Insulysin

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Insulysin
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EC no. 3.4.24.56
CAS no. 9013-83-6
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Insulysin (EC 3.4.24.56) (Also called insulinase, insulin-degrading enzyme , insulin protease, insulin proteinase, insulin-degrading neutral proteinase, insulin-specific protease, insulin-glucagon protease, metalloinsulinase, IDE) is an enzyme. [1] [2] [3] [4] [5] This enzyme catalyses the degradation reaction of insulin, glucagon and other polypeptides.

Contents

This cytosolic enzyme is present in mammals and in many arthropods such as the fly Drosophila melanogaster .

See also

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References

  1. Duckworth WC (August 1988). "Insulin degradation: mechanisms, products, and significance". Endocrine Reviews. 9 (3): 319–45. doi:10.1210/edrv-9-3-319. PMID   3061785.
  2. Affholter JA, Hsieh CL, Francke U, Roth RA (August 1990). "Insulin-degrading enzyme: stable expression of the human complementary DNA, characterization of its protein product, and chromosomal mapping of the human and mouse genes". Molecular Endocrinology. 4 (8): 1125–35. doi: 10.1210/mend-4-8-1125 . PMID   2293021.
  3. Duckworth WC, Hamel FG, Bennett R, Ryan MP, Roth RA (February 1990). "Human red blood cell insulin-degrading enzyme and rat skeletal muscle insulin protease share antigenic sites and generate identical products from insulin". The Journal of Biological Chemistry. 265 (5): 2984–7. PMID   1689296.
  4. Kuo WL, Gehm BD, Rosner MR (October 1990). "Cloning and expression of the cDNA for a Drosophila insulin-degrading enzyme". Molecular Endocrinology. 4 (10): 1580–91. doi: 10.1210/mend-4-10-1580 . PMID   2126597.
  5. Ding L, Becker AB, Suzuki A, Roth RA (February 1992). "Comparison of the enzymatic and biochemical properties of human insulin-degrading enzyme and Escherichia coli protease III". The Journal of Biological Chemistry. 267 (4): 2414–20. PMID   1733942.

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