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Chylomicrons, also known as ultra low-density lipoproteins (ULDL), are lipoprotein particles that consist of triglycerides (85–92%), phospholipids (6–12%), cholesterol (1–3%), and proteins (1–2%). They transport dietary lipids from the intestines to other locations in the body. ULDLs are one of the five major groups of lipoproteins that enable fats and cholesterol to move within the water-based solution of the bloodstream. A protein specific to chylomicrons is ApoB48.
Hypertriglyceridemia is the presence of high amounts of triglycerides in the blood. Triglycerides are the most abundant fatty molecule in most organisms. Hypertriglyceridemia occurs in various physiologic conditions and in various diseases, and high triglyceride levels are associated with atherosclerosis, even in the absence of hypercholesterolemia and predispose to cardiovascular disease.
Macular degeneration, also known as age-related macular degeneration, is a medical condition which may result in blurred or no vision in the center of the visual field. Early on there are often no symptoms. Over time, however, some people experience a gradual worsening of vision that may affect one or both eyes. While it does not result in complete blindness, loss of central vision can make it hard to recognize faces, drive, read, or perform other activities of daily life. Visual hallucinations may also occur.
Hyperlipidemia is abnormally elevated levels of any or all lipids or lipoproteins in the blood. The term hyperlipidemia refers to the laboratory finding itself and is also used as an umbrella term covering any of various acquired or genetic disorders that result in that finding. Hyperlipidemia represents a subset of dyslipidemia and a superset of hypercholesterolemia. Hyperlipidemia is usually chronic and requires ongoing medication to control blood lipid levels.
Electroretinography measures the electrical responses of various cell types in the retina, including the photoreceptors, inner retinal cells, and the ganglion cells. Electrodes are placed on the surface of the cornea or on the skin beneath the eye to measure retinal responses. Retinal pigment epithelium (RPE) responses are measured with an EOG test with skin-contact electrodes placed near the canthi. During a recording, the patient's eyes are exposed to standardized stimuli and the resulting signal is displayed showing the time course of the signal's amplitude (voltage). Signals are very small, and typically are measured in microvolts or nanovolts. The ERG is composed of electrical potentials contributed by different cell types within the retina, and the stimulus conditions can elicit stronger response from certain components.
Vitelliform macular dystrophy is an irregular autosomal dominant eye disorder which can cause progressive vision loss. This disorder affects the retina, specifically cells in a small area near the center of the retina called the macula. The macula is responsible for sharp central vision, which is needed for detailed tasks such as reading, driving, and recognizing faces. The condition is characterized by yellow, slightly elevated, round structures similar to the yolk of an egg.
The fundus of the eye is the interior surface of the eye opposite the lens and includes the retina, optic disc, macula, fovea, and posterior pole. The fundus can be examined by ophthalmoscopy and/or fundus photography.
Oguchi disease is an autosomal recessive form of congenital stationary night blindness associated with fundus discoloration and abnormally slow dark adaptation.
Lipoprotein lipase deficiency is a genetic disorder in which a person has a defective gene for lipoprotein lipase, which leads to very high triglycerides, which in turn causes stomach pain and deposits of fat under the skin, and which can lead to problems with the pancreas and liver, which in turn can lead to diabetes. The disorder only occurs if a child acquires the defective gene from both parents. It is managed by restricting fat in diet to less than 20 g/day.
Charcot–Bouchard aneurysms are aneurysms of the brain vasculature which occur in small blood vessels. Charcot–Bouchard aneurysms are most often located in the lenticulostriate vessels of the basal ganglia and are associated with chronic hypertension. Charcot–Bouchard aneurysms are a common cause of cerebral hemorrhage.
Blurred vision is an ocular symptom where vision becomes less precise and there is added difficulty to resolve fine details.
Familial hypertriglyceridemia is a genetic disorder characterized by the liver overproducing very-low-density lipoproteins (VLDL). As a result, an affected individual will have an excessive number of VLDL and triglycerides on a lipid profile. This genetic disorder usually follows an autosomal dominant inheritance pattern. The disorder presents clinically in patients with mild to moderate elevations in triglyceride levels. Familial hypertriglyceridemia is typically associated with other co-morbid conditions such as hypertension, obesity, and hyperglycemia. Individuals with the disorder are mostly heterozygous in an inactivating mutation of the gene encoding for lipoprotein lipase (LPL). This sole mutation can markedly elevate serum triglyceride levels. However, when combined with other medications or pathologies it can further elevate serum triglyceride levels to pathologic levels. Substantial increases in serum triglyceride levels can lead to certain clinical signs and the development of acute pancreatitis.
Bonnet–Dechaume–Blanc syndrome, also known as Wyburn-Mason syndrome, is a rare congenital disorder characterized by arteriovenous malformations of the brain, retina or facial nevi. The syndrome has a number of possible symptoms and can, more rarely, affect the skin, bones, kidneys, muscles, and gastrointestinal tract. When the syndrome affects the brain, people can experience severe headaches, seizures, acute stroke, meningism, and progressive neurological deficits due to acute or chronic ischaemia caused by arteriovenous shunting.
Branch retinal vein occlusion is a common retinal vascular disease of the elderly. It is caused by the occlusion of one of the branches of central retinal vein.
Chloroquine retinopathy is a form of toxic retinopathy caused by the drugs chloroquine or hydroxychloroquine, which are sometimes used in the treatment of autoimmune disorders such as rheumatoid arthritis and systemic lupus erythematosus. This eye toxicity limits long-term use of the drugs.
