| Train Name | Railroad | Train Endpoints in a typical [year] | Operated |
|---|
| Cabana | New Haven | New York, New York - Boston, Massachusetts [1951] | 1932–1940; 1950–1954; 1962 |
| California and Mexico Express | Santa Fe | Kansas City, Missouri - Los Angeles, California [1904] | 1886-1907 |
| California Express | Texas and Pacific | Texarkana, Texas - El Paso, Texas (with through sleepers to Los Angeles, St. Louis and other points) [1913] | 1893-1899; 1911-1918 |
| California Express | Southern Pacific | San Francisco, California - Portland, Oregon [1922] | 1921-1924 |
| California Express | Santa Fe | Chicago, Illinois - Los Angeles, California - San Francisco, California [1905] | 1886-1915 |
| California Express | Union Pacific | Salt Lake City, Utah - Los Angeles, California [1926] | 1923-1930 |
| California Fast Mail | Santa Fe | Chicago, Illinois - Los Angeles, California - San Francisco, California [1905] | 1904-1916 |
| California Limited | Santa Fe | Chicago, Illinois - Los Angeles, California [1927] | 1892-1954 |
| California Mail | Chicago and North Western Railway, Union Pacific Railroad, Southern Pacific | Chicago, Illinois - San Francisco, California [1917] | 1913-1928 |
| California Mail | Chicago, Milwaukee, St. Paul and Pacific Railroad, Southern Pacific | Chicago, Illinois - Los Angeles, California [1915] | 1914-1918 |
| California Special | Santa Fe | Temple, Texas - Clovis, New Mexico (with through trains to Los Angeles and New Orleans) [1937] | 1915-1918; 1928-1967 |
| California Zephyr | Amtrak | Chicago, Illinois - San Francisco, California [2013] | 1983–present |
| California Zephyr | Chicago, Burlington & Quincy
Denver and Rio Grande Western Railroad
Western Pacific | Chicago, Illinois - Oakland, California [1952] | 1949-1970 |
| Californian | Rock Island
Southern Pacific | Chicago, Illinois - Los Angeles, California [1937] | 1910-1930; 1937-1946 |
| Calumet | Amtrak | Chicago, Illinois - Valparaiso, Indiana [1981] | 1980-1989 |
| Camellia | Pennsylvania
Richmond, Fredericksburg & Potomac
Seaboard Air Line | New York, New York - Venice, Florida - Miami, Florida [1952] | 1947-1952 (possibly earlier and later) |
| Campus | Illinois Central Railroad | Chicago, Illinois - Carbondale, Illinois [1967] | 1967-1968 |
| Campus | Amtrak | Chicago, Illinois - Champaign, Illinois [1971] | 1971-1972 |
| Canadian | Great Northern | Seattle, Washington - Vancouver, British Columbia [1930] | 1919-1946 |
| Canadian | Canadian Pacific, Via Rail (from 1977) | Toronto, Ontario - Vancouver, British Columbia [1955] | 1955-1997; 2017 |
| Canadian | Michigan Central, later, New York Central, Canadian Pacific Railway | Chicago, Illinois - Montreal, Quebec [1921], from 1934: to Toronto, Ontario | 1914-1942, 1961 |
| Canadian-Niagara | New York Central, Canadian Pacific Railway | Chicago, Illinois - Toronto, Ontario [1952] | 1946-1961 |
| Cannon Ball | Texas and Pacific Railway, Wabash Railroad, | Chicago, Illinois - El Paso, Texas [1915] | 1898-1918 |
| Cannon Ball | Boston & Maine | Boston, Massachusetts - Plymouth, New Hampshire [1941] | 1938-1952 |
| Cannon Ball | Long Island | New York, New York - Montauk, New York [1952] | 1928-1941; 1947-1971 (possibly earlier and later) |
| Cannon Ball [2] | Pennsylvania Railroad,
Richmond, Fredericksburg and Potomac Railroad,
Atlantic Coast Line Railroad,
Norfolk and Western Railway | New York, New York - Norfolk, Virginia [1948] | 1947-1964 |
| Cape Ann | Boston & Maine | Boston, Massachusetts - Rockport, Maine [1952] | 1948-1958 |
| Cape Codder (later named, Day Cape Codder ) | New York, New Haven, & Hartford | New York, New York - Woods Hole, Massachusetts [1928] | 1925-1936 |
| Cape Codder | Amtrak | New York, New York - Hyannis, Massachusetts [1990] | 1987-1996 |
| CapeFLYER | Cape Cod Regional Transit Authority using Massachusetts Bay Transportation Authority equipment | Boston, Massachusetts - Hyannis, Massachusetts | 2013–present |
| Capital City | Amtrak | Philadelphia, Pennsylvania - Washington, DC [1993] | 1993-1994 |
| Capital City Express | Alton Railroad | Chicago, Illinois - Springfield, Illinois [1921] | 1921-1924 |
| Capital City Express | Cleveland, Cincinnati, Chicago and St. Louis Railway | Detroit, Michigan - Cleveland, Ohio [1925] | 1925-1928 |
| Capital City Express | Amtrak | New York, New York - Albany, New York [1988] | 1985-1990 |
| Capital City Special | New York Central | Cleveland, Ohio - Columbus, Ohio (with through trains to Norfolk, VA) [1930] | 1929-1958 |
| Capital Express | Pennsylvania | Pittsburgh, Pennsylvania - St. Louis, Missouri [1906] | 1904-1927 |
| Capitol | Amtrak | New York, New York - Washington, DC [1982] | 1981-1982; 1988 |
| Capitol (group of trains) | Amtrak | Oakland, California - Roseville, California [1992] | 1992-2000 |
| Capitol 400 | Chicago and North Western Railway | Chicago, Illinois - Madison, Wisconsin [1948] | 1942-1950 |
| Capitol City Special | Cleveland, Cincinnati, Chicago and St. Louis Railway | Cincinnati, Ohio - Columbus, Ohio [1920] | 1916-1924 |
| Capitol Corridor (group of trains) | Amtrak | Auburn, California - San Jose, California | 1992–present |
| Capitol Express | Pennsylvania | Pittsburgh, Pennsylvania - Indianapolis, Indiana [1928] | 1925-1929 |
| Capitol Hill Express | Pennsylvania | New York, New York - Washington, DC [1994] (called the 'Capitol Express' from 1995) | 1992-1998 |
| Capitol Limited | Baltimore & Ohio
Central of New Jersey
Reading | Jersey City, New Jersey - Chicago, Illinois via Washington, DC [1930] | 1923-1971 |
