Lactaldehyde reductase

lactaldehyde reductase
Identifiers
EC no.	1.1.1.77
CAS no.	37250-15-0
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, lactaldehyde reductase (EC 1.1.1.77) is an enzyme that catalyzes two chemical reactions

(R)-propane-1,2-diol

+ NAD⁺

 

 

 

H⁺

 

H⁺

 

(R)-lactaldehyde

+ NADH

 

(S)-propane-1,2-diol

+ NAD⁺

 

 

 

H⁺

 

H⁺

 

(S)-lactaldehyde

+ NADH

 

Each individual reaction is stereospecific so that when the substrate of the enzyme is (R)-propane-1,2-diol it produces (R)-lactaldehyde but the enantiomeric substrate (S)-propane-1,2-diol gives only (S)-lactaldehyde. The enzyme's cofactor is nicotinamide adenine dinucleotide (NAD⁺), which is converted to NADH, and also releases a proton. ^{[1] [2]}

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is (R)[or (S)]-propane-1,2-diol:NAD⁺ oxidoreductase. Other names in common use include propanediol:nicotinamide adenine dinucleotide (NAD⁺) oxidoreductase, and L-lactaldehyde:propanediol oxidoreductase. This enzyme participates in pyruvate metabolism and glyoxylate and dicarboxylate metabolism.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1RRM, 2BI4, and 2BL4.

References

1. Enzyme 1.1.1.77 at KEGG Pathway Database.
2. Ting SM, Sellinger OZ, Miller ON (1964). "The metabolism of lactaldehyde. VI. The reduction of D- and L-lactaldehyde in rat liver". Biochim. Biophys. Acta. 89: 217–225. doi:10.1016/0926-6569(64)90210-x. PMID   14203169.