Ninein is a protein that in humans is encoded by the NIN gene. [5] [6] [7]
Ninein is a protein that in humans is encoded by the NIN gene. [5] [6] [7]
Ninein, together with its paralog Ninein-like protein is one of the proteins important for centrosomal function. Localization of this protein to the centrosome requires three leucine zippers in the central coiled-coil domain. Multiple alternatively spliced transcript variants that encode different isoforms have been reported. [7]
This protein is important for positioning and anchoring the microtubules minus-ends in epithelial cells. [7]
Pericentriolar material 1, also known as PCM1, is a protein which in humans is encoded by the PCM1 gene.
Centrosomal protein of 290 kDa is a protein that in humans is encoded by the CEP290 gene. CEP290 is located on the Q arm of chromosome 12.
Sperm-associated antigen 5 is a protein that in humans is encoded by the SPAG5 gene.
PAS domain-containing serine/threonine-protein kinase is an enzyme that in humans is encoded by the PASK gene.
Pericentrin (kendrin), also known as PCNT and pericentrin-B (PCNTB), is a protein which in humans is encoded by the PCNT gene on chromosome 21. This protein localizes to the centrosome and recruits proteins to the pericentriolar matrix (PCM) to ensure proper centrosome and mitotic spindle formation, and thus, uninterrupted cell cycle progression. This gene is implicated in many diseases and disorders, including congenital disorders such as microcephalic osteodysplastic primordial dwarfism type II (MOPDII) and Seckel syndrome.
Transforming acidic coiled-coil-containing protein 2 is a protein that in humans is encoded by the TACC2 gene.
Centrosome-associated protein 350 is a protein that in humans is encoded by the CEP350 gene.
Centriolin is a protein that in humans is encoded by the CNTRL gene. It was previously known as CEP110.
Tubulin gamma-2 chain is a protein that in humans is encoded by the TUBG2 gene.
Centrosomal protein of 68 kDa is a protein that in humans is encoded by the CEP68 gene. CEP68 is required for centrosome cohesion. It decorates fibres emanating from the proximal ends of centrioles. During mitosis, CEP68 dissociates from centrosomes. CEP68 and rootletin depend both on each other for centriole association, and both also require CEP250 for their function.
Tyrosine-protein phosphatase non-receptor type 23 is an enzyme that in humans is encoded by the PTPN23 gene.
Centrin-1 is a protein that in humans is encoded by the CETN1 gene. It belongs to the centrin family of proteins.
Ninein-like protein is a protein that in humans is encoded by the NINL gene. It is part of the centrosome.
Centrosomal protein of 72 kDa is a protein that in humans is encoded by the CEP72 gene.
Centrosomal protein of 70 kDa is a protein that in humans is encoded by the CEP70 gene. The protein interacts with γ-tubulin through its coiled coil domains to localize at the centrosome. CEP70 is involved in organizing microtubules in interphase cells and is required for proper organization and orientation of the mitotic spindle.
Centrosomal protein of 135 kDa is a protein that in humans is encoded by the CEP135 gene. It is part of the centrosome throughout the cell cycle, being distributed in the pericentriolar material. CEP135 is required for the centriolar localization of CEP250.
Centrosomal protein of 192 kDa, also known as Cep192, is a protein that in humans is encoded by the CEP192 gene. It is the homolog of the C. elegans and D. melanogaster gene SPD-2.
Centrosomal protein of 164 kDa, also known as CEP164, is a protein that in humans is encoded by the CEP164 gene. Its function appears two be twofold: CEP164 is required for primary cilium formation. Furthermore, it is an important component in the response to DNA damage by UV light.
Centrosomal protein of 76 kDa, also known as CEP76, is a protein that in humans is encoded by the CEP76 gene.
Centrosomal protein of 152 kDa, also known as Cep152, is a protein that in humans is encoded by the CEP152 gene. It is the ortholog of the Drosophila melanogaster gene asterless (asl) and both are required for centriole duplication.
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