| Capitol Limited | Illinois Terminal Railroad | St. Louis, Missouri - Peoria, Illinois [1926] | 1925-1948 |
| Capitol Limited | Amtrak | Chicago, Illinois - Washington, DC | 1981–present |
| Capitol Sunrise | Amtrak | New York, New York - Washington, DC [1997] | 1997-1998 |
| Capitol-Detroit | Baltimore & Ohio | Baltimore, Maryland - Detroit, Michigan [1965] | 1964-1968 |
| Cardinal | Chicago and Eastern Illinois Railroad | Chicago, Illinois - St. Louis, Missouri [1947] | 1947-1949 |
| Cardinal | Amtrak | New York, New York - Chicago, Illinois [1981] | 1977–1981; 1982–present |
| Carl Sandburg | Amtrak | Chicago, Illinois - Quincy, Illinois [2008] | 2008–present |
| Carolina Golfer | Pennsylvania
Richmond, Fredericksburg & Potomac
Seaboard Air Line | New York, New York - Pinehurst, North Carolina [1929] | 1929-1930 |
| Carolina Special | Southern, New York Central Railroad | Chicago, Illinois - Charleston, South Carolina [1948] | 1911-1968 |
| Carolina-Florida Special | Pennsylvania
Richmond, Fredericksburg & Potomac
Seaboard Air Line | New York, New York - Tampa, Florida - Miami, Florida [1926] | 1923-1929 |
| Carolinian | Amtrak | New York, New York - Charlotte, North Carolina [1992] | 1991–present |
| Carpenter Express | Pennsylvania and its successor lines | Philadelphia, Pennsylvania - Chestnut Hill, Philadelphia, Pennsylvania [1965] | 1962-1978 |
| Cascade | Southern Pacific | Oakland, California - Portland, Oregon [1952] | 1928-1971 |
| Cascades (group of trains) | Amtrak | Eugene, Oregon - Vancouver, British Columbia|1999–present |
| Cascadia | Amtrak | Seattle, Washington - Eugene, Oregon [1996] | 1996-1997 |
| Cascadian | Great Northern | Seattle, Washington - Portland, Oregon [1930] | 1929-1958 |
| Catskill | Amtrak | New York, New York - Albany, New York [1993] | 1992-1995 |
| Cavalier [3] | Norfolk & Western | Norfolk, Virginia - Cincinnati, Ohio [1948]
(reduced to Petersburg, Virginia - Portsmouth, Ohio by October 1957) | 1928-1966 |
| Cavalier | Pennsylvania | New York, New York - Cape Charles, Virginia [1941] | 1927-1956 |
| Cavern | Santa Fe | Clovis, New Mexico - Carlsbad, New Mexico [1948] | 1940-1954 |
| Cayuga | New York Central | New York, New York - Buffalo, New York [1952] | 1929-1953; 1965-1967 |
| Cayuga | Amtrak | Albany, New York - Schenectady, New York [1984] | 1984 |
| Centennial State | Santa Fe | Denver, Colorado - Kansas City, Missouri [1948] | 1940-1950 |
| Central Express | New York Central | Buffalo, New York - Detroit, Michigan [1930] | 1927-1933 |
| Central New York Express | New York Central | New York, New York - Oswego, New York - Watertown, New York [1922] | 1919-1927 |
| Central Park | Amtrak | New York, New York - Washington, DC [1994] | 1993-1995 |
| Central States Limited | Wabash | Detroit, Michigan - Kansas City, Missouri [1930] | 1929-1933 |
| Central Texas Express | Santa Fe | Lubbock, Texas - Sweetwater, Texas [1948] | 1947-1950 |
| Century of Progress | Chicago and Eastern Illinois | Chicago, Illinois - St. Louis, Missouri [1935] | 1936-1936 |
| Challenger | Union Pacific | Chicago, Illinois - Los Angeles, California [1954] | 1935-1971 |
| Champion | Pennsylvania, then Penn Central (1968-1971)
Richmond, Fredericksburg & Potomac,
Atlantic Coast Line,
Florida East Coast until 1963,
Seaboard Coast Line Railroad, replacing ACL, 1967-1971
Amtrak from 1971 | New York, New York - Miami, Florida [1942]
New York, New York - St. Petersburg, Florida | 1939-1979 |
| Charter Oak | Amtrak | Boston, Massachusetts - Washington, DC [1971] | 1971-1972; 1984; 1988–1990; 1995-1997 |
| Cherokee | Rock Island
Southern Pacific | Memphis, Tennessee - Tucumcari, New Mexico - Los Angeles, California [1951] | 1950-1958 |
| Chesapeake | Amtrak | Washington, DC - Philadelphia, Pennsylvania [1993] | 1973-1983; 1991-1995 |
| Chesapeake and Ohio Express | Pennsylvania | New York, New York - Cincinnati, Ohio - Louisville, Kentucky [1895] | 1895-1917; 1923-1935 |
| Chesapeake and Ohio Limited | Pennsylvania, Chesapeake and Ohio Railway | New York, New York - Memphis, Tennessee [1906] | 1906-1917 |
| Chesapeake and Ohio Special | Cleveland, Cincinnati, Chicago and St. Louis Railway | Chicago, Illinois - Cincinnati, Ohio - St. Louis, Missouri [1906] | 1906-1912 |
| Cheshire | Boston & Maine | Boston, Massachusetts - White River Junction, Vermont [1952] | 1946-1958 |
| Chicago and Boston Special | New York Central and its affiliates | Chicago, Illinois - Boston, Massachusetts [1910] | 1892-1894; 1910-1920 |
| Chicago and Buffalo Special | New York Central | Chicago, Illinois - Buffalo, New York [1922] | 1918-1931 |
| Chicago and Evansville Express | Chicago and Eastern Illinois Railroad | Chicago, Illinois - Evansville, Indiana [1904] | 1902-1906 |
| Chicago and Florida Limited | Chicago and Eastern Illinois Railroad, Nashville, Chattanooga and St. Louis Railway, Atlantic Coast Line Railroad, Louisville and Nashville Railroad, Florida East Coast Railway | Chicago, Illinois - Jacksonville, Florida - Tampa, Florida - New Orleans, Louisiana - St. Louis, Missouri [1901] | 1901-1906 |
| Chicago and Florida Special | Queen and Crescent Route, Cleveland, Cincinnati, Chicago and St. Louis Railway | Chicago, Illinois - St. Augustine, Florida [1901] | 1901-1906 |
| Chicago and Minneapolis and St. Paul Limited | Illinois Central Railroad, Minneapolis and St. Louis Railway | Chicago, Illinois - Minneapolis, Minnesota [1905] | 1903-1917 |
