Metallocarboxypeptidase D

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Metallocarboxypeptidase D
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EC no. 3.4.17.22
CAS no. 153967-26-1
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Metallocarboxypeptidase D (EC 3.4.17.22, carboxypeptidase D (cattle, human, mouse, rat), gp180 (duck)) is an enzyme. [1] [2] [3] This enzyme catalyses the following chemical reaction

Releases C-terminal Arg and Lys from polypeptides

This enzyme is activated by Co2+, and inhibited by guanidinoethylmercaptosuccinic acid.

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References

  1. Kuroki K, Eng F, Ishikawa T, Turck C, Harada F, Ganem D (June 1995). "gp180, a host cell glycoprotein that binds duck hepatitis B virus particles, is encoded by a member of the carboxypeptidase gene family". The Journal of Biological Chemistry. 270 (25): 15022–8. doi: 10.1074/jbc.270.25.15022 . PMID   7797483.
  2. Song L, Fricker LD (October 1995). "Purification and characterization of carboxypeptidase D, a novel carboxypeptidase E-like enzyme, from bovine pituitary". The Journal of Biological Chemistry. 270 (42): 25007–13. doi: 10.1074/jbc.270.42.25007 . PMID   7559630.
  3. Song L, Fricker LD (November 1996). "Tissue distribution and characterization of soluble and membrane-bound forms of metallocarboxypeptidase D". The Journal of Biological Chemistry. 271 (46): 28884–9. doi:10.1074/jbc.271.46.28884. PMID   8910535.