Neuroanatomy of memory

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The neuroanatomy of memory encompasses a wide variety of anatomical structures in the brain.

Contents

Subcortical structures

Hippocampus

The hippocampus NIA human brain drawing.jpg
The hippocampus

The hippocampus is a structure in the brain that has been associated with various memory functions. It is part of the limbic system, and lies next to the medial temporal lobe. It is made up of two structures, the Ammon's Horn, and the Dentate gyrus, each containing different types of cells. [1]

Cognitive maps

There is evidence that the hippocampus contains cognitive maps in humans. In one study, single-cell recordings were taken from electrodes implanted in a rat's hippocampus, and it was found that certain neurons responded strongly only when the rat was in certain locations. These cells are called place cells, and collections of these cells can be considered to be mental maps. Individual place cells do not only respond to one unique area only however, the patterns of activation of these cells overlap to form layered mental maps within the hippocampus. A good analogy is the example of the same television or computer screen pixels being used to light up any trillions of possible combinations to produce images, just as the place cells can be used in any multiple possible combinations to represent mental maps. The hippocampus' right side is more oriented towards responding to spatial aspects, whereas the left side is associated with other context information. Also, there is evidence that experience in building extensive mental maps, such as driving a city taxi for a long time (since this requires considerable memorization of routes), can increase the volume of one's hippocampus. [2]

Encoding

Damage to the hippocampus and surrounding area can cause anterograde amnesia, the inability to form new memories. [3] This implies that the hippocampus is important not only for storing cognitive maps, but for encoding memories.

The hippocampus is also involved in memory consolidation, the slow process by which memories are converted from short to long term memory. This is supported by studies in which lesions are applied to rat hippocampi at different times after learning. [2] The process of consolidation may take up to a couple years.

It has also been found that it is possible to form new semantic memories without the hippocampus, but not episodic memories, which means that explicit descriptions of actual events (episodic) cannot be learned, but some meaning and knowledge is gained from experiences (semantic). [2]

Cerebellum

The cerebellum Brain bulbar region.svg
The cerebellum

The cerebellum ("little brain") is a structure located at the rear of the brain, near the spinal cord. It looks like a miniature version of the cerebral cortex, in that it has a wavy, or convoluted surface. [3]

Unlike the hippocampus which is involved in the encoding of complex memories, the cerebellum plays a role in the learning of procedural memory, and motor learning, such as skills requiring co-ordination and fine motor control. [4] An example of a skill requiring procedural memory would be playing a musical instrument, or driving a car or riding a bike. Individuals with transient global amnesia that have difficulty forming new memories and/or remembering old events may sometimes retain the ability to perform complex musical pieces, suggesting that procedural memory is completely dissociated from conscious memory, also known as explicit memory.

This separation makes sense if the cerebellum, which is far removed from the hippocampus, is responsible for procedural learning. The cerebellum is more generally involved in motor learning, and damage to it can result in problems with movement, specifically it is considered to co-ordinate timing and accuracy of movements, and to make long-term changes (learning) to improve these skills. [1]

Amygdala

The amygdala. Amgydala.jpg
The amygdala.

Located above the hippocampus in the medial temporal lobes are two amygdalae (singular "amygdala"). The amygdalae are associated with both emotional learning and memory, as it responds strongly to emotional stimuli, especially fear. These neurons assist in encoding emotional memories and enhancing them. This process results in emotional events being more deeply and accurately encoded into memory. Lesions to the amygdalae in monkeys have been shown to impair motivation, as well as the processing of emotions. [5]

Memory of fear conditioning

Pavlovian conditioning tests have shown the active role of the amygdala in fear conditioning in rats. Research involving lesions to the basolateral nucleus have shown a strong association with memories involving fear. The central nucleus is linked with the behavioral responses that are dependent on the basolateral's reaction to fear. [6] The central nucleus of the amygdala is also linked to emotions and behaviors motivated by food and sex. [7]

Memory consolidation

Emotional experiences and events are somewhat fragile and take a while to be completely set into memory. This slow process, referred to as consolidation, allows emotions to influence the way the memory is stored. [7]

The amygdala is involved in memory consolidation, which is the process of transferring information that is currently in working memory into ones long-term memory. This process is also known as memory modulation. [7] The amygdala works to encode recent emotional information into memory. Memory research has shown that the greater ones emotional arousal level at the time of the event, the greater the chance that the event will be remembered. [7] This may be due to the amygdala enhancing the emotional aspect of the information during encoding, causing the memory to be processed at a deeper level and therefore, more likely to withstand forgetting.