| Chicago and New York Express | Delaware, Lackawanna and Western Railroad, Wabash Railroad | New York, New York - Chicago, Illinois [1930] | 1900-1901; 1919-1932 |
| Chicago and New York Special | New York Central and its affiliates | New York, New York - Chicago, Illinois [1925] | 1910-1928 |
| Chicago and San Francisco Express | Denver and Rio Grande Railroad | Denver, Colorado - Ogden, Utah (with through trains to Chicago and Los Angeles) [1914] | 1911-1917 |
| Chicago and Southwestern Special | Boston and Albany Railroad, New York Central, Cleveland, Cincinnati, Chicago and St. Louis Railway | Boston, Massachusetts - Chicago, Illinois - St. Louis, Missouri [1912] | 1912-1920 |
| Chicago and St. Louis Express | Pennsylvania | New York, New York - Chicago, Illinois - St. Louis, Missouri [1908] | 1893-1912 |
| Chicago and Toledo Special | Lake Shore and Michigan Southern Railway | Chicago, Illinois - Toledo, Ohio [1913] | 1909-1917 |
| Chicago Arrow | Pennsylvania
Wabash | Chicago, Illinois - Detroit, Michigan [1945] | 1942-1948 |
| Chicago Arrowhead | Chicago and North Western Railway | Chicago, Illinois - Minneapolis, Minnesota [1928] | 1927-1930 |
| Chicago Day Express | Chicago Great Western Railway | Chicago, Illinois - Minneapolis, Minnesota [1913] | 1896-1914 |
| Chicago Day Express | Illinois Central Railroad | Chicago, Illinois - Omaha, Nebraska [1908] | 1902-1909 |
| Chicago Daylight Express | Pennsylvania | Chicago, Illinois - Louisville, Kentucky - Cincinnati, Ohio [1952] | 1906-1952 |
| Chicago Express | Canadian Pacific
New York Central | Chicago, Illinois - Montreal, Quebec [1938] | 1903-1910; 1931-1960 |
| Chicago Express | Chicago and Eastern Illinois Railroad | Chicago, Illinois - Evansville, Indiana [1912] | 1902-1913 |
| Chicago Express | Chicago and North Western Railway | Chicago, Illinois - Omaha, Nebraska [1952] | ? |
| Chicago Express | Santa Fe | Chicago, Illinois - Galveston, Texas [1922] | 1886-1996; 1901-1960 |
| Chicago Express | Chicago and North Western Railway | Chicago, Illinois - Duluth, Minnesota [1922] | 1909-1915; 1919-1926 |
| Chicago Express | Pennsylvania Railroad | Chicago, Illinois - Louisville, Kentucky - Cincinnati, Ohio [1914] | 1906-1914 |
| Chicago Express | Pennsylvania Railroad | Chicago, Illinois - Philadelphia, Pennsylvania [1940] | 1929-1942 |
| Chicago Express | Erie Railroad | Chicago, Illinois - New York, New York [1930] | 1885-1888; 1891; 1914–1915; 1922-1933 |
| Chicago Express | Lehigh Valley Railroad, Grand Trunk Western Railroad | New York, New York - Chicago, Illinois - Toronto, Ontario [1923] | 1884-1896; 1903–1905; 1911–1917; 1922-1924 |
| Chicago Express | Baltimore and Ohio Railroad | Chicago, Illinois - Jersey City, New Jersey [1915] | 1913-1917 |
| Chicago Express | Chicago, Rock Island and Pacific Railroad | Chicago, Illinois - Minneapolis, Minnesota [1913] | 1903-1918 |
| Chicago Express | Chicago Great Western Railway | Chicago, Illinois - Des Moines, Iowa [1930] | 1903-1932 |
| Chicago Express | Union Pacific Railroad | Denver, Colorado - Omaha, Nebraska (with through trains to Chicago) [1914] | 1914-1918 |
| Chicago Express | Illinois Central Railroad | Chicago, Illinois - St. Louis, Missouri [1923] | 1912-1933 |
| Chicago Express | Michigan Central Railroad | Chicago, Illinois - Grand Rapids, Michigan - Detroit, Michigan [1914] | 1914-1920 |
| Chicago Fast Mail | Illinois Central Railroad | Chicago, Illinois - New Orleans, Louisiana [1908] | 1897-1911 |
| Chicago Fast Mail | Chicago and North Western Railway | Chicago, Illinois - Minneapolis, Minnesota [1906] | 1900-1913 |
| Chicago Fast Mail | Santa Fe | Denver, Colorado - Kansas City, Missouri [1910] | 1910-1915 |
| Chicago Flyer | Santa Fe | Denver, Colorado - Kansas City, Missouri [1920] | 1915-1924 |
| Chicago Limited | Chicago and North Western Railway | Chicago, Illinois - Duluth, Minnesota [1952] | 1941-1958 |
| Chicago Limited | Delaware, Lackawanna and Western Railroad, New York, Chicago and St. Louis Railroad | Hoboken, New Jersey - Chicago, Illinois [1930] | 1917-1941 |
| Chicago Limited | Monon Railroad | Chicago, Illinois - Indianapolis, Indiana [1928] | 1906-1909; 1924-1930 |
| Chicago Limited | Pennsylvania Railroad | New York, New York - Chicago, Illinois | 1903-1913 |
| Chicago Limited | Pere Marquette | Chicago, Illinois - Grand Rapids, Michigan [1931] | 1920-1936 |
| Chicago Limited | Chicago Great Western Railway | Chicago, Illinois - Des Moines, Iowa - Kansas City, Missouri [1914] | 1896-1918 |
| Chicago Limited | Lehigh Valley Railroad, Grand Trunk Western Railroad | Chicago, Illinois - New York, New York [1905] | 1897-1908 |
| Chicago Limited | Illinois Central Railroad | Chicago, Illinois - New Orleans, Louisiana [1928] | 1917-1930 |
| Chicago Limited | Chicago and Eastern Illinois Railroad | Chicago, Illinois - St. Louis, Missouri [1910] | 1908-1913 |
| Chicago Limited | Chicago, Burlington and Quincy Railroad | Chicago, Illinois - Denver, Colorado [1923] | 1909-1916; 1923–1924; 1928-1931 |
| Chicago Limited | Chicago, Burlington and Quincy Railroad | Chicago, Illinois - Minneapolis, Minnesota [1910] | 1910-1918 |
| Chicago Limited | Cleveland, Cincinnati, Chicago and St. Louis Railway | Chicago, Illinois - Cincinnati, Ohio (with through trains to St. Louis, Richmond, Washington, and other cities) [1926] | 1925-1929 |
| Chicago Limited | Chicago, Rock Island and Pacific Railroad | Chicago, Illinois - Des Moines, Iowa [1942] | 1942-1947 |
| Chicago Mail | Monon Railroad | Chicago, Illinois - Louisville, Kentucky | ? |
