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Formula | C31H24O12 |
Molar mass | 588.521 g·mol−1 |
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Kolaflavanone is a biflavonoid isolated from the nuts of Garcinia kola . It has been reported to exhibit antioxidant, neuroprotective, antidiabetic, and reproductive protective effects in experimental models.
It shows antioxidant activity, including protection against gamma-radiation in animal models. Studies in Drosophila melanogaster suggest potential anti-Parkinson effects as well as increased longevity. [1]
Kolaflavanone (as part of the biflavonoid fraction kolaviron) has also been investigated for protective effects against reproductive toxicity. Findings from animal studies suggest amelioration of chemically or radiation-induced reproductive damage, although vitamin E has shown similar protective effects. [2] [3] [4] In vitro studies indicate that kolaflavanone may protect neuronal cell lines from toxic insults induced by the herbicide atrazine, a known endocrine-disrupting chemical. [5] [6] Kolaflavanone has further been reported to exert antidiabetic effects in experimental models. [7]
Extraction methods for biflavonoids from Garcinia kola nuts, including kolaflavanone, have been described in patent literature. [8]