Basal ganglia and motor memory

Basal ganglia (red) and related structures (blue) Basal ganglia and related structures (2).svg
Basal ganglia (red) and related structures (blue)

The basal ganglia are a group of nuclei which are located in the medial temporal lobe, above the thalamus and connected to the cerebral cortex. Specifically, the basal ganglia includes the subthalamic nucleus, substantia nigra, the globus pallidus, the ventral striatum and the dorsal striatum, which consists of the putamen and the caudate nucleus. [8] The basic functions of these nuclei deal with cognition, learning, and motor control and activities. The basal ganglia are also associated with learning, memory, and unconscious memory processes, such as motor skills and implicit memory. [4] Particularly, one division within the ventral striatum, the nucleus accumbens core, is involved in the consolidation, retrieval and reconsolidation of drug memory. [9]

The caudate nucleus is thought to assist in learning and memory of associations taught during operant conditioning. Specifically, research has shown that this part of the basal ganglia plays a role in acquiring stimulus-response habits, as well as in solving sequence tasks. [8]

Damage to the basal ganglia has been linked to dysfunctional learning of motor and perceptual-motor skills. Most disorders that are associated with damage to these areas of the brain involve some type of motor dysfunction, as well as trouble with mental switching between tasks in working memory. Such symptoms are often present in those who suffer from dystonia, athymhormic syndrome, Fahr's syndrome, Huntington's disease or Parkinson's disease. Huntington's and Parkinson's disease involve both motor deficits and cognitive impairment. [8]

Cortical structures

The cortical structures Lobes of the brain NL.svg
The cortical structures

Frontal lobe

The frontal lobes are located at the front of each cerebral hemisphere and positioned anterior to the parietal lobes. It is separated from the parietal lobe by the primary motor cortex, which controls voluntary movements of specific body parts associated with the precentral gyrus. [10] The cortex here serves our ability to plan the day, organize work, type a letter, pay attention to details and control the movements of your arms and legs. It also contributed to your personality and behaviour.

When considering the frontal lobes in regards to memory, we see that it is very important in the coordination of information. Therefore, the frontal lobes are important in working memory. For example, when you are thinking about how to get to a mall you have never been to before, you combine various bits of knowledge you already have: the layout of the city the mall is in, information from a map, knowledge of traffic patterns in that area and conversations with your friends about the location of the mall. By actively using all of this information, you can determine the best route for you to take. This action involves the controlled use of information in working memory, coordinated by the frontal lobes.

The frontal lobes help a person select out memories that are most relevant on a given occasion. It can coordinate various types of information into a coherent memory trace. [11] For example, the knowledge of the information itself, as well as knowing where information came from must be put together into a single memory representation; this is called source monitoring. [12] Sometimes we experience situations where information becomes separated, such as when we recall something, but cannot remember where we remember it from; this is referred to as a source monitoring error. [12]

The frontal lobes are also involved in the ability to remember what we need to do in the future; this is called prospective memory. [13]

Temporal lobe

The temporal lobes are a region of the cerebral cortex that is located beneath the Sylvian fissure on both the left and right hemispheres of the brain. [14] Lobes in this cortex are more closely associated with memory and in particular autobiographical memory. [15]

The temporal lobes are also concerned with recognition memory. This is the capacity to identify an item as one that was recently encountered. [16] Recognition memory is widely viewed as consisting of two components, a familiarity component (i.e. Do I know this person waving at me?) and a recollective component (i.e. That is my friend Julia, from evolutionary psychology class).

Damage to the temporal lobe can affect an individual in a litany of ways ranging from: disturbance of auditory sensation and perception, disturbance of selective attention of auditory and visual input, disorders of visual perception, impaired organization and categorization of verbal material, disturbance of language comprehension, and altered personality. [17]

In regard to memory, temporal lobe damage can impair long-term memory. [17] Thus, general semantic knowledge or more personal episodic memories of one's childhood could be affected.

Parietal lobe

The parietal lobe is located directly behind the central sulcus, superior to the occipital lobe and posterior to the frontal lobe, visually at the top of the back of the head. [18] The make up of the parietal lobe is defined by four anatomical boundaries in the brain, providing a division of all the four lobes. [18]

The parietal lobe has many functions and duties in the brain and its main functioning can be divided down into two main areas: (1) sensation and perception (2) constructing a spatial coordinate system to represent the world around us. [19] The parietal lobe helps us to mediate attention when necessary and provides spatial awareness and navigational skills. Also, it integrates all of our sensory information (touch, sight, pain etc.) to form a single perception. [19] Parietal lobe gives the ability to focus our attention on different stimuli at the same time, PET scans show high activity in the parietal lobe when participates being studied were asked to focus their attention at two separate areas of attention. [19] Parietal lobe also assists with verbal short term memory and damage to the supramarginal gyrus cause short term memory loss. [20]

