| Building | Image | Location | First built | Use | Notes |
|---|
| Molalla Log House | | near Canby, Oregon | 1790s | Residence | Unknown who constructed the structure (possibly trappers, Native American or Russians). Building was moved to a new site in 2021 in the Hopkins Demonstration Forest. [1] |
| Jason Lee House | | Salem, Oregon | 1841 | Residence | One of the oldest frame building remaining in the state |
| Methodist Mission Parsonage | | Salem, Oregon | 1841 | Residence | One of the oldest frame building remaining in the state |
| Francis Ermatinger House | | Oregon City, Oregon | 1843 | Residence | Long thought to be the oldest house in Clackamas County [2] |
| Delaney–Edwards House | | Salem, Oregon | 1845 | Residence | Currently a Bed & Breakfast |
| St. Paul Roman Catholic Church (St. Paul, Oregon) | | St. Paul, Oregon | 1846 | Church | Oldest church in Oregon and oldest brick building in Pacific Northwest |
| McLoughlin House National Historic Site | | Oregon City, Oregon | 1846 | Residence | Home of John McLoughlin a leader of the Hudson's Bay Company and the "father of Oregon" |
| John D. Boon House | | Salem, Oregon | 1847 | Residence | |
| Butteville Jail | | Champoeg, Oregon | 1848 | Jail | |
| Silas Jacob N. Beeks House | | Forest Grove, Oregon | 1848 | Residence | |
| Watson–Price Farmstead Barn | | Benton County, Oregon | 1848 | Barn | |
| William L. Holmes House | | Oregon City, Oregon | 1848 | Residence | |
| Dr. Forbes Barclay House | | Oregon City, Oregon | 1849 | Residence | |
| Thomas and Walter Monteith House | | Albany, Oregon | 1849 | Residence | |
| Dayton Common School | | Dayton, Oregon | 1850 | School | |
| Granville H. Baber House | | Linn County, Oregon | 1850 | Residence | |
| Malcolm A. Moody House | | The Dalles, Oregon | 1850 | Residence | Oldest house in The Dalles |
| Morton Matthew McCarver House | | Oregon City, Oregon | 1850 | Residence | |
| Tualatin Academy | | Forest Grove, Oregon | 1850 | University Building | Oldest university building in the state |
| White–Kellogg House | | Oregon City, Oregon | 1850 | Residence | |
| Capt. John C. Ainsworth House | | Oregon City, Oregon | 1851 | Residence | |
| Hamilton Campbell House | | Marion County, Oregon | 1851 | Residence | |
| Knighton House | | St. Helens, Oregon | 1851 | Residence | Oldest house in Columbia County [3] |
| Levi Hagey House | | Dundee, Oregon | 1851 | Residence | |
| Matthew Murphy House | | St. Paul, Oregon | 1851 | Residence | |
| Hiram Brown House | | Astoria, Oregon | 1852 | Residence | A part of the Shively–McClure Historic District |
| Mountain House | | Ashland, Oregon | 1852 | Residence | |
| Robert Newell House | | Champoeg, Oregon | 1852 | Residence | |
| Watson–Price Farmstead | | Benton County, Oregon | 1852 | Residence | |
| Amos Cook House | | Dayton, Oregon | 1853 | Residence | |
| John Phillips House | | Polk County, Oregon | 1853 | Residence | |
| Lane County Clerk's Building | | Eugene, Oregon | 1853 | Residence | |
| Washington County Jail | | Washington County, Oregon | 1853 | Jail | |
| West Union Baptist Church | | Hillsboro, Oregon | 1853 | Church | |
| Andrew Jackson and Sarah Jane Masters House | | Aloha, Oregon | 1854 | Residence | |
| Creed Floed House | | Roseburg, Oregon | 1854 | Residence | |
| Jacob Conser House | | Jefferson, Oregon | 1854 | Residence | |
| Daniel and Catherine Christian House | | Eugene, Oregon | 1855 | Residence | Oldest house in Eugene |
| James Mechlin Anderson House | | Marion County, Oregon | 1855 | Residence | |
| John Fiechter House | | Corvallis, Oregon | 1855 | Residence | |
| Patrick F. McManus House | | Phoenix, Oregon | 1855 | Residence | |
| Tigard-Rogers House | | Portland, Oregon | 1855 | Residence | Oldest house in Portland |
| Alvin T. Smith House | | Forest Grove, Oregon | 1854-1856 | Residence | |
| Bybee–Howell House | | Sauvie Island, Oregon | 1856 | Residence | |
| Charles Applegate House | | Yoncalla, Oregon | 1856 | Residence | [4] |
| Fort Yamhill Blockhouse | | Dayton, Oregon | 1856 | Blockhouse | |
| Hiram A. Straight House | | Oregon City, Oregon | 1856 | Residence | |
| Horace Baker Log Cabin | | Carver, Oregon | 1856 | Residence | |
| Mt. Pleasant Presbyterian Church | | Linn County, Oregon | 1856 | Church | |
| Burford-Stanley House | | Monmouth, Oregon | 1857 | Residence | |
| Charles Gaylord House | | Corvallis, Oregon | 1857 | Residence | |
| Fort Dalles Surgeon's Quarters | | The Dalles, Oregon | 1857 | Residence | |
| Fort Hoskins Commander's House | | Benton County, Oregon | 1857 | Residence | Moved back to the fort from Pedee Creek Road; only surviving structure of the fort |
| Hallock–McMillan Building | | Portland, Oregon | 1857 | Commercial | Oldest surviving commercial building and oldest brick building in Portland |
| Hannah and Eliza Gorman House | | Corvallis, Oregon | 1857 | Residence | |
| Jesse H. Caton House | | Corvallis, Oregon | 1857 | Residence | |
| Palmer House | | Dayton, Oregon | 1857 | Residence | |
| Sam Brown House | | Gervais, Oregon | 1857 | Residence | |
| Fulton–Taylor House | | The Dalles, Oregon | 1858 | Residence | |
| Jesse and Julia Harritt House | | Salem, Oregon | 1858 | Residence | |
| John P. Walker House | | Ashland, Oregon | 1858 | Residence | |
| John Sweek House | | Tualatin, Oregon | 1858 | Residence | |
| Pleasant Grove Presbyterian Church | | Salem, Oregon | 1858 | Church | |
| Rock Creek Methodist Church | | Clackamas County, Oregon | 1858 | Church | |
| Stephen and Parthena M. Blank House | | Forest Grove, Oregon | 1858 | Residence | |
| Andrew Smith House | | Dayton, Oregon | 1859 | Residence | |
| Augustus Fanno Farmhouse | | Beaverton, Oregon | 1859 | Residence | |
| Butteville Academy | | Champoeg, Oregon | 1859 | School | |
| First Wasco County Courthouse | | The Dalles, Oregon | 1859 | Courthouse | |
| Horace L. Dibble House | | Molalla, Oregon | 1859 | Residence | |
| Hugh Fields House | | Linn County, Oregon | 1859 | Residence | |
| John B. White House | | Jackson County, Oregon | 1859 | Residence | |
| Spring Valley Presbyterian Church | | Zena, Oregon | 1859 | Church | |
| 333 NE First Street | | Oakland, Oregon | 1859 | Residence | Moved from Old Town Oakland in the 1870s to its current location; part of the Oakland Historic District |
| Waller Hall | | Salem, Oregon | 1867 | University building | Oldest university building in use on West Coast [5] |
| Cape Blanco Lighthouse | | Curry County, Oregon | 1870 | Lighthouse | Oldest remaining lighthouse in the state |