John Desmond Bernal

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John Desmond Bernal [1]

FRS
John Desmond Bernal.jpg
Born(1901-05-10)10 May 1901
Died15 September 1971(1971-09-15) (aged 70)
London, England
Resting placeBattersea Cemetery,
Morden (unmarked) [2]
ResidenceEngland
Education Bedford School
Alma mater University of Cambridge
Known for Bernal chart
Bernal stacking
Science
politics
Awards Royal Medal 1945,
Guthrie lecture 1947,
Stalin Peace Prize 1953,
Grotius Gold Medal 1959,
Bakerian Lecture 1962
Fellow of the Royal Society [3]
Scientific career
Fields X-ray crystallography
Institutions Birkbeck College, University of London
Doctoral advisor William Henry Bragg [ citation needed ]
Doctoral students

John Desmond Bernal FRS [3] ( /bərˈnɑːl/ ; 10 May 1901 – 15 September 1971) was an Irish scientist who pioneered the use of X-ray crystallography in molecular biology. He published extensively on the history of science. In addition, Bernal was a political supporter of communism and wrote popular books on science and society.

Fellow of the Royal Society Elected Fellow of the Royal Society, including Honorary, Foreign and Royal Fellows

Fellowship of the Royal Society is an award granted to individuals that the Royal Society of London judges to have made a 'substantial contribution to the improvement of natural knowledge, including mathematics, engineering science and medical science'.

X-ray crystallography Technique used in studying crystal structure

X-ray crystallography (XRC) is a technique used for determining the atomic and molecular structure of a crystal, in which the crystalline structure causes a beam of incident X-rays to diffract into many specific directions. By measuring the angles and intensities of these diffracted beams, a crystallographer can produce a three-dimensional picture of the density of electrons within the crystal. From this electron density, the mean positions of the atoms in the crystal can be determined, as well as their chemical bonds, their crystallographic disorder, and various other information.

Molecular biology branch of biology that deals with the molecular basis of biological activity

Molecular biology is a branch of biology that concerns the molecular basis of biological activity between biomolecules in the various systems of a cell, including the interactions between DNA, RNA, proteins and their biosynthesis, as well as the regulation of these interactions. Writing in Nature in 1961, William Astbury described molecular biology as:

...not so much a technique as an approach, an approach from the viewpoint of the so-called basic sciences with the leading idea of searching below the large-scale manifestations of classical biology for the corresponding molecular plan. It is concerned particularly with the forms of biological molecules and [...] is predominantly three-dimensional and structural – which does not mean, however, that it is merely a refinement of morphology. It must at the same time inquire into genesis and function.

Contents

Education and early life

His family was Irish, of mixed Italian and Spanish/Portuguese [5] Sephardic Jewish origin on his father's side (his grandfather Jacob Genese, properly Ginesi, had adopted the family name Bernal of his paternal grandmother around 1837). [3] His father Samuel Bernal had been raised as a Catholic in Limerick and after graduating from Albert Agricultural College spent 14 years in Australia before returning to Tipperary to buy a farm, Brookwatson, near Nenagh where Bernal was brought up. His American mother, née Elizabeth Miller, whose mother was from Antrim, was a graduate of Stanford University and a journalist and had converted to Catholicism. [6] [7]

Limerick City in Munster, Ireland

Limerick is a city in County Limerick, Ireland. It is located in the Mid-West Region and is also part of the province of Munster. Limerick City and County Council is the local authority for the city. The city lies on the River Shannon, with the historic core of the city located on King's Island, which is bounded by the Shannon and the Abbey River. Limerick is also located at the head of the Shannon Estuary where the river widens before it flows into the Atlantic Ocean. With a population of 94,192, Limerick is the third most populous urban area in the state, and the fourth most populous city on the island of Ireland.

County Tipperary County in the Republic of Ireland

County Tipperary is a county in Ireland. It is located in the province of Munster. The county is named after the town of Tipperary, and was established in the early thirteenth century, shortly after the Norman invasion of Ireland. The population of the county was 159,553 at the 2016 census. The largest towns are Clonmel, Nenagh and Thurles.