Damage to the parietal lobe results in the syndrome ‘neglect' which is when patients treat part of their body or objects in their visual field as though it never existed. Damage to the left side of the parietal lobe can result in what is called Gerstmann syndrome. [21] It includes right-left confusion, difficulty with writing (agraphia) and difficulty with mathematics (acalculia). It can also produce disorders of language (aphasia) and the inability to perceive objects. [21] Damage to the right parietal lobe can result in neglecting part of the body or space (contralateral neglect), which can impair many self-care skills such as dressing and washing. Right side damage can also cause difficulty in making things (constructional apraxia), denial of deficits (anosognosia) and drawing ability. [21] Neglect syndrome tends to be more prevalent on the right side of the parietal lobe, because the right mediates attention to both the left and right fields. [21] Damage in the somatic sensory cortex results in loss of perception of bodily sensations, namely sense of touch.

Occipital lobe

The occipital lobe is the smallest of all four lobes in the human cerebral cortex and located in the rearmost part of the skull and considered to be part of the forebrain. [22] The occipital lobe sits directly above the cerebellum and is situated posterior to the Parieto-occipital sulcus, or parieto-occipital sulcus. [22] This lobe is known as the centre of the visual perception system, the main function of the occipital lobe is that of vision.

Retinal sensors send signals through the optic tract to the Lateral geniculate nucleus. Once the Lateral Geniculate Nucleus receives the information it is sent down the primary visual cortex where it is organized and sent down one of two possible path ways; dorsal or ventral stream. [23] The ventral stream is responsible for object representation and recognition and is also commonly known as the "what" stream. The dorsal stream is responsible for guiding our actions and recognizing where objects are in space, commonly known as the "where" or "how" stream. Once in the information is organized and sent through the pathways it continues to the other areas of the brain responsible for visual processing. [23]

The most important function of the Occipital lobe is vision. Due to the positioning of this lobe at the back of the head it is not susceptible to much injury but any significant damage to the brain can cause a variety of damage to our visual perception system. Common problems in the occipital lobe are field defects and scotomas, movement and colour discrimination, hallucinations, illusions, inability to recognize words and inability to recognize movement. [19] A study was done in which patients suffered from a tumour on the occipital lobe and the results shows that the most frequent consequence was contralateral damage to the visual field. When damage occurs in the occipital lobe it is most common to see the effects on the opposite side of the brain. Since the brain regions are so specialized in their functioning, damages done to specific areas of the brain can cause specific type of damage. Damage to the left side of the brain can lead to language discrepancies, i.e. difficulty in properly identifying letters, numbers and words, inability to incorporate visual stimuli to comprehend multiple ways an object can be found. [19] Right side damage causes non-verbal problems, i.e. identifying geometric shapes, perception of figures and faces. [19] In almost all regions of the brain left side damage leads to general language problems whereas right side damage leads to general perception and problem solving skills.

Damage to the cortex

Many studies of different disease and disorders that have symptoms of memory loss have provided reinforcing evidence to the study of the anatomy of the brain and which parts are more utilized in memory.

Frontotemporal lobar degeneration and memory

Frontotemporal lobar degeneration (FTLD) is a common form of dementia due to the degeneration of the frontal and temporal lobes. Studies have found significant decreases in the essential needs for proper functioning in these lobes. The autobiographical domain in memory is largely affected by this disease. In one study, FTLD patients were interviewed and asked to describe a significant event from five different periods of their lives. Using the interview and different methods of imaging, the experimenters hoped to find links between patterns of brain volume loss and performance in the interview. [24]

Through image processing, patterns of significant reduced parenchymal volumes that encompass the frontal and temporal lobes were found. Through comparison to a control group of patients it was found that parenchymal volumes increased during episodic recall, and decreased during semantic recall. The experimenters discussed that lifespan autobiographical episodic recall was largely damaged in FTLD patients and semantic autobiographical memory seemed to be spared. [24]

Parkinson's disease and memory

Parkinson's disease involves both damage to the basal ganglia and certain memory dysfunctions, suggesting that the basal ganglia are involved in specific types of memory. Those who have this disease have problems with both their working memory and spatial memory. [25]

Most people can instantly and easily use visual-spatial memory to remember locations and pictures, but a person with Parkinson's disease would find this difficult. He or she would also have trouble encoding this visual and spatial information into long-term memory. [25] This suggests that the basal ganglia work in both encoding and recalling spatial information.