| Chicago Mail | New York Central | Cleveland, Ohio - Chicago, Illinois [1952] | 1949-1958 |
| Chicago Mail | Santa Fe | El Paso, Texas - Albuquerque, New Mexico [1911] | 1906-1916 |
| Chicago Mail and Express | Cleveland, Cincinnati, Chicago and St. Louis Railway | Chicago, Illinois - Cincinnati, Ohio [1923] | 1923-1930 |
| Chicago Mail Express | Pennsylvania | Chicago, Illinois - Pittsburgh, Pennsylvania [1914] | 1911-1914 |
| Chicago Mercury | New York Central | Chicago, Illinois - Detroit, Michigan [1951] | 1948-1958 |
| Chicago Midnight Express | Pennsylvania | Chicago, Illinois - Louisville, Kentucky - Cincinnati, Ohio [1914] | 1906-1916 |
| Chicago Night Express | Baltimore & Ohio | Chicago, Illinois - Wheeling, West Virginia [1952] | 1917-1922; 1928-1959 |
| Chicago Night Express | New York Central | St. Louis, Missouri - Cincinnati, Ohio - Chicago, Illinois [1952] | 1921-1952 |
| Chicago Night Express | Pennsylvania | Chicago, Illinois - Cincinnati, Ohio (with through trains to Norfolk) [1915] | 1915-1950 |
| Chicago Night Special | Cleveland, Cincinnati, Chicago and St. Louis Railway | Chicago, Illinois - Cincinnati, Ohio [1926] | 1917-1932 |
| Chicago Northwestern Limited | Chicago and North Western Railway | Chicago, Illinois - Duluth, Minnesota | ? |
| Chicago Special | Michigan Central and affiliated lines | New York, New York - Boston, Massachusetts - Chicago, Illinois [1940] | 1906-1943 |
| Chicago Special | Chicago and North Western Railway | Chicago, Illinois - Denver, Colorado [1908] | 1902-1910 |
| Chicago Special | Chicago Great Western Railway | Chicago, Illinois - Des Moines, Iowa [1926] | 1898-1918; 1921-1932 |
| Chicago Special | Chicago and North Western Railway, Union Pacific Railroad | Chicago, Illinois - Denver, Colorado [1908] | 1903-1910 |
| Chicago Special | Chicago, Milwaukee, St. Paul and Pacific Railroad | Chicago, Illinois - Minneapolis, Minnesota [1925] | 1923-1928 |
| Chicago Special | Chicago and Eastern Illinois Railroad | Chicago, Illinois - St. Louis, Missouri [1910] | 1908-1913 |
| Chicago Special | Illinois Central Railroad | Chicago, Illinois - St. Louis, Missouri [1925] | 1925-1930 |
| Chicago Special | New York Central | Chicago, Illinois - Cincinnati, Ohio [1952] | 1930-1957 |
| Chicago Vestibule Express | Lehigh Valley Railroad, Grand Trunk Western Railroad | New York, New York - Chicago, Illinois [1904] | 1897-1907 |
| Chicago Vestibuled Limited | Alton Railroad | Chicago, Illinois - Kansas City, Missouri [1900] | 1892-1904 |
| Chicago - Baltimore Express | Baltimore & Ohio | Jersey City, New Jersey - Chicago, Illinois [1932] | 1931-1934 |
| Chicago - Boston Special | Boston and Albany Railroad and affiliated lines | Chicago, Illinois - Boston, Massachusetts [1918] | 1913-1920 |
| Chicago - Buffalo Express | New York Central | Chicago, Illinois - Buffalo, New York [1921] | 1921-1931 |
| Chicago - Cedar Rapids Express | Rock Island | Chicago, Illinois - Cedar Rapids, Iowa [1912] | 1911-1915 |
| Chicago - Cleveland Special | New York Central | Chicago, Illinois - Cleveland, Ohio [1922] | 1918-1927 |
| Chicago – Des Moines Rocket | Rock Island | Chicago, Illinois - Des Moines, Iowa [1948] | 1941-1949 |
| Chicago - Duluth - Superior Express | Minneapolis, St. Paul and Sault Ste. Marie Railroad | Chicago, Illinois - Duluth, Minnesota [1915] | 1913-1917 |
| Chicago - Hot Springs Limited | Rock Island, Illinois Central Railroad | Chicago, Illinois - Hot Springs, Arkansas (Chicago - Hot Springs Special 1919-1924) [1930] | 1919-1941 |
| Chicago - Milwaukee - Sault Ste. Marie Express | Minneapolis, St. Paul and Sault Ste. Marie Railroad | Chicago, Illinois - Sault Ste. Marie, Michigan [1920] | 1911-1925; 1929-1935 |
| Chicago, Minneapolis and St. Paul Limited | | | |
| Chicago - Nashville Limited | Chicago and Eastern Illinois Railroad, Louisville and Nashville Railroad - Atlantic Coast Line Railroad | Chicago, Illinois - Jacksonville, Florida [1908] | 1907-1928 |
| Chicago - Nebraska Limited | Chicago, Burlington and Quincy Railroad | Chicago, Illinois - Omaha, Nebraska [1914] | 1910-1918 |
| Chicago - Nebraska Limited | Rock Island | Chicago, Illinois - Lincoln, Nebraska [1912] | 1912-1918 |
| Chicago - New York Express | Reading | New York, New York - Philadelphia, Pennsylvania [1939] | 1938-1941 |
| Chicago - Omaha Express | Illinois Central Railroad | Chicago, Illinois - Omaha, Nebraska (the Illinois Central Railroad also had a Chicago - Omaha Limited around this time) [1914] | 1900-1901; 1913-1917 |
| Chicago - Omaha Special | Chicago and North Western Railway | Chicago, Illinois - Omaha, Nebraska [1919] | 1919-1927 |
| Chicago - Peoria Rocket | Rock Island | Chicago, Illinois - Peoria, Illinois (the Chicago - Peoria Special 1919-1939) [1941] | 1919-1949 |
| Chicago - Pittsburgh - New York Express | Baltimore & Ohio | Jersey City, New Jersey – Chicago, Illinois [1933] | 1913-1914; 1933-1944 |
| Chicago - Pittsburgh - Washington Express | Baltimore & Ohio | Chicago, Illinois - Washington, DC [1946] | 1919-1932; 1945-1959 |
| Chicago - Pittsburgh - Washington - Baltimore Express | Chicago, Illinois - Minneapolis, Minnesota [1925] | Chicago, Illinois - Baltimore, Maryland [1922] | 1919-1931 |
| Chicago - Portland Special | Chicago and North Western Railway, Union Pacific Railroad | Chicago, Illinois - Portland, Oregon [1910] | 1901-1910 |
| Chicago - Sioux City Special | Chicago and North Western Railway | Chicago, Illinois - Sioux City, Iowa [1924] | 1921-1927 |