Nenagh Town in Munster, Ireland

Nenagh meaning “The Fair of Ormond” or simply "The Fair", is the county town and second largest town in County Tipperary in Ireland. Nenagh used to be a market town, and the site of the East Munster Ormond Fair.

Bernal was educated in England, first for one term at Stonyhurst College which he hated. Because of this he was moved to Bedford School at the age of thirteen. There, according to Goldsmith, for five years from 1914 to 1919 he found it "extremely unpleasant" and most of his fellow students "bored him" though his younger brother Kevin who was also there was "some consolation" [8] and Brown claims "he seemed to adjust easily to life" there. [9] In 1919, he went to Emmanuel College, Cambridge with a scholarship. [10] [11]

Stonyhurst College coeducational Roman Catholic independent school in Lancashire, England

Stonyhurst College is a coeducational Roman Catholic independent school, adhering to the Jesuit tradition, on the Stonyhurst Estate, Lancashire, England. It occupies a Grade I listed building. The school has been fully co-educational since 1999.

Bedford School day and boarding IB World School for boys in Bedford, England

Bedford School is an HMC independent school for boys located in the county town of Bedford in England. Founded in 1552, it is the oldest of four independent schools in Bedford run by the Harpur Trust.

Emmanuel College, Cambridge college of the University of Cambridge

Emmanuel College is a constituent college of the University of Cambridge. The college was founded in 1584 by Sir Walter Mildmay, Chancellor of the Exchequer to Elizabeth I.

At Cambridge, Bernal read both mathematics and science for a Bachelor of Arts degree in 1922, which he followed by another year of natural sciences. He taught himself the theory of space groups, including the quaternion method; this became the mathematical basis of a lengthy paper on crystal structure for which he won a joint prize with Ronald G.W. Norrish in his third year. Whilst at Cambridge, he also became known as "Sage", a nickname given to him about 1920 by a young woman working in Charles Kay Ogden's Bookshop at the corner of Bridge Street. [12]

A Bachelor of Arts is a bachelor's degree awarded for an undergraduate course or program in either the liberal arts, sciences, or both. Bachelor of Arts programs generally take three to four years depending on the country, institution, and specific specializations, majors, or minors. The word baccalaureus should not be confused with baccalaureatus, which refers to the one- to two-year postgraduate Bachelor of Arts with Honors degree in some countries.

Natural science branch of science about the natural world

Natural science is a branch of science concerned with the description, prediction, and understanding of natural phenomena, based on empirical evidence from observation and experimentation. Mechanisms such as peer review and repeatability of findings are used to try to ensure the validity of scientific advances.

Space group symmetry group of a configuration in space

In mathematics, physics and chemistry, a space group is the symmetry group of a configuration in space, usually in three dimensions. In three dimensions, there are 219 distinct types, or 230 if chiral copies are considered distinct. Space groups are also studied in dimensions other than 3 where they are sometimes called Bieberbach groups, and are discrete cocompact groups of isometries of an oriented Euclidean space.

Career and research

After graduation, Bernal began research under William Henry Bragg at the Davy Faraday Laboratory at the Royal Institution [13] in London. In 1924 he determined the structure of graphite (the Bernal stacking describes the registry of two graphite planes) and also did work on the crystal structure of bronze. [13] His strength was in analysis as much as experimental method, and his mathematical and practical treatment of determining crystal structure was widely studied, though he also developed an X-ray spectro-goniometer. [14]

William Henry Bragg British scientist

Sir William Henry Bragg was a British physicist, chemist, mathematician, and active sportsman who uniquely shared a Nobel Prize with his son Lawrence Bragg – the 1915 Nobel Prize in Physics: "for their services in the analysis of crystal structure by means of X-rays". The mineral Braggite is named after him and his son. He was knighted in 1920.

