Methylecgonone reductase

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Methylecgonone reductase
Identifiers
EC no. 1.1.1.334
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Methylecgonone reductase (EC 1.1.1.334, MecgoR (gene name)) is an enzyme with systematic name ecgonine methyl ester:NADP+ oxidoreductase. [1] This enzyme catalyses the following chemical reaction

ecgonine methyl ester + NADP+ ecgonone methyl ester + NADPH + H+

The enzyme from the plant Erythroxylum coca participates in the biosynthesis of cocaine.

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References

  1. Jirschitzka J, Schmidt GW, Reichelt M, Schneider B, Gershenzon J, D'Auria JC (June 2012). "Plant tropane alkaloid biosynthesis evolved independently in the Solanaceae and Erythroxylaceae". Proceedings of the National Academy of Sciences of the United States of America. 109 (26): 10304–9. Bibcode:2012PNAS..10910304J. doi: 10.1073/pnas.1200473109 . PMC   3387132 . PMID   22665766.