| Chicago - St. Louis Express | Chicago and Eastern Illinois Railroad | Chicago, Illinois - St. Louis, Missouri [1922] | 1921-1927 |
| Chicago - St. Louis Limited | Chicago and Eastern Illinois Railroad | Chicago, Illinois - St. Louis, Missouri [1915] | 1914-1924 |
| Chicago - St. Louis Special | Chicago and Eastern Illinois Railroad | Chicago, Illinois - St. Louis, Missouri [1915] | 1914-1922 |
| Chicago - Toronto Express | Lehigh Valley Railroad, Grand Trunk Western Railroad | New York, New York - Philadelphia, Pennsylvania - Toronto, Ontario - Chicago, Illinois [1908] | 1908-1915; 1925-1928 |
| Chicago - Twin Cities Express | Rock Island | Chicago, Illinois - Minneapolis, Minnesota [1925] | 1911-1936 |
| Chicago - Washington - New York Special | Baltimore & Ohio | Jersey City, New Jersey - Chicago, Illinois [1925] | 1920-1930 |
| Chicago - Wheeling Night Express | Baltimore & Ohio | Chicago, Illinois - Wheeling, West Virginia [1924] | 1913-1916; 1923-1927 |
| Chicago, Kansas City and Texas Express | Rock Island | Chicago, Illinois - Dallas, Texas [1914] | 1910-1930 |
| Chicago, Louisville and Cincinnati Express | Cleveland, Cincinnati, Chicago and St. Louis Railway | Chicago, Illinois - Cincinnati, Ohio [1912] | 1903-1914 |
| Chicago, Minneapolis and St. Paul Limited | Illinois Central Railroad, Minneapolis and St. Louis Railway | Chicago, Illinois - Minneapolis, Minnesota [1916] | 1903; 1912-1918 |
| Chicago, New York and Boston Special | New York Central and affiliated lines | New York, New York - Boston, Massachusetts - Chicago, Illinois [1900] | |
| Chicago, Omaha, Sioux City and Sioux Falls Limited | Illinois Central Railroad | Chicago, Illinois - Omaha, Nebraska - Sioux City, Iowa [1915] | 1912-1918 |
| Chicago, Pittsburgh and New York Limited | Baltimore & Ohio | Chicago, Illinois - New York, New York [1915] | 1912-1916 |
| Chicago, Pittsburgh, Washington and New York Express | Baltimore & Ohio | Chicago, Illinois - Jersey City, New Jersey [1911] | 1911-1916 |
| Chicago, Tri Cities-Des Moines Mail | Rock Island | Chicago, Illinois - Des Moines, Iowa [1930] | 1922-1931 |
| Chicagoan | Santa Fe | Chicago, Illinois - Kansas City, Missouri - Oklahoma City, Oklahoma [1952] | 1916–1929; 1938-1968 |
| Chicagoan | New York Central | New York, New York - Chicago, Illinois [1947] | 1932-1938; 1947-1967 |
| Chicagoan | Pennsylvania | Chicago, Illinois - Washington, DC [1925] | 1923-1928 |
| Chicagoan | Delaware, Lackawanna and Western Railroad, New York, Chicago and St. Louis Railroad | New York, New York - Chicago, Illinois [1948] | 1925-1928; 1943-1949 |
| Chickasaw | Illinois Central Railroad | St. Louis, Missouri - New Orleans, Louisiana [1925] | 1924-1968 |
| Chief | Santa Fe | Chicago, Illinois - Los Angeles, California [1960] | 1926-1968 |
| China and Japan Fast Mail | Chicago and North Western Railway, Union Pacific Railroad, Southern Pacific | Chicago, Illinois - Los Angeles, California - San Francisco, California - Portland, Oregon [1908] | 1906-1913 |
| Chippewa | Milwaukee Road | Chicago, Illinois - Ontonagon, Michigan [1948] | 1937-1960 (Chippewa Hiawatha 1949-1957) |
| Choctaw Rocket | Rock Island | Memphis, Tennessee - Amarillo, Texas [1948] | 1925-1958 (Choctaw Limited 1925-1941) |
| Cigar Valley | New Haven | New York, New York - Springfield, Massachusetts [1953] | 1952-1954 |
| Cincinnati and New Orleans Limited | Queen and Crescent Route | Cincinnati, Ohio - New Orleans, Louisiana - Shreveport, Louisiana [1900] | 1896-1906 |
| Cincinnati and New York Express | Pennsylvania | New York, New York - Cincinnati, Ohio [1906] | 1906-1913 |
| Cincinnati Commercial Express | Pennsylvania | Pittsburgh, Pennsylvania - Cincinnati, Ohio [1918] | 1916-1932 |
| Cincinnati Daylight Express | Pennsylvania | Chicago, Illinois - Cincinnati, Ohio [1910] | 1906-1952 |
| Cincinnati Express | Pennsylvania | Pittsburgh, Pennsylvania - Cincinnati, Ohio (the Pennsylvania Railroad had several short-lived trains with this name serving different destinations [1920] | 1919-1930 |
| Cincinnati Express | Cleveland, Cincinnati, Chicago and St. Louis Railway | St. Louis, Missouri - Cincinnati, Ohio - Chicago, Illinois [1921] | 1916-1922 |
| Cincinnati Express | Baltimore & Ohio | St. Louis, Missouri - Cincinnati, Ohio [1900] | 1897-1903 |
| Cincinnati Limited | Pennsylvania
Penn Central (1968-1971) | New York, New York - Cincinnati, Ohio [1965] | 1920-1971 |
| Cincinnati Limited | Cleveland, Cincinnati, Chicago and St. Louis Railway | Cincinnati, Ohio - Detroit, Michigan [1918] | 1917-1929 |
| Cincinnati Limited | Chicago, Indianapolis & Louisville | Chicago, Illinois - Cincinnati, Ohio [1906] | 1906-1909 |
| Cincinnati Mail | Cleveland, Cincinnati, Chicago and St. Louis Railway | Cincinnati, Ohio - Cleveland, Ohio [1928] | 1925-1934 |
| Cincinnati Mail and Express | Cleveland, Cincinnati, Chicago and St. Louis Railway | Chicago, Illinois - Cincinnati, Ohio [1923] | 1923-1930 |
| Cincinnati Mercury | New York Central | Cincinnati, Ohio - Cleveland, Ohio [1952] | 1941, 1951-1957 |
| Cincinnati Midnight Express | Pennsylvania | Chicago, Illinois - Cincinnati, Ohio [1922] | 1915-1918; 1922-1926 |
| Cincinnati Midnight Special | Pennsylvania | Chicago, Illinois - Cincinnati, Ohio [1908] | 1906-1914 |
| Cincinnati Midnight Special | Cleveland, Cincinnati, Chicago and St. Louis Railway | Cincinnati, Ohio - Cleveland, Ohio [1922] | 1913-1933 |
| Cincinnati Night Express | Pennsylvania | Chicago, Illinois - Cincinnati, Ohio [1918] | 1914-1924; 1928-1952 |
