Horrilysin

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Horrilysin
Identifiers
EC no. 3.4.24.47
CAS no. 84056-81-5
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Horrilysin (EC 3.4.24.47, Crotalus horridus metalloendopeptidase, hemorrhagic proteinase IV, Crotalus horridus horridus venom hemorrhagic proteinase) is an enzyme. [1] [2] This enzyme catalyses the following chemical reaction

Cleavage of only the single bond Ala14-Leu in the insulin B chain, Ser12-Leu in the A chain, and Ile-Gly, Pro-Ala, and Ser-Trp in melittin

This endopeptidase is present in the venom of the timber rattlesnake (Crotalus horridus horridus)

Related Research Articles

<i>Crotalus</i> Genus of snakes

Crotalus is a genus of venomous pit vipers in the family Viperidae, commonly known as rattlesnakes or rattlers. The genus is found only in the Americas from southern Canada to northern Argentina. The generic name Crotalus is derived from the Greek word κρόταλονkrótalοn, which means "rattle" or "castanet", and refers to the rattle on the end of the tail, which makes this group so distinctive. As of July 2023, 44 to 53 species are recognized as being valid.

<span class="mw-page-title-main">Timber rattlesnake</span> Species of reptile

The timber rattlesnake, canebrake rattlesnake, or banded rattlesnake is a species of pit viper endemic to eastern North America. Like all other pit vipers, it is venomous, with a very toxic bite. C. horridus is the only rattlesnake species in most of the populous Northeastern United States and is second only to its relatives to the west, the prairie rattlesnake, as the most northerly distributed venomous snake in North America. No subspecies are currently recognized.

<span class="mw-page-title-main">Disintegrin</span> Proteins from viper venom inhibiting platelets aggregation

Disintegrins are a family of small proteins from viper venoms that function as potent inhibitors of both platelet aggregation and integrin-dependent cell adhesion.

<span class="mw-page-title-main">Eastern diamondback rattlesnake</span> Species of reptile endemic to the southeastern US

The eastern diamondback rattlesnake is a species of pit viper in the family Viperidae. The species is endemic to the Southeastern United States. It is one of the heaviest venomous snakes in the Americas and the largest rattlesnake. No subspecies are recognized.

<span class="mw-page-title-main">Western diamondback rattlesnake</span> Species of snake

The western diamondback rattlesnake or Texas diamond-back is a rattlesnake species and member of the viper family, found in the southwestern United States and Mexico. Like all other rattlesnakes and all other vipers, it is venomous. It is likely responsible for the majority of snakebite fatalities in northern Mexico and the greatest number of snakebites in the U.S. No subspecies are currently recognized.

<span class="mw-page-title-main">Pepsin A</span>

Pepsin A is an enzyme. This enzyme catalyses the following chemical reaction

Adamalysin is an enzyme. This enzyme catalyses the following chemical reaction

Endothiapepsin is an enzyme. This enzyme catalyses the following chemical reaction

Atrolysin A is an enzyme that is one of six hemorrhagic toxins found in the venom of western diamondback rattlesnake. This endopeptidase has a length of 419 amino acid residues. The metalloproteinase disintegrin-like domain and the cysteine-rich domain of the enzyme are responsible for the enzyme's hemorrhagic effects on organisms via inhibition of platelet aggregation.

Atrolysin B is an enzyme. This enzyme catalyses the following chemical reaction

Atrolysin C is an enzyme. This enzyme catalyses the following chemical reaction

Atroxase is an enzyme. This enzyme catalyses the following chemical reaction

Atrolysin E is an enzyme. This enzyme catalyses the following chemical reaction

Atrolysin F is an enzyme. This enzyme catalyses the following chemical reaction

Ruberlysin is an enzyme. This enzyme catalyses the following chemical reaction

Trimerelysin I is an enzyme. This enzyme catalyses the following chemical reaction

Trimerelysin II is an enzyme. This enzyme catalyses the following chemical reaction

Fibrolase is an enzyme. This enzyme catalyses the following chemical reaction

Jararhagin is an enzyme. This enzyme catalyses the following chemical reaction

References

  1. Civello DJ, Duong HL, Geren CR (February 1983). "Isolation and characterization of a hemorrhagic proteinase from timber rattlesnake venom". Biochemistry. 22 (4): 749–55. doi:10.1021/bi00273a007. PMID   6340728.
  2. Civello DJ, Moran JB, Geren CR (February 1983). "Substrate specificity of a hemorrhagic proteinase from timber rattlesnake venom". Biochemistry. 22 (4): 755–62. doi:10.1021/bi00273a008. PMID   6340729.