Royal Institution scientific education and research organisation based in London

The Royal Institution of Great Britain is an organisation devoted to scientific education and research, based in London. It was founded in 1799 by the leading British scientists of the age, including Henry Cavendish and its first president, George Finch, the 9th Earl of Winchilsea. Its foundational principles were diffusing the knowledge of, and facilitating the general introduction of, useful mechanical inventions and improvements, as well as enhancing the application of science to the common purposes of life.

Graphite allotrope of carbon, mineral, substance

Graphite, archaically referred to as plumbago, is a crystalline form of the element carbon with its atoms arranged in a hexagonal structure. It occurs naturally in this form and is the most stable form of carbon under standard conditions. Under high pressures and temperatures it converts to diamond. Graphite is used in pencils and lubricants. Its high conductivity makes it useful in electronic products such as electrodes, batteries, and solar panels.

In 1927, he was appointed as the first lecturer in Structural Crystallography at Cambridge, becoming the assistant director of the Cavendish Laboratory in 1934. Here he started applying his crystallographic techniques to organic molecules, starting with oestrin and sterol compounds including cholesterol in 1929, forcing a radical change of thinking among sterol chemists. [15] While at Cambridge, he analysed vitamin B1 (1933), pepsin (1934), vitamin D2 (1935), the sterols (1936), and the tobacco mosaic virus (1937). [13]

Cavendish Laboratory Physics laboratory

The Cavendish Laboratory is the Department of Physics at the University of Cambridge, and is part of the School of Physical Sciences. The laboratory was opened in 1874 on the New Museums Site as a laboratory for experimental physics and is named after the British chemist and physicist Henry Cavendish. The laboratory has had a huge influence on research in the disciplines of physics and biology.

Cholesterol sterol biosynthesized by all animal cells which is an essential structural component of all animal cell membranes

Cholesterol is an organic molecule. It is a sterol, a type of lipid. Cholesterol is biosynthesized by all animal cells and is an essential structural component of animal cell membranes.

Pepsin Enzyme

Pepsin is an endopeptidase that breaks down proteins into smaller peptides. It is produced in the stomach and is one of the main digestive enzymes in the digestive systems of humans and many other animals, where it helps digest the proteins in food. Pepsin has a three-dimensional structure, of which one or more polypeptide chains twist and fold, bringing together a small number of amino acids to form the active site, or the location on the enzyme where the substrate binds and the reaction takes place. Pepsin is an aspartic protease, using a catalytic aspartate in its active site.

He also worked on the structure of liquid water, showing the boomerang shape of its molecule (1933). It was in Bernal's research group where, following a year working with Tiny Powell at Oxford, Dorothy Hodgkin continued her early research career. [4] Together, in 1934, they took the first X-ray photographs of hydrated protein crystals using the trick of bathing the crystals in their mother liquor, giving one of the first glimpses of the world of molecular structure that underlies living things. [16] Max Perutz arrived as a student from Vienna in 1936 and started the work on haemoglobin that would occupy him most of his career.

However, Bernal was refused fellowships at Emmanuel and Christ's and tenure by Ernest Rutherford, who disliked him, [17] and in 1937, Bernal became Professor of Physics at Birkbeck College, University of London, a department which had been brought to the first rank by Patrick Blackett. The same year he was elected as a Fellow of the Royal Society. [3] After World War II he established Birkbeck's Biomolecular Research Laboratory in two Georgian houses in Torrington Square with 15 researchers. Aaron Klug worked on ribonuclease whilst Andrew Booth developed some of the earliest computers to help with the computation. Rosalind Franklin joined from King's College and did pioneering work on viruses until her early death in 1957.