Autoimmune retinopathy (AIR) is a rare disease in which the patient's immune system attacks proteins in the retina, leading to loss of eyesight. The disease is poorly understood, but may be the result of cancer or cancer chemotherapy. The disease is an autoimmune condition characterized by vision loss, blind spots, and visual field abnormalities. It can be divided into cancer-associated retinopathy (CAR) and melanoma-associated retinopathy (MAR). The condition is associated with retinal degeneration caused by autoimmune antibodies recognizing retinal proteins as antigens and targeting them. AIR's prevalence is extremely rare, with CAR being more common than MAR. It is more commonly diagnosed in females in the age range of 50–60.
Photic retinopathy is damage to the eye's retina, particularly the macula, from prolonged exposure to solar radiation or other bright light, e.g., lasers or arc welders. The term includes solar, laser, and welder's retinopathy and is synonymous with retinal phototoxicity. It usually occurs due to staring at the Sun, watching a solar eclipse, or viewing an ultraviolet, Illuminant D65, or other bright light.[1]
Photostress recovery time (PSRT) is the time taken for visual acuity to return to normal levels after the retina has been bleached by a bright light source. Photostress recovery time measurement procedure is known as photostress test. Normal recovery time is about 15–30 seconds.
Sickle cell retinopathy can be defined as retinal changes due to blood vessel damage in the eye of a person with a background of sickle cell disease. It can likely progress to loss of vision in late stages due to vitreous hemorrhage or retinal detachment. Sickle cell disease is a structural red blood cell disorder leading to consequences in multiple systems. It is characterized by chronic red blood cell destruction, vascular injury, and tissue ischemia causing damage to the brain, eyes, heart, lungs, kidneys, spleen, and musculoskeletal system.
Polypoidal choroidal vasculopathy (PCV) is an eye disease primarily affecting the choroid. It may cause sudden blurring of vision or a scotoma in the central field of vision. Since Indocyanine green angiography gives better imaging of choroidal structures, it is more preferred in diagnosing PCV. Treatment options of PCV include careful observation, photodynamic therapy, thermal laser, intravitreal injection of anti-VEGF therapy, or combination therapy.
References
- ↑ Martin–Doyle, J. L. C. (22 October 2013). A Synopsis of Ophthalmology: Volume 4. Butterworth-Heinemann. ISBN 978-1-4832-8490-3.
- 1 2 3 4 Mishra, Chitaranjan; Tripathy, Koushik (2022), "Lipemia Retinalis", StatPearls, Treasure Island (FL): StatPearls Publishing, PMID 32310437 , retrieved 2022-04-21
- 1 2 3 D, Chaudhury; R, Meenakshi; R, Ramakrishnan; A, Mitra; S, Raju (2015-10-02). "Lipaemia Retinalis". The Official Scientific Journal of Delhi Ophthalmological Society. 26 (2): 107–110. doi: 10.7869/djo.149 .
- 1 2 3 Kempegowda, Punith; Chen, Wentin; Melson, Eka; Leong, Annabelle; Amrelia, Prashant; Syed, Ateeq (1 October 2021). "Incidental finding of lipaemia retinalis on diabetic retinal screening". Endocrinology, Diabetes & Metabolism Case Reports. 2021 (1). doi:10.1530/EDM-21-0051. ISSN 2052-0573. PMC 8558906 . PMID 34673543.
- 1 2 Wang, Patrick; Chin, Eric K.; Almeida, David R. P. (17 October 2020). "Lipemia Retinalis in a Patient with Familial Hypertriglyceridemia". Journal of Clinical Imaging Science. 10: 64. doi:10.25259/JCIS_154_2020. ISSN 2156-7514. PMC 7655997 . PMID 33194306.
- ↑ Shinkre, Noopur Deokinandan Nayak; Usgaonkar, Ugam P. S. (June 2019). "Lipemia retinalis in a 27 day old neonate: A case report". Indian Journal of Ophthalmology. 67 (6): 954–957. doi:10.4103/ijo.IJO_1310_18. ISSN 0301-4738. PMC 6552622 . PMID 31124530.
- 1 2 Kanski, Jack J.; Bowling, Brad (28 April 2011). Clinical Ophthalmology: A Systematic Approach. Elsevier Health Sciences. ISBN 978-0-7020-4511-0.
- ↑ "Lipemia Retinalis - EyeWiki". eyewiki.aao.org. Retrieved 2022-04-22.
- ↑ Ghosh, Sujoy; Collier, Andrew; Varikkara, Mohan; Palmer, Stephen J. (24 October 2011). Fundoscopy Made Easy E-Book. Elsevier Health Sciences. ISBN 978-0-7020-4991-0.
- ↑ Lu, Chao-Kung; Chen, Shih-Jen; Niu, Dau-Ming; Tsai, Chia-Chen; Lee, Fenq-Lih; Hsu, Wen-Ming (1 June 2005). "Electrophysiological Changes in Lipaemia Retinalis". American Journal of Ophthalmology. 139 (6): 1142–1145. doi:10.1016/j.ajo.2004.12.021. ISSN 0002-9394. PMID 15953465.
- ↑ Sparkes, Andrew; Caney, Sarah M. A. (20 December 2004). Feline Medicine: Self-Assessment Color Review. CRC Press. ISBN 978-1-84076-579-3.