Methylecgonone reductase

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Methylecgonone reductase
Identifiers
EC no. 1.1.1.334
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
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PMC articles
PubMed articles
NCBI proteins

Methylecgonone reductase (EC 1.1.1.334, MecgoR (gene name)) is an enzyme with systematic name ecgonine methyl ester:NADP+ oxidoreductase. [1] This enzyme catalyses the following chemical reaction: [2]

 
 
 
H+
Methylecgonone reductase
 
H+
 
 

The enzyme from the plant Erythroxylum coca participates in the biosynthesis of cocaine.

References

  1. Jirschitzka J, Schmidt GW, Reichelt M, Schneider B, Gershenzon J, D'Auria JC (June 2012). "Plant tropane alkaloid biosynthesis evolved independently in the Solanaceae and Erythroxylaceae". Proceedings of the National Academy of Sciences of the United States of America. 109 (26): 10304–9. Bibcode:2012PNAS..10910304J. doi: 10.1073/pnas.1200473109 . PMC   3387132 . PMID   22665766.
  2. Enzyme 1.1.1.334 at KEGG Pathway Database.