. ↑ Staff, Food Safety News . June 17, 2013. GMO Wheat Found in Oregon Was Isolated Incident, Says USDA
  53. ↑ Associated Press. August 30, 2013. Source of GMO wheat in Oregon remains mystery Archived 2013-09-14 at the Wayback Machine
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Bibliography

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