| Cincinnati Night Express | Cleveland, Cincinnati, Chicago and St. Louis Railway | Chicago, Illinois - Cincinnati, Ohio - Louisville, Kentucky [1935] | 1916-1918; 1933-1952 |
| Cincinnati Night Special | Cleveland, Cincinnati, Chicago and St. Louis Railway | Chicago, Illinois - Cincinnati, Ohio - Louisville, Kentucky [1917] | 1917-1935 |
| Cincinnati Special | New York Central and its affiliates | Chicago, Illinois - Cincinnati, Ohio [1948] | 1911-1916; 1928-1957, 1959-1964 |
| Cincinnati-Washington-New York Express | Baltimore & Ohio | Jersey City, New Jersey - Cincinnati, Ohio [1925] | 1919-1928 |
| Cincinnati, Louisville and Chicago Express | Cleveland, Cincinnati, Chicago and St. Louis Railway | Chicago, Illinois - Cincinnati, Ohio - Louisville, Kentucky [1907] | 1902; 1906-1910 |
| Cincinnatian | Baltimore and Ohio Railroad
| Cincinnati, Ohio - Detroit, Michigan [1948] | 1947-1971 |
| Cincinnatian | Monon Railroad | Chicago, Illinois - Cincinnati, Ohio | ? |
| City of Chicago | Nickel Plate, Delaware, Lackawanna and Western Railroad | New York, New York - Chicago, Illinois [1955] | 1954-1965 |
| City of Cleveland | Nickel Plate, Delaware, Lackawanna and Western Railroad | New York, New York - Chicago, Illinois [1955] | 1954-1965 |
| City of Decatur | Illinois Terminal Railroad | St. Louis, Missouri - Decatur, Illinois [1949] | 1949-1950 |
| City of Decatur | Norfolk and Western Railway | Chicago, Illinois - Decatur, Illinois | 1968-1971 |
| City of Denver | Chicago and North Western Railway (until 1955),
Milwaukee Road (from 1955),
Union Pacific | Chicago, Illinois - Denver, Colorado [1958] | 1936-1971 |
| City of Kansas City | Wabash | St. Louis, Missouri - Kansas City, Missouri [1949] | 1947-1968 |
| City of Kansas City | Union Pacific | Kansas City, Missouri - Los Angeles, California [1969] | 1969-1971 |
| City of Las Vegas | Union Pacific | Los Angeles, California - Las Vegas, Nevada [1958] | 1956-1961 |
| City of Los Angeles | Chicago and North Western Railway (until 1955),
Milwaukee Road (from 1955),
Union Pacific | Chicago, Illinois - Los Angeles, California [1948] | 1936-1971 |
| City of Memphis | Nashville, Chattanooga & St. Louis | Nashville, Tennessee - Memphis, Tennessee [1948] | 1947-1958 |
| City of Mexico | Missouri Pacific | St. Louis, Missouri - Mexico City, Mexico [1940] | 1937-1941 |
| City of Miami | Atlantic Coast Line
Central of Georgia
Florida East Coast
Illinois Central | Chicago, Illinois - Miami, Florida [1948] | 1940-1971 |
| City of Milwaukee 400 | Chicago and North Western Railway | Chicago, Illinois - Milwaukee, Wisconsin [1948] | 1942-1958 |
| City of New Orleans | Illinois Central
Amtrak | Chicago, Illinois - New Orleans, Louisiana [1952] | 1947-1971 (IC);
1971-present (Amtrak) |
| City of Portland | Chicago and North Western Railway
Union Pacific | Chicago, Illinois - Portland, Oregon [1940] | 1935-1971 |
| City of Salina | Union Pacific | Salina, Kansas - Kansas City, Missouri | 1934-1940 |
| City of San Francisco | Chicago and North Western Railway (until 1955),
Milwaukee Road (from 1955),
Union Pacific
Southern Pacific | Chicago, Illinois - San Francisco, California [1948] | 1936-1972 |
| “City of Seattle” (unofficial name) | Union Pacific | Portland, Oregon - Seattle, Washington | 1942-? |
| City of St. Louis | Union Pacific
Wabash | St. Louis, Missouri - Denver, Colorado - San Francisco, California - Los Angeles, California [1948] | 1946-1968 |
| Clamdigger | New Haven Railroad | New Haven, Connecticut - Providence, Rhode Island | ? |
| Clamdigger | Amtrak | Washington, DC - Providence, Rhode Island [1977] | 1977; 1991 |
| Cleveland and Buffalo Special | Lake Shore and Michigan Southern Railway | Cleveland, Ohio - Buffalo, New York [1910] | 1906-1935 |
| Cleveland and Cincinnati Express | Pennsylvania | New York, New York - Cleveland, Ohio - Cincinnati, Ohio [1900] | 1900-1910 |
| Cleveland and Cincinnati Special | Cleveland, Cincinnati, Chicago and St. Louis Railway | Cleveland, Ohio - Cincinnati, Ohio [1918] | 1917-1918; 1925-1936 |
| Cleveland and Detroit Express | Lake Shore and Michigan Southern Railway | Detroit, Michigan - Cleveland, Ohio [1903] | 1901-1913 |
| Cleveland and New York Special | New York Central and its affiliates | New York, New York - Cleveland, Ohio (with through cars to Boston and Toronto; aka Cleveland and New York Express) [1906] | 1904-1917 |
| Cleveland Express | New York Central | Cincinnati, Ohio - Cleveland, Ohio (many trains with this name with various end points between 1877 and 1949) [1945] | 1870s-1949 |
| Cleveland Limited | New York Central and its affiliates | New York, New York - Cleveland, Ohio [1962] | 1910-1967 |
| Cleveland Mail | New York Central | Cleveland, Ohio - Toronto, Ontario [1945] | 1942-1948 |
| Cleveland Mail | Cleveland, Cincinnati, Chicago and St. Louis Railway | Detroit, Michigan - Cleveland, Ohio [1919] | 1919-1927 |
| Cleveland Mercury | New York Central | Detroit, Michigan - Cleveland, Ohio [1950] | 1950-1959 |
| Cleveland Midnight Special | Cleveland, Cincinnati, Chicago and St. Louis Railway | Cincinnati, Ohio - Cleveland, Ohio (with through trains to the south) [1915] | 1913-1938 |
| Cleveland Night Express | Baltimore and Ohio Railroad | Baltimore, Maryland - Cleveland, Ohio [1948] | 1942-1962 |
| Cleveland Special | New York Central | Cincinnati, Ohio - Cleveland, Ohio [1952] | 1919-1924; 1932-1957 |
| Cleveland – Chicago Express | New York Central | Chicago, Illinois - Cleveland, Ohio [1948] | 1948-1949 |
| Cleveland - Chicago Special | New York Central | Chicago, Illinois - Cleveland, Ohio [1921] | 1918-1927 |