His Guthrie lecture of 1947 concentrated on proteins as the basis of life, but it was Perutz, still at Cambridge, who picked up Linus Pauling's leads. In the early 1960s, Bernal returned to the subject of the origin of life — analysing meteorites for evidence of complex molecules — and to the topic of the structure of liquids, which he talked about in his Bakerian lecture in 1962. [18]

Ministry of Home Security

In the early thirties Bernal had been arguing for peace, but the Spanish Civil War changed that. With the outbreak of World War II in 1939, Bernal joined the Ministry of Home Security, where he brought in Solly Zuckerman to carry out the first proper analyses of the effects of enemy bombing and of explosions on animals and people. Their subsequent analysis of the effects of bombs on Birmingham and Hull showed that city bombing produced little disruption and production was only affected by direct hits on factories. A supper of scientists in Soho generated a multi-author book Science in War produced in a month by Allen Lane, one of the guests, arguing that science should be applied in every part of the war effort. [19]

From 1942 he and Zuckerman served as scientific advisers to Lord Louis Mountbatten, the Chief of Combined Operations. [13] Bernal was able to argue on both sides of Project Habbakuk, Pyke's proposal to build huge aircraft landing platforms in the North Atlantic made of ice. He rescued Max Perutz from internment, getting him to perform experiments on ice related to Habbakuk in a meat store freezer below Smithfield Meat Market. [20] This project indirectly marked his divergence from Zuckerman, when he was recalled from a joint tour of the Middle East investigating the cooperation of army and air force, although the tour established Zuckerman's reputation as a military scientist. [21]

Operation Overlord and D-Day

After the disaster of the Dieppe raid, Bernal was determined that these mistakes not be repeated in Operation Overlord. He demonstrated the advantages of an artificial harbour to the participants of the Quebec Conference in 1943, as the only British scientist present. But his main contribution to the Normandy landings was the detailed mapping of the beaches which had to be done without attracting any German attention. [22] His knowledge of the area stemmed from research in English libraries, personal experience (he had visited Arromanches on previous holidays) and aerial surveys. [23]

At Bernal's memorial service, Zuckerman downplayed Bernal's part in the Normandy landings, saying he was not cleared for the highest levels of security. [24] Given Bernal's Marxist and pro-Soviet sympathies it is perhaps remarkable that there has never been any suggestion that he fed any information in that direction. [25] But Brown provides evidence [26] [27] of Bernal's contributions to the preparation and the success of the invasion.

After assisting in the preparations for D-Day with work on the structure of the proposed landing sites and the bocage countryside beyond, Bernal landed, according to C. P. Snow, at Normandy on the afternoon of D-Day+1 in the uniform of an Instructor-Lieutenant RN to record the effectiveness of the plans. He also assisted boats floundering on the rocks using his knowledge of the area but said: "I committed the frightful solecism of not knowing which was port and which side was starboard". [28]

Publications

His 1929 work The World, the Flesh and the Devil has been called "the most brilliant attempt at scientific prediction ever made" by Arthur C. Clarke. [29] It is famous for having been the first to propose the so-called Bernal sphere, a type of space habitat intended for permanent residence. The second chapter explores radical changes to human bodies and intelligence and the third discusses the impact of these on society.

In The Social Function of Science (1939) he argued that science was not an individual pursuit of abstract knowledge and that the support of research and development should be dramatically increased. Eugene Garfield, originator of the Science Citation Index, said "his idea of a centralized reprint center was in my thoughts when I first proposed the as yet nonexistent SCI in Science in 1955." [30]

Science in History (1954) is a monumental four-volume attempt to analyse the interaction between science and society. The Origin of Life (1967) gives the current ideas from Oparin and Haldane onwards.