People with Parkinson's disease display working memory impairment during sequence tasks and tasks involving events in time. They also have difficulty in knowing how to use their memory, such as when to change strategies or maintain a train of thought. [25]

Related Research Articles

<span class="mw-page-title-main">Visual cortex</span> Region of the brain that processes visual information

The visual cortex of the brain is the area of the cerebral cortex that processes visual information. It is located in the occipital lobe. Sensory input originating from the eyes travels through the lateral geniculate nucleus in the thalamus and then reaches the visual cortex. The area of the visual cortex that receives the sensory input from the lateral geniculate nucleus is the primary visual cortex, also known as visual area 1 (V1), Brodmann area 17, or the striate cortex. The extrastriate areas consist of visual areas 2, 3, 4, and 5.

<span class="mw-page-title-main">Cerebral cortex</span> Outer layer of the cerebrum of the mammalian brain

The cerebral cortex, also known as the cerebral mantle, is the outer layer of neural tissue of the cerebrum of the brain in humans and other mammals. The cerebral cortex mostly consists of the six-layered neocortex, with just 10% consisting of the allocortex. It is separated into two cortices, by the longitudinal fissure that divides the cerebrum into the left and right cerebral hemispheres. The two hemispheres are joined beneath the cortex by the corpus callosum. The cerebral cortex is the largest site of neural integration in the central nervous system. It plays a key role in attention, perception, awareness, thought, memory, language, and consciousness. The cerebral cortex is part of the brain responsible for cognition.

<span class="mw-page-title-main">Limbic system</span> Set of brain structures involved in emotion and motivation

The limbic system, also known as the paleomammalian cortex, is a set of brain structures located on both sides of the thalamus, immediately beneath the medial temporal lobe of the cerebrum primarily in the forebrain.

<span class="mw-page-title-main">Parietal lobe</span> Part of the brain responsible for sensory input and some language processing

The parietal lobe is one of the four major lobes of the cerebral cortex in the brain of mammals. The parietal lobe is positioned above the temporal lobe and behind the frontal lobe and central sulcus.

<span class="mw-page-title-main">Temporal lobe</span> One of the four lobes of the mammalian brain

The temporal lobe is one of the four major lobes of the cerebral cortex in the brain of mammals. The temporal lobe is located beneath the lateral fissure on both cerebral hemispheres of the mammalian brain.

<span class="mw-page-title-main">Occipital lobe</span> Part of the brain at the back of the head

The occipital lobe is one of the four major lobes of the cerebral cortex in the brain of mammals. The name derives from its position at the back of the head, from the Latin ob, 'behind', and caput, 'head'.

<span class="mw-page-title-main">Cerebrum</span> Large part of the brain containing the cerebral cortex

The cerebrum, telencephalon or endbrain is the largest part of the brain containing the cerebral cortex, as well as several subcortical structures, including the hippocampus, basal ganglia, and olfactory bulb. In the human brain, the cerebrum is the uppermost region of the central nervous system. The cerebrum develops prenatally from the forebrain (prosencephalon). In mammals, the dorsal telencephalon, or pallium, develops into the cerebral cortex, and the ventral telencephalon, or subpallium, becomes the basal ganglia. The cerebrum is also divided into approximately symmetric left and right cerebral hemispheres.

<span class="mw-page-title-main">Human brain</span> Central organ of the human nervous system

The human brain is the central organ of the human nervous system, and with the spinal cord makes up the central nervous system. The brain consists of the cerebrum, the brainstem and the cerebellum. It controls most of the activities of the body, processing, integrating, and coordinating the information it receives from the sense organs, and making decisions as to the instructions sent to the rest of the body. The brain is contained in, and protected by, the skull bones of the head.

<span class="mw-page-title-main">Visual memory</span> Ability to process visual and spatial information

Visual memory describes the relationship between perceptual processing and the encoding, storage and retrieval of the resulting neural representations. Visual memory occurs over a broad time range spanning from eye movements to years in order to visually navigate to a previously visited location. Visual memory is a form of memory which preserves some characteristics of our senses pertaining to visual experience. We are able to place in memory visual information which resembles objects, places, animals or people in a mental image. The experience of visual memory is also referred to as the mind's eye through which we can retrieve from our memory a mental image of original objects, places, animals or people. Visual memory is one of several cognitive systems, which are all interconnected parts that combine to form the human memory. Types of palinopsia, the persistence or recurrence of a visual image after the stimulus has been removed, is a dysfunction of visual memory.