| Cleveland - Cincinnati Express | Cleveland, Cincinnati, Chicago and St. Louis Railway | Cleveland, Ohio - Cincinnati, Ohio [1923] | 1923-1928 |
| Cleveland – Cincinnati Night Special | New York Central | St. Louis, Missouri - Cincinnati, Ohio [1942] | 1939-1948 |
| Cleveland – Cincinnati Special | New York Central | Cleveland, Ohio - Cincinnati, Ohio [1948] | 1929-1930; 1937-1960 |
| Cleveland - Detroit Express | New York Central | Detroit, Michigan - Cleveland, Ohio [1930] | 1926-1937 |
| Cleveland - Detroit Special | New York Central | Detroit, Michigan - Cleveland, Ohio [1930] | 1926-1931 |
| Cleveland - Indianapolis Special | Cleveland, Cincinnati, Chicago and St. Louis Railway | Detroit, Michigan - Cleveland, Ohio - Indianapolis, Indiana [1926] | 1925-1930 |
| Cleveland - New York Express | Erie Railroad | New York, New York - Cleveland, Ohio - Pittsburgh, Pennsylvania [1922] | 1922-1927 |
| Cleveland – St. Louis Special | New York Central | Cleveland, Ohio - St. Louis, Missouri [1952] | 1931-1956 |
| Cleveland - Washington Night Express | Baltimore and Ohio Railroad | Cleveland, Ohio - Washington, DC [1945] | 1942-1946 |
| Cleveland, Cincinnati and Chicago Express | Pennsylvania | New York, New York - Chicago, Illinois (with many different end points over the years) [1920] | 1911-1930 |
| Cleveland, Cincinnati and St. Louis Express | New York Central | New York, New York - Cleveland, Ohio - St. Louis, Missouri [1901] | 1901-1906 |
| Cleveland, Oil City and Buffalo Express | Erie Railroad | New York, New York - Cleveland, Ohio [1911] | 1911-1915 |
| Clevelander | Pennsylvania | New York, New York - Cleveland, Ohio [1948] | 1916-1964 |
| Clipper | Detroit and Mackinac Railway | Detroit, Michigan - Alpena, Michigan [1938] | 1936-1942 |
| Clocker (group of trains) | Amtrak | New York, New York - Philadelphia, Pennsylvania [1993] | 1991-2004 |
| Cloverland | Chicago and North Western Railway | Chicago, Illinois - Ishpeming, Michigan [1939] | 1931-1941 |
| Coast Daylight | Southern Pacific
Amtrak | San Francisco, California - Los Angeles, California | 1937-1974 |
| Coast Line Florida Mail | Atlantic Coast Line
Richmond, Fredericksburg & Potomac | New York, New York - Tampa, Florida [1941] | 1921-1942 |
| Coast Starlight | Amtrak | Los Angeles, California - Seattle, Washington [2013] | 1971-present |
| Coast-to-Coast Limited | Seaboard Air Line Railroad | St. Petersburg, Florida - West Palm Beach, Florida [1925] | 1925-1927 |
| Coastal Classic | Alaska Railroad | Anchorage, Alaska - Seward, Alaska | ?-present |
| Coaster | Southern Pacific | Los Angeles, California - San Francisco, California [1948] | 1905; 1908–1916; 1928-1949 |
| Colonial | Pennsylvania Railroad
New York, New Haven and Hartford Railroad
Penn Central
Amtrak | Washington, DC - New York, New York - Boston, Massachusetts [1952] | 1892-1971 (PRR-NH)
1971-1973; 1976–2992; 1998 (Amtrak) |
| Colorado and California Express | Rock Island, Denver and Rio Grande Western Railroad, Southern Pacific | Chicago, Illinois - San Francisco, California [1915] | 1906-1918 |
| Colorado and New Mexico Express | Denver and Rio Grande Western Railroad | Denver, Colorado - Alamosa, Colorado (many other endpoints) [1929] | 1896; 1901–1913; 1929-1936 |
| Colorado and St. Louis Express | Rock Island | St. Louis, Missouri - Denver, Colorado [1919] | 1919-1927; 1931-1934 |
| Colorado Eagle | Denver and Rio Grande Western,
Missouri Pacific | St. Louis, Missouri - Denver, Colorado [1942] | 1942-1964 |
| Colorado Express | Rock Island | Kansas City, Missouri - Denver, Colorado [1948] | 1919-1950 |
| Colorado Express | Chicago, Milwaukee, St. Paul and Pacific Railroad, Union Pacific Railroad | Chicago, Illinois - Denver, Colorado [1904] | 1904-1905; 1915-1921 |
| Colorado Express | Denver and Rio Grande Railroad | Denver, Colorado - Salida, Colorado [1902] | 1901-1914 |
| Colorado Express | Chicago & North Western
Union Pacific | Chicago, Illinois - Denver, Colorado [1912] | 1908-1930 |
| Colorado Express | Santa Fe | Chicago, Illinois - Denver, Colorado [1912] | 1905-1931 |
| Colorado Fast Mail | Santa Fe | Chicago, Illinois - Denver, Colorado [1912] | 1910-1925 |
| Colorado Flyer | Rock Island | St. Louis, Missouri - Colorado Springs, Colorado [1911] | 1903; 1911-1930 |
| Colorado Flyer | Santa Fe | Chicago, Illinois - Denver, Colorado [1912] | 1902-1934 |
| Colorado Limited | Chicago, Burlington and Quincy | Chicago, Illinois - Denver, Colorado [1923] | 1911-1918; 1923-1938 |
| Colorado Special | Chicago and North Western Railway | Chicago, Illinois - Denver, Colorado [1916] | 1898-1910; 1916-1927 |
| Colorado Special | Chicago, Milwaukee, St. Paul and Pacific Railroad, Union Pacific Railroad | Chicago, Illinois - Denver, Colorado [1916] | 1899; 1906-1919 |
| Colorado Springs and Denver Express | Denver and Rio Grande Railroad, Missouri Pacific Railroad | St. Louis, Missouri - Denver, Colorado [1921] | 1918-1930 |
| Colorado Springs and Eastern Express | Denver and Rio Grande Railroad, Missouri Pacific Railroad | St. Louis, Missouri - Denver, Colorado [1928] | 1925-1930 |
| Colorado Springs, Pueblo, Eastern Express | Denver and Rio Grande Railroad, Missouri Pacific Railroad | St. Louis, Missouri - Denver, Colorado [1915] | 1915-1924 |
| Colorado, Utah and New Mexico Express | Denver and Rio Grande Railroad | Denver, Colorado - Salt Lake City, Utah [1915] | 1915-1928 |
| Coloradoan | Chicago, Burlington and Quincy | Chicago, Illinois - Denver, Colorado [1952] | 1950-1963 |