Other publications include

  • Bernal, J. D. (1926). "On the Interpretation of X-Ray, Single Crystal, Rotation Photographs". Proceedings of the Royal Society of London. 113 (763): 117–160. Bibcode:1926RSPSA.113..117B. doi:10.1098/rspa.1926.0143.
  • The World, the Flesh & the Devil: An Enquiry into the Future of the Three Enemies of the Rational Soul (1929) Jonathan Cape. Scholar Robert Scholes calls this a "book of breathtaking scientific speculation" that "is probably the single most influential source of science fiction ideas." [31]
  • Aspects of Dialectical Materialism (1934) with E. F. Carritt, Ralph Fox, Hyman Levy, John Macmurray, R. Page Arnot
  • The Social Function of Science (1939) Faber & Faber
  • Science and the Humanities (1946) pamphlet
  • The Freedom of Necessity (1949)
  • The Physical Basis of Life (1951)
  • Marx and Science (1952) Marxism Today Series No. 9
  • Science and Industry in the Nineteenth Century (1953) Routledge.
  • Bernal, J. D. (1953). "Stalin as Scientist". Modern Quarterly. 8 (3).
  • Science in History (1954) four volumes in later editions, The Emergence of Science; The Scientific and Industrial Revolutions; The Natural Sciences in Our Time; The Social Sciences: Conclusions. Faber & Faber
  • World without War (1958)
  • A Prospect of Peace (1960)
  • Need There Be Need? (1960) pamphlet
  • The Origin of Life (1967)
  • Emergence of Science (1971)
  • The Extension of Man. A History of Physics before 1900 (1972) M.I.T. Press also as A History of Classical Physics from Antiquity to the Quantum
  • On History (1980) with Fernand Braudel
  • Engels and Science, Labour Monthly pamphlet
  • After Twenty-five Years
  • Peace to the World, British Peace Committee pamphlet
  • Bernal, J. D. (1968). "The relation of microscopic structure to molecular structure". Quarterly Reviews of Biophysics. 1 (1): 81–87. doi:10.1017/S0033583500000469. PMID   4885734.
  • Bernal, J. D. (1965). "The structure of water and its biological implications". Symposia of the Society for Experimental Biology. 19: 17–32. PMID   5849048.
  • Bernal, J. D. (1953). "The Use of Fourier Transforms in Protein Crystal Analysis". Proceedings of the Royal Society B: Biological Sciences. 141 (902): 71–85. Bibcode:1953RSPSB.141...71B. doi:10.1098/rspb.1953.0022.
  • Bernal, J. D. (1952). "Phase Determination in the X-Ray Diffraction Patterns of Complex Crystals and its Application to Protein Structure". Nature. 169 (4311): 1007–1008. Bibcode:1952Natur.169.1007B. doi:10.1038/1691007a0. PMID   14947858.

Political activism

Although raised as a Catholic in his childhood, Bernal became a socialist in Cambridge as a result of a long night arguing with a friend. He also became an atheist. [32] According to one reviewer, "This conversion, as complete as St. Paul's on the road to Damascus, goes some way to account for, but not excuse, Bernal's blind allegiance for the rest of his life, to the Soviet Union." [33] [34] He joined the Communist Party of Great Britain (CPGB) in 1923. [35] His membership evidently lapsed when he returned to Cambridge in 1927 and was not renewed until 1933, [36] and he may have lost his card again shortly after this. [35]

Bernal became a prominent intellectual in political life, particularly in the 1930s. He attended the famous 1931 meeting on the history of science, where he met the Soviets Nikolai Bukharin, and Boris Hessen who gave an influential Marxist account of the work of Isaac Newton. This meeting fundamentally changed his world-view and he maintained sympathy for the Soviet Union and Joseph Stalin. In 1939, Bernal published The Social Function of Science, probably the earliest text on the sociology of science.

After World War II, although Bernal had been involved in evaluating the effects of atomic attacks against the Soviet Union, [36] he supported the World Congress of Intellectuals for Peace organised in communist Poland in 1948. Afterwards, he wrote a letter to the New Statesman warning that the US was preparing "a war for complete world domination". [37] Consequently, when Bernal was invited to a world peace conference in New York in February 1949, his visa was refused. But he was allowed into France in April for the World Congress of the Partisans of Peace, with Frédéric Joliot-Curie as president and Bernal as vice-president. The following year the organisation changed its name to the World Peace Council.

On 20 September 1949, after his return from giving a speech strongly critical of western countries at a peace conference in Moscow, the Evening Star newspaper of Ipswich published an interview with Bernal in which he endorsed Soviet agriculture, the "proletarian science" of Trofim Lysenko. [23] The Lysenko affair had erupted in August 1948 when Stalin authorised Lysenko's theory of plant genetics as official Soviet orthodoxy, and refused any deviation. Bernal and the whole British scientific left were damaged by his support for Lysenko's theory, even after many scientists abandoned their sympathy for the Soviet Union.