Explicit memory is one of the two main types of long-term human memory, the other of which is implicit memory. Explicit memory is the conscious, intentional recollection of factual information, previous experiences, and concepts. This type of memory is dependent upon three processes: acquisition, consolidation, and retrieval.

<span class="mw-page-title-main">Papez circuit</span> Neural circuit

The Papez circuit, or medial limbic circuit, is a neural circuit for the control of emotional expression. In 1937, James Papez proposed that the circuit connecting the hypothalamus to the limbic lobe was the basis for emotional experiences. Paul D. MacLean reconceptualized Papez's proposal and coined the term limbic system. MacLean redefined the circuit as the "visceral brain" which consisted of the limbic lobe and its major connections in the forebrain – hypothalamus, amygdala, and septum. Over time, the concept of a forebrain circuit for the control of emotional expression has been modified to include the prefrontal cortex.

<span class="mw-page-title-main">Lobes of the brain</span> Parts of the cerebrum

The lobes of the brain are the major identifiable zones of the human cerebral cortex, and they comprise the surface of each hemisphere of the cerebrum. The two hemispheres are roughly symmetrical in structure, and are connected by the corpus callosum. They traditionally have been divided into four lobes, but are today considered as having six lobes each. The lobes are large areas that are anatomically distinguishable, and are also functionally distinct to some degree. Each lobe of the brain has numerous ridges, or gyri, and furrows, the sulci that constitute further subzones of the cortex. The expression "lobes of the brain" usually refers only to those of the cerebrum, not to the distinct areas of the cerebellum.

The two-streams hypothesis is a model of the neural processing of vision as well as hearing. The hypothesis, given its initial characterisation in a paper by David Milner and Melvyn A. Goodale in 1992, argues that humans possess two distinct visual systems. Recently there seems to be evidence of two distinct auditory systems as well. As visual information exits the occipital lobe, and as sound leaves the phonological network, it follows two main pathways, or "streams". The ventral stream leads to the temporal lobe, which is involved with object and visual identification and recognition. The dorsal stream leads to the parietal lobe, which is involved with processing the object's spatial location relative to the viewer and with speech repetition.

<span class="mw-page-title-main">Inferior temporal gyrus</span> One of three gyri of the temporal lobe of the brain

The inferior temporal gyrus is one of three gyri of the temporal lobe and is located below the middle temporal gyrus, connected behind with the inferior occipital gyrus; it also extends around the infero-lateral border on to the inferior surface of the temporal lobe, where it is limited by the inferior sulcus. This region is one of the higher levels of the ventral stream of visual processing, associated with the representation of objects, places, faces, and colors. It may also be involved in face perception, and in the recognition of numbers and words.

The perirhinal cortex is a cortical region in the medial temporal lobe that is made up of Brodmann areas 35 and 36. It receives highly processed sensory information from all sensory regions, and is generally accepted to be an important region for memory. It is bordered caudally by postrhinal cortex or parahippocampal cortex and ventrally and medially by entorhinal cortex.

<span class="mw-page-title-main">Superior longitudinal fasciculus</span> Association fiber tract of the brain

The superior longitudinal fasciculus (SLF) is an association tract in the brain that is composed of three separate components. It is present in both hemispheres and can be found lateral to the centrum semiovale and connects the frontal, occipital, parietal, and temporal lobes. This bundle of tracts (fasciculus) passes from the frontal lobe through the operculum to the posterior end of the lateral sulcus where they either radiate to and synapse on neurons in the occipital lobe, or turn downward and forward around the putamen and then radiate to and synapse on neurons in anterior portions of the temporal lobe.

Recognition memory, a subcategory of explicit memory, is the ability to recognize previously encountered events, objects, or people. When the previously experienced event is reexperienced, this environmental content is matched to stored memory representations, eliciting matching signals. As first established by psychology experiments in the 1970s, recognition memory for pictures is quite remarkable: humans can remember thousands of images at high accuracy after seeing each only once and only for a few seconds.

The neuroscience of music is the scientific study of brain-based mechanisms involved in the cognitive processes underlying music. These behaviours include music listening, performing, composing, reading, writing, and ancillary activities. It also is increasingly concerned with the brain basis for musical aesthetics and musical emotion. Scientists working in this field may have training in cognitive neuroscience, neurology, neuroanatomy, psychology, music theory, computer science, and other relevant fields.

<span class="mw-page-title-main">Neuroscience of sex differences</span> Characteristics of the brain that differentiate the male brain and the female brain

The neuroscience of sex differences is the study of characteristics that separate the male and female brains. Psychological sex differences are thought by some to reflect the interaction of genes, hormones, and social learning on brain development throughout the lifespan.

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