| Columbia River Express | Spokane, Portland & Seattle | Portland, Oregon - Pasco, Washington [1952] | 1929-1959 |
| Columbian | Baltimore and Ohio | Jersey City, New Jersey - Washington, DC [1935] | 1931-1941 |
| Jersey City, New Jersey - Chicago, Illinois [1952] | 1941-1958 |
| Baltimore, Maryland - Chicago, Illinois [1958] | 1958-1964 |
| Columbian | Milwaukee Road | Chicago, Illinois - Tacoma, Washington [1948] | 1911–1930; 1947-1955 |
| Columbine | Chicago & North Western
Union Pacific | Chicago, Illinois - Denver, Colorado [1933] | 1927-1950 |
| Columbus and Cincinnati Express | Cleveland, Cincinnati, Chicago and St. Louis Railway and affiliated lines | New York, New York - Boston, Massachusetts - Cincinnati, Ohio [1902] | 1902-1919 |
| Columbus - Cincinnati Special | Cleveland, Cincinnati, Chicago and St. Louis Railway | Cleveland, Ohio - Cincinnati, Ohio [1922] | 1917-1948 |
| Columbus - Cleveland Express | Cleveland, Cincinnati, Chicago and St. Louis Railway | Cleveland, Ohio - Cincinnati, Ohio [1922] | 1917-1928 |
| Comet | New Haven | Boston, Massachusetts - Providence, Rhode Island | 1935-c. 1942 |
| Commander | New Haven | New York, New York - Boston, Massachusetts [1942] | 1942-1950; 1954-1956 |
| Commercial Express | Pennsylvania Railroad | New York, New York - St. Louis, Missouri [1915] | 1913-1933; 1936-1942 |
| Commercial Limited | Chicago, Burlington and Quincy | Chicago, Illinois - Minneapolis, Minnesota [1912] | 1911-1914; 1927-1930 |
| Commercial Traveler | Clover Leaf (New York, Chicago and St. Louis Railroad from 1923) | St. Louis, Missouri - Toledo, Ohio [1913] | 1902-1931 |
| Commodore | Pennsylvania Railroad | Philadelphia, Pennsylvania - Long Branch, New Jersey [1935] | 1933-1938 |
| Commodore Vanderbilt | New York Central | Chicago, Illinois - New York, New York [1956] | 1929-1960 |
| Commuter 400 | Chicago and North Western Railway | Chicago, Illinois - Milwaukee, Wisconsin (called the 'Commuter' before 1942) [1948] | 1936-1968 |
| Concord | Amtrak | Boston, Massachusetts - Washington, DC [1997] | 1997-1998 |
| Congressional | Pennsylvania Railroad | Washington, DC - New York, New York [1948] | 1882-1949 |
| Congressional | Amtrak | Washington, DC - New York, New York [1990] | 1978-1994; 1997-1998 |
| Connecticut Yankee | Boston and Maine, New York, New Haven and Hartford (until 1968), Penn Central (1969-1971), Amtrak (from 1971) | Boston & New York, New York - Quebec City, Quebec [1946] - Washington, DC - Springfield, Massachusetts [1983] | 1936-1977; 1983-1995 |
| Constitution | Pennsylvania Railroad | Washington, DC - New York, New York [1948] | 1933-1956 |
| Continental Limited | Wabash (and connecting lines) | St. Louis, Missouri - Chicago, Illinois - New York, New York - Boston, Massachusetts [1916] | 1898-1917 |
| Continental Limited | Chicago & North Western, Union Pacific Railroad, Southern Pacific | Chicago, Illinois - San Francisco, California [1921] | 1921-1931 |
| Copper Country Limited | Milwaukee Road,
Duluth, South Shore & Atlantic (until December 1960)
Soo Line (after December 1960) | Chicago, Illinois - Champion, Michigan - Calumet, Michigan [1925] | 1908-1968 |
| Corn Belt Special | Peoria and Eastern Railway (operated by New York Central) | Indianapolis, Indiana - Pekin, Illinois | 1955-1957 |
| Corn Belt Rocket | Rock Island | Chicago, Illinois - Omaha, Nebraska [1952] | 1948-1967 |
| Corn King | Chicago & North Western | Chicago, Illinois - Omaha, Nebraska [1933] | 1929-1941 |
| Cotton Belter | St. Louis Southwestern | St. Louis, Missouri - Dallas, Texas [1939] | 1939-1941 |
| Cotton Blossom | Richmond, Fredericksburg and Potomac Railroad, Seaboard Air Line Railroad | Washington, DC - Birmingham, Alabama [1952] | 1947-1955 |
| Cotton States Special | Seaboard Air Line, Pennsylvania Railroad, Richmond, Fredericksburg and Potomac Railroad | New York, New York and Portsmouth, Virginia - Birmingham, Alabama [1942] | 1934-1947 |
| Coyote | Colorado Midland Railway | Denver, Colorado - Grand Junction, Colorado [1900] | 1900-1908 |
| Cracker | Southern Railway | Atlanta, Georgia - Brunswick, Georgia [1945] | 1940-1952 |
| Cranberry | New Haven | Boston, Massachusetts - Woods Hole, Massachusetts | c. 1949 - c. 1958 |
| Cream City Special | Chicago North Shore and Milwaukee Railroad | Chicago, Illinois - Milwaukee, Wisconsin [1930] | 1929-1933 |
| Creole | Illinois Central | Chicago, Illinois and Louisville, Kentucky - New Orleans, Louisiana [1938] | 1931-1946; 1954-1967 |
| Crescent | Southern Railway
Amtrak | New York, New York - New Orleans, Louisiana (also called 'Southern Crescent' and 'Crescent Limited' for many years) [2014] | 1891-1979 (Southern);
1979-present (Amtrak) |
| Crescent City Special | Southern Railway | Cincinnati, Ohio - New Orleans, Louisiana [1920] | 1917-1924 |
| Crescent City Special | Cleveland, Cincinnati, Chicago and St. Louis Railway | Danville, Illinois - Evansville, Indiana [1935] | 1931-1938 |
| Cross-Florida Limited | Seaboard Air Line | St. Petersburg, Florida - West Palm Beach, Florida [1926] | c.1925-c.1930 |
| Cross-Florida Night Limited | Seaboard Air Line | St. Petersburg, Florida - Miami, Florida | 1927-1930 |
| Crusader | Reading; Conrail from 1976 | Philadelphia, Pennsylvania - Jersey City, New Jersey [1940] | 1937–1968; 1973-1980 |
| Cumberland | Boston & Maine | Portland, Maine - Boston, Massachusetts [1952] | 1951-1956 |
| Curfew | Chicago and Eastern Illinois Railroad | Chicago, Illinois - St. Louis, Missouri [1925] | 1925-1930 |