Under pressure from the burgeoning Cold War, the president of British Royal Society had resigned from the Soviet Academy of Sciences in November 1948. [38] In November 1949, the British Association for the Advancement of Science removed Bernal from membership of its council. [39] Membership in UK radical science groups quickly declined. Unlike some of his socialist colleagues, Bernal persisted in defending the Soviet position on Lysenko. He publicly refused to accept the gaping fissures that the dispute revealed between the study of natural science and dialectical materialism. [40]

In November 1950, Pablo Picasso, a fellow communist, en route to a Soviet-sponsored [41] World Peace Congress in Sheffield created a mural in Bernal's flat at the top of No. 22 Torrington Square. [42] In 2007 this became part of the Wellcome Trust's collection [43] [44] for £250,000.

Throughout the 1950s, Bernal maintained a faith in the Soviet Union as a vehicle for the creation of a socialist scientific utopia. In 1953 he was awarded the Stalin Peace Prize. [45] From 1959 to 1965 he was president of the World Peace Council.

Awards and honours

Bernal was awarded the Royal Medal in 1945 [46] , the Guthrie lecture in 1947, [47] [48] the Stalin Peace Prize in 1953, [45] the Grotius Gold Medal in 1959 [34] and the Bakerian Lecture in 1962. [18] [49]

Bernal was elected a Fellow of the Royal Society in 1937. [3] A fictional portrait of Bernal appears in the novel The Search, an early work of his friend C. P. Snow. He was also said[ by whom? ] to be the inspiration for the character Tengal in The Holiday by Stevie Smith. The Bernal Lecture and its successor the Wilkins-Bernal-Medawar Lecture Medal and Lecture were named in his honour. [48]

Legacy

The Bernal Building at the University of Limerick wwas named in his honour.

Personal life

Bernal had two children (Mike, 1926–2016 and Egan, b.1930) [2] with his wife Agnes Eileen Sprague (referred to as Eileen), [50] who was a secretary. He married Sprague on 21 June 1922, the day after having been awarded his BA degree. Bernal was 21, Sprague 23. Sprague was described as an active socialist and their marriage as 'open' which they both lived up to 'with great gusto'. [51]

In the early 1930s he had a brief intimate relationship with chemist Dorothy Hodgkin, whose scientific research work he mentored. [4] [52] He had a long-term relationship with the artist Margaret Gardiner. Their son Martin Bernal (1937–2013) [53] was a professor in the Department of Government at Cornell University and author of the controversial Afrocentric work Black Athena . [54] [55] Margaret referred to herself as "Mrs. Bernal", though the two never married. Eileen is mentioned as his widow in 1990. [50]

He also had a child (Jane, b.1953) with Margot Heinemann. [2]

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References

  1. Images of Bernal at the National Portrait Gallery
  2. 1 2 3 Goldsmith 1980, p. 238
  3. 1 2 3 4 5 Hodgkin, D. M. C. (1980). "John Desmond Bernal. 10 May 1901-15 September 1971". Biographical Memoirs of Fellows of the Royal Society . 26: 16–84. doi:10.1098/rsbm.1980.0002.
  4. 1 2 3 Hodgkin, Dorothy Mary Crowfoot (1937). X-ray crystallography and the chemistry of the sterols. lib.cam.ac.uk (PhD thesis). University of Cambridge. EThOS   uk.bl.ethos.727110.
  5. Bevis Marks Records, Vols 1–6 of the Spanish and Portuguese Jewish Congregation, London; Miriam Rodrigues Pereira, ed.
  6. Brown, Andrew (2005). J. D. Bernal: the sage of science. Oxford [Oxfordshire]: Oxford University Press. ISBN   0-19-851544-8.
  7. Brown 2005 , pp. 1–3
  8. Goldsmith 1980 , p. 24
  9. Brown 2005 , p. 9
  10. Goldsmith 1980 , p. 26
  11. Boylan, Henry (1998). A Dictionary of Irish Biography, 3rd Edition. Dublin: Gill and MacMillan. p. 25. ISBN   0-7171-2945-4.
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